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Hebei Nengqian Chemical Import and Export Co., LTD

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Hebei Nengqian Chemical Import and Export Co., LTD

Country: China (Mainland)

Business Type:Trading Company

Ms.Winnie

Tel: +86 18233902561

Mobile: +86 18233902561

Tel: +86 18233902561

Fax: 4001020630

URL: https://www.nengqianchemical.com/

Province/state: Hebei

City: Handan

Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province

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AZD5363

CAS NO.1143532-39-1

  • FOB Price: USD: 30.00-80.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
  • Available Specifications:

    medical grade(1-50)Kilogrammedical grade(50-500)Kilogram

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Product Details

Keywords

  • CAPIVASERTIB
  • (S)-4-Amino-N-(1-(4-chlorophenyl)
  • 3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide

Quick Details

  • ProName: AZD5363 1143532-39-1
  • CasNo: 1143532-39-1
  • Molecular Formula: C21H25ClN6O2
  • Appearance: solid
  • Application: Used in pharmaceutical intermediates
  • DeliveryTime: 5-7 woking day
  • PackAge: 1 kg/bag; 25 kg/carton
  • Port: Qingdao port, Tianjin port
  • ProductionCapacity: 3000 Kilogram/Month
  • Purity: >99%
  • Storage: Room Temprature
  • Transportation: according to your needs
  • LimitNum: 1 Kilogram
  • packing: According to your request

Superiority

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details

Molecular Formula C21H25ClN6O2
Molar Mass 428.92
Density 1.381
Melting Point 161-164°C
Solubility DMSO (Slightly), Methanol (Slightly)
Appearance Solid
Color Off-White to Pale Beige
pKa 13.93±0.50(Predicted)
Storage Condition Refrigerator
In vitro study AZD5363 is a potent inhibitor of Akt, inhibiting Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. The activation of PIK3CA mutation, the loss or inactivation of the tumor suppressor gene PTEN, or the amplification of HER2 all have a significant relationship with AZD5363. Furthermore, a correlation between the RAS mutational status of the cell lines and the anti-azd5363 can also be seen. AZD5363 inhibited phosphorylation of AKT substrates in cells with a titer of about 0.3~0.8 μm. AZD5363 inhibited cell proliferation in 41 of 182 solid and hematologic tumor cell lines with a titer of <3 μm.
In vivo study AZD5363 was orally administered to nude mice at a dose of 100,300 mg/kg to reduce the phosphorylation of PRAS40, GSK3β, and S6 in the transplanted tumor of BT474c in a dose-and time-dependent manner, it also reversibly increases blood glucose concentration and reduces 2 [

 

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