Details
Our advantage:
1. High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Melting Point |
49-51°C |
| Boling Point |
715.32°C (rough estimate) |
| Flash Point |
324.5°C |
| Solubility |
Soluble in chloroform, benzene, carbon tetrachloride, soluble in acetone, ether, slightly soluble in ethanol, insoluble in water, methanol. |
| Vapor Presure |
1.23E-30mmHg at 25°C |
| Appearance |
Yellow crystalline powder |
| Color |
Light Orange to Dark Orange |
| Merck |
14,9843 |
| BRN |
1900141 |
| Storage Condition |
-20°C |
| Stability |
Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents. |
| Sensitive |
Light Sensitive |
| Refractive Index |
1.4760 (estimate) |
| MDL |
MFCD00042919 |
| Physical and Chemical Properties |
Properties: yellow or orange-yellow crystalline powder; Odorless and tasteless; Easy to decompose in light
melting point 48-52°C
|
| Use |
Can be widely used in food, cosmetics, dietary supplements and other industries. |
Nature
Open Data Verified Data
- This strain was prepared by extracting from porcine heart residue after extraction of cytochrome C. Yellow or light orange crystalline powder, odorless and tasteless, melting point of 47~52 ℃, soluble in chloroform, benzene, acetone, petroleum ether, ether, ethanol-soluble, insoluble in water and methanol. Easy to decompose in light, so that the color darkened. In the presence of a reducing agent, it can be converted into colorless reduced coenzyme Q10, which in turn can be oxidized into oxidized coenzyme Q10. The ethanol solution of oxidized Coenzyme Q10 has a maximum absorption at 275nm and a broadband absorption at 405nm. The absorption peaks of reduced coenzyme Q10 disappeared at 275nm and 405nm, and the maximum absorption appeared at 290nm.
- Coenzyme Q10 is a proton translocator and electron transporter in the respiratory chain of biological cells. Chemically, it is a group of fat-soluble quinone compounds, different sources of coenzyme Q, its side chain isopentene unit number is different, human and mammal is 10 isopentene unit. This product is a metabolic activator, can activate cell respiration, accelerate the production of adenosine triphosphate (ATP). It is a natural antioxidant produced by the cell itself, which can inhibit the peroxidation of mitochondria and protect the structural integrity of the biofilm. It has non-specific enhancing effect on immunity, can increase the phagocytic rate of phagocytes, increase the production of antibodies and improve the function of T cells.
Nature
Open Data Verified Data
- This strain was prepared by extracting from porcine heart residue after extraction of cytochrome C. Yellow or light orange crystalline powder, odorless and tasteless, melting point of 47~52 ℃, soluble in chloroform, benzene, acetone, petroleum ether, ether, ethanol-soluble, insoluble in water and methanol. Easy to decompose in light, so that the color darkened. In the presence of a reducing agent, it can be converted into colorless reduced coenzyme Q10, which in turn can be oxidized into oxidized coenzyme Q10. The ethanol solution of oxidized Coenzyme Q10 has a maximum absorption at 275nm and a broadband absorption at 405nm. The absorption peaks of reduced coenzyme Q10 disappeared at 275nm and 405nm, and the maximum absorption appeared at 290nm.
- Coenzyme Q10 is a proton translocator and electron transporter in the respiratory chain of biological cells. Chemically, it is a group of fat-soluble quinone compounds, different sources of coenzyme Q, its side chain isopentene unit number is different, human and mammal is 10 isopentene unit. This product is a metabolic activator, can activate cell respiration, accelerate the production of adenosine triphosphate (ATP). It is a natural antioxidant produced by the cell itself, which can inhibit the peroxidation of mitochondria and protect the structural integrity of the biofilm. It has non-specific enhancing effect on immunity, can increase the phagocytic rate of phagocytes, increase the production of antibodies and improve the function of T cells.
