Keywords

• a-Carotene,6',7'-didehydro-5,6-epoxy-4',5,5',6,7,8-hexahydro-3,3',5'-trihydroxy-8-oxo-,3'-acetate (7CI)
• Fucoxanthin DISCONTINUED;(3S,3'S,5R,5'R,6S,6'R)-
• ;Fucoxanthin DISCONTINUED;(3S,3'S,5R,5'R,6S,6'R)-

Quick Details

• ProName: Fucoxanthin 3351-86-8
• CasNo: 3351-86-8
• Molecular Formula: C42H58O6
• Appearance: White Crystalline Powder
• Application: Application 1. In addition to being us...
• DeliveryTime: 7-15 working days
• PackAge: Bag/compartments
• Port: tianjin
• ProductionCapacity: 200 Metric Ton/Month
• Purity: 99%
• Storage: Dry, away from light, sealed.
• Transportation: We will choose the mode of transportat...
• LimitNum: 1 Metric Ton
• color: White powder

Superiority

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.

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Our plant has strict quality control in each manufacturing process. Guaranteed.
Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.

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90% of orders are shipped within 7-10 days after receipt of the prepayment or workable L/C.

Respond in 24 hours to inquiry, feedback or other requirements
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Details

Product introduction:

Uses and methods of synthesis

Overview

fucoidan (fucoxanthin), also known as fucoidin, fucoidin, is a kind of natural pigment of lutein in carotenoids, it accounts for more than 700 of the total amount of about 10% naturally occurring carotenoids, and is light yellow to brown in color, which is contained in brown algae, diatoms, gold algae and yellow green algae. It is widely found in a variety of algae, marine phytoplankton, aquatic shellfish and other plants and animals. With anti-tumor, anti-inflammatory, anti-oxidation, weight loss, nerve cell protection, increasing the content of ARA (arachidonic acid) and DHA (two carbon hexaenoic acid) in mice and other pharmacological effects, as a drug, skin care and beauty products and health products are widely used in the market.

efficacy and function

fucoxanthin, a carotenoid found in brown seaweed, is being studied for its ability to burn fat. It reduces the amount of fat and does not stimulate the brain. Looks healthy, but more evidence is needed. It also has other health benefits, such as correcting glucose metabolism abnormalities in muscle tissue, which may help diabetics and may lower cholesterol levels and triglycerides by mechanisms that have not yet been validated. After supplementation with fucoidan, blood pressure decreased, liver fat storage and liver enzyme values decreased.

features

1. Absorption and metabolism

fucoidan and Amarouciaxanthin A are the major primary metabolites of fucoxanthin. The ingested fucoidan is hydrolyzed into fucoidan by digestive enzymes (such as lipase and cholesterol esterase) in the gastrointestinal tract, and then enters the systemic circulation through the lymph. Part of the Fucoidan is degraded into Amarouciaxanthin A in the liver, fucoidan and Amarou-ciaxanthin A were further metabolized by subsequent enzymatic reactions such as isomerization, dehydrogenation, deacetylation, oxidation and demethylation.

2. Safety

Fucoxanthin has no effect on liver, kidney, spleen and gonadal tissue, but can cause hypercholesterolemia. There was no teratogenicity of fucoidan in vitro, and there was no teratogenicity of fucoidan in vivo at 500, 1000 and 2000 mg/kg doses.

3. Stability

high-purity fucoxanthin is unstable to heat and easily oxidized. However, the fucoxanthin extract obtained from algae has stability due to the common presence of antioxidant substances (such as polyphenols and the like).

The pigment was sensitive to light and its stability was greatly improved when stored in the dark. At the same time, other antioxidants can protect the pigment from degradation. In addition, fucoxanthin is more stable than neutral and acidic under alkaline pH conditions, with the greatest stability at pH 9 and the least stable under acidic conditions.

fucoxanthin in algae is stable during dry processing and storage at room temperature.

extraction and separation methods

fucoxanthin is a natural carotenoid, which is insoluble in water and other highly polar solvents under neutral conditions, and soluble in non-polar organic solvents. It is a fat-soluble pigment. The extraction of pigment in dry powder is usually carried out by adding a small amount of small polar solvent into non-polar solvent.

1. The extraction process of Fucoxanthin from Laminaria japonica: Using anhydrous ethanol-acetone-petroleum ether (4:1:1) as the extraction solvent, 40 C extraction 2 times, each time 1H. After saponification, the extracted extract was separated and purified by silica gel column chromatography to obtain a high purity product with a purity of 91.6%.

