Keywords

• C-Phycocyanin
• C-PHYCOCYANIN PARTIALLY PURIFIED FROM*SP IRULINA SP.
• C-phycocyanin partially purified from*spirulina S

Quick Details

• ProName: C-PHYCOCYANIN 11016-15-2
• CasNo: 11016-15-2
• Appearance: Blue
• Application: For the combination experiments, when ...
• DeliveryTime: 7-10 working days
• PackAge: In plastic outside weave or according ...
• Port: port of Qingdao、port of Tianjin
• ProductionCapacity: 500 Kilogram/Week
• Purity: >99%
• Storage: -15°C
• Transportation: We ship goods via DHL, Fedex, UPS, TNT...
• LimitNum: 1 Kilogram
• Shelf Life: Two years

Superiority

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Uses and synthesis methods

natural nutrients

Phycocyanin is a blue pigment extracted from Spirulina and is a pure natural food pigment. Phycocyanin is one of the rare pigment proteins in nature. It is not only brightly colored, but also a nutritious protein and a good health food. It is the only natural blue pigment approved by FDA in the United States. The European Union has listed phycocyanin as a raw material for colored food, and its use in food is not restricted. China GB2760 Food Additives Catalogue also allows phycocyanin to be used as a natural colorant. Phycocyanin can also be used as medical and health products, cosmetics raw materials, biochemical reagents, etc.

application

The application research of phycocyanin is very common, and the following aspects can be summarized:

(1) natural food pigment: phycocyanin is a water-soluble pigment, pure blue, clear and lovely, and can be used as an additive for food colorants and cosmetics. And it is very rich in protein.

(2) medicine and health food: phycocyanin in vitro experiments proved that it has the effect of stimulating erythrocyte colony formation, similar to erythropoietin (EPO). Phycocyanin can help regulate and synthesize a variety of important enzymes needed by the human body. It plays an important role in inhibiting the growth of cancer cells. It can also regulate the human body's immune system, enhance the function of the immune system, and improve the body's resistance to diseases.

(3) cosmetics field: phycocyanin is a kind of collagen, with antioxidant, moisturizing, anti-allergic, freckle and other effects.

(4) special reagents for biology, chemistry and cytology experiments: phycocyanin blue and fluorescent, which can be used as some photodynamic research reagents for biology and cytology. It can also be used as a biochemical marker.

Isolation and purification of phycocyanin

freeze-thaw method: freeze the cells at low temperature for a certain period of time, then take them out and melt them at room temperature. Such repeated freezing and thawing for many times can cause swelling and fragmentation of cells while forming ice particles and increasing the concentration of remaining cytosolic salts.

Salting-out method: The positive and negative ions formed by the ionization of salt in the aqueous solution can attract water molecules, thereby destroying the water film of the protein, neutralizing part of the charge, causing the protein to aggregate and precipitate and precipitate from the solution. Due to the difference in the size of various protein particles, the amount of charge and the degree of hydrophilicity, when a certain neutral salt is used for salting out, the minimum salt concentration required is different.

DEAE cellulose: English name DEAE-Cellulose, diethylamine ethyl cellulose, total exchange capacity 0.9meq/g functional group: diethylamine ethyl weakly basic anion exchanger. Principle: Contains certain functional groups, which can be ion exchanged. The performance is milder than that of general ion exchange resins, which is suitable for separating macromolecules with biological activity, and can separate macromolecular substances with similar properties.

Food grade phycocyanin

Phycocyanin is an active protein isolated and purified from cyanobacteria. It is a rare scarp pigment protein. It is a natural edible pigment allowed by the country. More importantly, studies have shown that phycocyanin can significantly reduce tumor radiation The damage to normal white blood cells in the human body during chemotherapy stimulates the colony of red blood cells and platelets, improves immunity, and protects liver tissue. It has unique fluorescence properties and good biological efficacy. It has the same properties as protein. The product is blue particles or powder. Soluble in water. Insoluble in alcohol and grease. Organic solvents such as ethanol can cause irreversible denaturation of phycocyanin. The color of its aqueous solution is bright blue. Each phycocyanin monomer consists of a subunit and B subunit. its monomer (AB) has a molecular weight of about 40,000 d, a trisomal (AB) at pH6.5-8.0, and a hexasomal (AB) at pH4.5-6.0, with a molecular weight of about 230,000 d. No matter in the form of monomer, three-body or six-body, it presents a beautiful sapphire color under visible light, and its color is bright. It is quite stable under various physical and chemical factors.

Uses and synthesis methods

In vitro studies

For the combination experiments, when cells treated with All-trans retinoic acid (ATRA) combined with C- phycocyanin, the IC 50 value is lower than that in ATRA group. But under the same IC 50 , the more C- phycocyanin is used, the less ATRA is needed. Results demonstrate that C- phycocyanin combined with ATRA can significantly decrease CDK-4 mRNA level (P<0.05). The combination index (CI) value of the C- phycocyanin ATRA combination group is 0.852 which is less than 1, indicating that the two drugs are synergetic under the action concentration (88 μg/L C- phycocyanin 0.102 mM ATRA). Compare with control group, the Integrated optical density (IOD) in C- phycocyanin or ATRA treated group is increased, and the differences are statistically significant (P<0.05) and the differences are further exaggerated in combination group (P<0.01). The expression of caspase-3 in C- phycocyanin group is more than that in the control group but is similar to that in ATRA group, whereas the expression in combination group is maximum.

In vivo studies

Compare with control group, the average tumor weights of mice in solely C- phycocyanin or ATRA treatment groups are significantly decreased, and further reduced in C- phycocyanin ATRA synergy group. Results show that single C- phycocyanin can increase the spleen weight of mice but the effects of ATRA are just opposite. C- phycocyanin can also promote the growth of immune organs in mice and increase the body's immune function. C- phycocyanin and ATRA alone can significantly inhibit Cyclin D1 expression, and when being combined, the inhibitory effect is more obvious.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.