Production method
Open Data Unverified Data
Semi-synthesis
The semi-synthetic process developed at present is to obtain Coenzyme Q10 by bromination, etherification and oxidation of p-methylphenol as raw material to obtain methyl dimethoxy benzene, and then condensation with solanesol extracted from tobacco or potato leaves. The key to this approach is how to attach the side chain to the parent ring.
total synthesis
The total synthesis process developed by Eem and Kanan in 1988 to produce Coenzyme Q10 is the only successful total synthesis technology at present, but it is difficult to synthesize the linear unsaturated side chain. And the synthesis conditions are harsh, and there is a certain distance from industrialization.
fermentation method
The production of coenzyme Q1o by microbial fermentation was realized in 197. This production process is considered to be the most promising synthesis process. In recent years, microbial fermentation has become a hot spot of development at home and abroad. The main strains for producing Coenzyme Q10 were tricylobacter rugosa, tricylobacter denitrificans, and methanogens.
plant cell culture method
The Plant Cell culture technique is a technique in which a part of a plant body is aseptically treated, and then placed on an artificial medium to proliferate its cells, and then cultured as needed. All parts of the plant, such as roots, stems, leaves, flowers, fruits, anthers and pollen, can be used as explants to start cell culture, the transfer of callus to a liquid medium for culture is called suspension culture.
Biological extraction method
- Alcohol-alkali saponification production method the yield of coenzyme Q10 in this process is 61.2mg kg fresh pig heart, which is a commonly used process in China. In the presence of ethanol, long-term saponification may result in transposition of methoxy groups in Coenzyme Q10 and ethoxy groups in ethanol to produce mono-or BIS-ethoxy derivatives, in order to avoid the formation of these impurities. KOH can be used instead of NaOH and methanol saponification, but also must be added pyroic acid, otherwise Coenzyme Q10 in the saponification process is completely destroyed, the amount of 5%-7% of the starting material, nitrogen can be introduced into the saponification process.
- Alcohol-ether mixed extraction method, the process of alcohol-alkali saponification manufacturing process is similar, but the saponification reaction is omitted. Biological extraction is the world's oldest basic production process, for some time was the only method of production of Coenzyme Q10. However, due to the low content of coenzyme Q10 in animals and plants, the complex chemical composition and the limited source of raw materials (mainly extracted from fresh liver of animals), the products are of high cost and high price, large-scale production has been limited.
Functional use
Anti-Aging
- Coenzyme Q10 has two main functions in the body. One is that it plays an important role in the process of energy conversion in mitochondria, and the other is that it has obvious anti-lipid peroxidation effect. It is an energy converter in the mitochondria of cells that participates in the "tricarboxylic acid cycle" by transferring and transmitting electrons to produce ATP (adenosine triphosphate), an energy factor for cellular metabolism. At the age of 20, the ability of self-synthesized Coenzyme Q10 reached its peak, and maintained to about 50 years old. Later will decline year by year, because the storage of coenzyme Q10 cell mitochondrial DNA material is destroyed by oxygen free radicals, resulting in the reduction of self-synthesis of Coenzyme Q10. As a result, the metabolic function of human cells, especially heart cells, decreased, and the "old dragon clock" appeared.
- the experiment proves that coenzyme Q10 in vivo can directly react with peroxide radicals and regenerate vE by changing into alcohol form, and exert the effect of antioxidant independently and synergistically with vE. In vitro experiments also found that the antioxidant Coenzyme Q10 can protect mammalian cells from mitochondrial oxidative stress-induced apoptosis, and tumor necrosis factor-(TNF-) or oncogene inhibitors have no such effect, clinical studies have shown that oral Coenzyme Q10 for the treatment of Parkinson's disease, Huntington's disease and Alzheimer's disease and other mitochondrial dysfunction and aging related neurodegenerative diseases have a significant effect.