2. Sargassum fusiforme in the extraction process: 90% ethanol-acetone (3:1) composite solvent as the extractant, in the ratio of liquid to material 40:1, ultrasonic temperature 65 ℃ water bath shaking extraction 2 times, the extraction rate was 1.067mg · g-1 for 80min each time.

3. Extraction process of Fucoxanthin from undaria pinnatifida: 3% methanol as entrainer, pressure 200dN/mm2, temperature 323K. Or ethanol as entrainer, using supercritical CO2 extraction from kelp root preparation of fucoxanthin, the purity of crude extract was 5%.

analysis detection

detection by spectrophotometry and high performance liquid chromatography

1. UV spectrophotometry: the absorption value of the sample is measured at 449nm, and the Theoretical absorption value of 1g · L-1 concentration of solute in the cuvette of 1cm optical path length is calculated as 1600, this method is relatively simple, but because other impurities are also absorbed at 449nm, the accuracy is poor.

2. High performance liquid chromatography: C18 column, acetonitrile-methanol-0.1% ammonium acetate solution (75:15:10) as mobile phase, at 450nm wavelength for determination, the method is more accurate, it is a feasible method with high sensitivity, but the detection methodology has not been systematically studied.

pharmacological effects

1. Anti-tumor effect

(1) skin cancer

fucoxanthin can inhibit the enhancement of ornithine decarboxylase activity in the epidermis of mice induced by the strong skin cancer-promoting substance decanoyl phorbol acetate (tetradecanoylphorbol-13-acetate,TPA), at the same time cocoa inhibits TPA-induced activation of human herpes Virus, thereby inhibiting TPA-induced skin tumors.

(2) colon cancer

Fucoxanthin has an inhibitory effect on N-ethyl-N'-nitro-N-nitrosoguanidine-induced duodenal carcinoma formation. Fucoxanthin significantly inhibited the growth of colon cancer cell lines, including Caco-2,HT-29 and DLD-1. It can induce DNA breakage of colon cancer cells, promote apoptosis, and inhibit the expression of apoptosis-related protein Bcl-2.

fucoxanthin inhibited the proliferation of human colon cancer cell line WiDr cells in a dose-dependent manner, blocked the cell cycle at G0/ G1 phase and induced apoptosis.

(3) blood system tumor

effect of fucoxanthin on acute myeloid leukemia HL-60 cell line. Fucoxanthin significantly inhibited the proliferation of HL-60 cells. Role of fucoxanthin in adult T-cell lymphoblastic leukemia. Fucoxanthin and its metabolite fucoxanthol inhibit the survival of human virus T-cell leukemia type 1 (human T-cell virus type 1,HTLV-1) infected T cells and adult T-cell leukemia cells.

(4) prostate cancer

fucoxanthin significantly decreased the survival rate of prostate cancer cells and induced apoptosis. Both fucoxanthin and its metabolite fucoxanol inhibited the proliferation of PC-3 cells and activated Caspase-3 to induce apoptosis.

(5) liver cancer

fucoxanthin inhibited the growth of human hepatoma HepG2 cells, blocked the cells in G0/G1 phase, and inhibited the phosphorylation of Rb protein at Ser780 site.

2. Antioxidant effect

Fucoxanthin has a good antioxidant effect, even better than vitamin E and vitamin C. Fucoxanthin has a protective effect on human fibroblast damage caused by UV-B. The antioxidant effect of fucoxanthin is mainly through the regulation of Na +-K +-ATPase activity, and the regulation of catalase and glutathione activity in tissues and molecules due to retinol deficiency.

3. Anti-inflammatory effect

fucoxanthin inhibited the exudation of inflammatory mediators induced by endotoxin in a dose-dependent manner, and its anti-inflammatory effect was equivalent to that of prednisolone, indicating that fucoxanthin had a significant effect on the inflammatory infiltration induced by endotoxin in mice, NO,PGE2 and tumor necrosis factor have a certain inhibitory effect. Its anti-inflammatory effect is mainly by inhibiting the exudation of NO in the inflammatory response caused by lipopolysaccharide-induced macrophages. RT-PCR analysis showed that the mRNA of NO synthase and cyclooxygenase was inhibited by fucoxanthin, tumor necrosis factor, leukocyte mediated IL-1β and IL-6, and mRNA survivin expression were inhibited by fucoxanthin in a dose-dependent manner, these results suggest that fucoxanthin may play an important role in a variety of inflammatory responses.

4. Weight loss

fucoxanthin can eliminate the accumulation of fat in two ways. Fucoxanthin activates a protein called UCP1, which promotes lipolysis. It also stimulates the liver to produce DHA, which lowers cholesterol levels.

5. Other

sea urchin dietary algae contain fucoxanthin and have significant effects on macrophage phagocytosis and ovulation.

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.