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CAS NO.218949-48-5
Medical level(1-50)KilogramMedical level(50-500)Metric Ton
High Purity 218949-48-5 Tesamorelin White powder
Tymorlin consists of 44 amino acid sequences of human growth hormone release factor (GRF), attached to 3-hexylylyl on its tyrosine N-end residue, molecular formula is C221H366N72O67S.xC2H4O (x≈7), and relative molecular mass (free alkali) is 5135.9. For the new growth hormone release factor analogues, not only can make the body's growth hormone secretion return to normal, but also can make the increased visceral adipose tissue (VAT) reduced, and can improve blood lipid abnormalities and quality of life, maintain the dynamic balance of glucose in the body. The drug was approved by the FDA in November 2010 for the treatment of HIV-related fat metabolic disorder syndrome.
After 2mg of subcutaneous injections of merrin in healthy adults, absolute bioavailance was less than 4%. Healthy people without fat metabolic disorders and HIV-infected patients were injected with a single dose of 2 mg under the skin, the sub-curve area (AUC) was 634.6±72.4) and (852.8±91.9) pghmL-1, respectively, and the concentration of blood peak (cmax) was 2874.6±43.9) and (2874.6±43.9, respectively 2822.3±48.9) pgmL-1, peaking at 1.5h, apparent distribution volume (9.4±3.1) and (10.5±6.1) Lkg-1, respectively, after the continuous application of 14d after the average elimination of half-life (t1/2) is 26 and 38min, respectively.
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