- the relationship between aging and mitochondrial coenzyme Q10 concentration shows that the decrease of mitochondrial coenzyme Q10 concentration is an important aspect of skeletal muscle aging. An experimental study of aging rats showed that the content of coenzyme Q10 in heart mitochondria of aging rats was decreased, and the content of coenzyme Q10 in liver and skeletal muscle was lower. The decline in immune function with age is the result of free radical and free radical reactions. Coenzyme Q10 is a potent antioxidant and free radical scavenger, which is embedded in the inner mitochondrial membrane lipid bimolecular as a component of the mitochondrial respiratory chain, the two electrons received from the mitochondrial complex I or complex II are then converted to alcohol, and the electrons are transferred to complex III. Coenzyme Q10 in the body is largely consumed into alcohol, which is both an effective antioxidant and an electron carrier for movement, and it converts hydrogen atoms from their hydroxyl groups to lipid peroxidation free radicals, the lipid peroxide response in the inner mitochondrial membrane is thus reduced. In this process, a free radical pansemiquinone, which is not proportional to the alcohol form of coenzyme Q10 and coenzyme Q10, or reacts with oxygen to form superoxide, free radical ubiquinone in the role of superoxide dismutase and catalase transport free radicals to achieve detoxification, so that the circulation of the respiratory chain will be Coenzyme Q10 continuously regenerated alcohol, restore its antioxidant activity.
- The decline in immune function with age is the result of free radicals and free radical reactions, coenzyme Q10 as a strong antioxidant used alone or with vitamin B6 (pyridoxine) the combined use can inhibit the modification of the microtubule system of the receptors on immune cells, which is related to cell differentiation and activity, enhance the immune system and delay aging.
- the increase of wrinkles and the aging of the skin are related to the content of Q10. The lower the content, the more the skin is aged, and the more the facial wrinkles are. Q10 can be taken orally, when the cells contain enough Q10 that the energy metabolism will be enhanced, scavenging free radicals, ease wrinkles aggravated.
- In addition, skin care products containing Coenzyme Q10 can also be rubbed, and the absorption of coenzyme Q10 by cells can be increased by improving external use, thereby reducing the formation of wrinkles.
Anti-Fatigue
- in the mid -70 s, the theory of Miller's chemical permeability hypothesis revealed the energy conversion in vivo and the important role of coenzyme Q10 in the mitochondrial energy conversion system.
- Coenzyme Q10 is a coenzyme of at least three mitochondrial enzymes (multienzyme complexes I, II and III), its chemical structure is a 2,3 dimethoxy 5 methyl 1,4 benzoquinone derivative with a ten unit isoprene side chain attached to the carbon at position 6.
- its quinone ring plays a role in the transfer of electrons and protons in the oxidative respiratory chain. This role is not only essential for all forms of life, but also the key to the formation of ATP. ATP is the main form of storage of the body's energy, but also an important basis for the normal functioning of all cells, Coenzyme Q102.2 detection wavelength: the biological activity of 275nm mainly comes from the redox characteristics of its quinone ring and the physical and chemical properties of its side chain. It is a natural antioxidant and cell metabolism promoter produced by the cell itself, which can protect and restore the integrity of the biofilm structure and stabilize the membrane potential. It is a non-specific immune enhancer of the body, therefore, it shows an excellent anti-fatigue effect. Coenzyme Q10 keeps the cells in a good and healthy state, so the body is full of vitality, energy and energy.
Antioxidant
- the etiology and pathology of chronic fatigue syndrome (CFS) are still unclear, and studies have shown that oxidative stress is a cause of the disease, experiments found that CFS patients have different degrees of oxidative stress, although the oxidative damage is the cause of the disease or the results need to be further observed, but the antioxidant Coenzyme Q10 has been successfully used in the prevention and treatment of chronic fatigue syndrome.
- In addition, the antioxidant activity of coenzyme Q10 makes it have a certain inhibitory effect on the formation and development of atherosclerosis. And its oxidation resistance makes the membrane stable, metabolic cardiac and reverse left ventricular hypertrophy and other good effects, in cardiovascular disease is increasingly widely used.
Anti-Tumor
research shows that coenzyme Q10 has anti-tumor effect, clinical for advanced metastatic cancer has certain curative effect, in the prevention of coronary heart disease, relieve periodontitis, the treatment of duodenal ulcer and gastric ulcer, enhance Human immune function and relieve angina pectoris has a significant effect.
Security
Since coenzyme Q10 is an OTC product on the US and European markets, and several well-designed clinical trials have shown that oral Coenzyme Q10 is beneficial for a variety of cardiovascular diseases, therefore, based on its efficacy and safe and reliable characteristics, even for a long time, oral administration of large doses of coenzyme Q10, patients can be well tolerated.
Antihypertensive
significant research conducted by the Argentina Institute of Neuroscience has shown that oral administration of 100mg of coenzyme Q10 within an hour in patients with high blood pressure can enhance brain treatment and agility.
Skin protection
- Local experiments show that with the increase of age, the ability of skin collagen to resist the damage of ultraviolet and other oxidative irritants decreases, and long-term use of coenzyme Q10 can effectively prevent skin aging and reduce wrinkles around the eyes, because the penetration of coenzyme Q10 into the skin growth layer can weaken the oxidation reaction of photons, with the help of tocopherol can start specific phosphorylated tyrosine kinase, prevent DNA oxidative damage, inhibit the expression of human skin fibroblast collagenase under ultraviolet light irradiation, protect the skin from damage. Extensive studies have shown that coenzyme Q10 inhibits lipid peroxidation, reduces the generation of free radicals, protects the active center of SOD and its structure from free radical oxidative damage, and improves the activity of SOD and other enzymes in vivo, inhibition of oxidative stress induced apoptosis, has a significant role in anti-oxidation, anti-aging.
- can deepen the cells, strengthen the metabolic function of the cells, and the ability of the active cells to tightly combine with each other. On the other hand, in the epidermal layer, the elastic network structure of the gel is indeed repaired due to the loss of water, and then achieve a real moisturizing effect.
- Features: can repair the skin of the skin, such as thin skin or skin atrophy caused by the use of medicinal cosmetics, can be used for 3-6 months to improve.
- for the introduction can increase the absorption of active ingredients, and increase the resistance of cells, the effect is the most perfect, improve the skin water shortage problem is more thorough. Coenzyme Q10 antioxidant, can eliminate free radicals, maintain the integrity and stability of the cell membrane.
heart protection
coenzyme Q-10 helps to provide sufficient oxygen to the myocardium and prevent sudden heart attack. Coenzyme Q10 plays a key role in the process of myocardial hypoxia.
Adjunctive drugs
statins inhibit cholesterol synthesis and also inhibit the production of coenzyme Q10 in the body. Elderly patients are more likely to suffer from Coenzyme Q10 deficiency, in the use of statin drugs must be supplemented with coenzyme Q10. Rapid relief of statin-induced myalgia and fatigue counteracts statin-related myalgia and liver damage.
Enhanced energy
- experiments show that coenzyme Q10 can greatly promote heart health, and an appropriate amount of coenzyme Q10 in the human body is necessary for proper muscle function. Biochemical analysis of muscle cell extract showed that the activity of mitochondrial complex I + II and complex I + III was seriously decreased when the concentration of coenzyme Q10 was lower than normal 20%.
- Several studies have clearly shown that supplementation of coenzyme Q10 at 100-150mg/day can significantly improve the condition of people suffering from muscular dystrophy. Strenuous physical exercise reduces the blood content of coenzyme Q10, and a daily supplement of 60mg has been found to improve the skills of athletes. Many overweight people have a very low content of coenzyme Q10, and the supplement can make them lose weight, this is because the role of coenzyme Q10 can accelerate the metabolism of fat, so that the limbs and brain energy supply, he has high energy.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.
China (Mainland)
