Hebei Nengqian Chemical Import and Export Co., LTD
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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Ms.AnnaCAS NO.373-49-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
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Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
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Dedicated to serving customers first, we provide reasonable prices, high quality products.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Molecular Formula | C16H30O2 |
| Molar Mass | 254.41 |
| Density | 0.895 g/mL at 20 °C (lit.) |
| Melting Point | 0.5 °C (lit.) |
| Boling Point | 162 °C/0.6 mmHg (lit.) |
| Flash Point | 62 °C |
| Solubility | Insoluble in water, soluble in alkali solution, soluble in ether, chloroform, ethyl acetate |
| Vapor Presure | 2.82E-06mmHg at 25°C |
| Appearance | Transparent colorless liquid |
| Color | Clear |
| BRN | 1725389 |
| pKa | 4.78±0.10(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Sensitive to air and heat |
| Refractive Index | 1.457-1.459 |
| MDL | MFCD00004437 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | palmitoleic acid is a ω-7 monounsaturated fatty acid composed of 16 carbon atoms and containing 1 double bond, which has important application value in nutrition, medicine and industry. Palmitoleic acid can reduce the level of C- reactive protein (CRP), reduce the risk of heart disease and stroke by reducing inflammation; increase the fluidity of cell membranes, reduce the content of low-density lipoprotein cholesterol (LDL) in the blood, and reduce atherosclerosis in blood vessels. Blocking blood vessels caused by the formation of plaque, thereby preventing arrhythmia and reducing high blood pressure. In addition, palmitoleic acid has been proved to improve the sensitivity of human body to insulin, which is effective for diabetes and metabolic syndrome without obvious side effects. At present, several large biopharmaceutical companies in the United States (Innovix Pharm Company, Tersus Pharmaceuticals Biopharmaceutical Company) and Nutrition Company (Source Natural Company, New Chapter Company Sibu Beauty Company), as well as Denmark's Pharma Nord company, etc. are vigorously developing palmitoleic acid-based omega -7 fatty acid health products and pharmaceutical preparations, and some products have been successfully marketed. In industry, palmitoleic acid can be directly used to efficiently produce octene, which is in high demand in industry. my country's population is rapidly aging, and the population suffering from metabolic syndromes such as diabetes and hyperlipidemia is growing rapidly, which will generate a huge demand for palmitoleic acid-based omega 7 fatty acid health products and pharmaceutical preparations. At the same time, palmitoleic acid is a monounsaturated fatty acid, which has very good low temperature resistance and antioxidant properties, and is suitable for preparing high-quality biodiesel. figure 1: palmitoleic acid |
| Source | So far, palmitoleic acid is mostly derived from biosynthesis. At present, wild plants are the main raw materials of palm oleic acid products. For example, Pharma Nord Company of New Chapter Company and Sibu Beauty Company Company all choose to extract and separate palmitoleic acid from seabuckthorn fruit. Seabuckthorn seeds contain only 4.4% palmitoleic acid , but 24.9% palmitoleic acid can be accumulated in its pulp. The oil of seabuckthorn pulp can be fractionated into liquid phase 20%) and solid phase, which can enrich 53% palmitoleic acid. In addition, the seeds of the woody vine, which is native to the Amazon rainforest, South America and Central America, contain 64% palmitoleic acid. Another tropical plant-macadamia nut has a palmitoleic acid content of 30%. |
| preparation method | the study of palmitoleic acid has not yet formed a system, and there are few reports on its purification and preparation. The current methods are mainly CO2 supercritical extraction and molecular distillation. The CO2 supercritical extraction method is a method that uses CO2 to form a supercritical fluid extraction to separate the corresponding components under a certain pressure and temperature. In the supercritical state, the CO2 supercritical fluid is contacted with the substance to be separated, and the polarity, boiling point and relative molecular mass can be selectively changed. Different components are extracted and separated. Chirada et al., apply this method to extract palmitoleic acid from sea buckthorn fruit oil , and the content of palmitoleic acid in the product can reach 55.24%. Molecular distillation is a method for separating fatty acids that has appeared in recent years. In the ultra-vacuum state, fatty acid molecules are heated to generate thermal movement, and different components are separated according to the distance of the thermal transport moving free path. |
| physiological function | the effect of palmitoleic acid on obesity: it is found that it can be used as a lipid hormone to regulate systemic metabolism, thus affecting the formation of fat and so on, thus having an effect on obesity. It was found that palmitoleic acid can affect PPAR-alpha-related enzymes, increase lipolysis and lipase mechanism of adipocytes, and further enhance systemic glucose metabolism, make liver steatosis and regulate triacylglycerol formation in adipocytes. In addition, palmitoleic acid can regulate the accumulation of plasma esters and interfere with diseases such as fatty liver and atherosclerosis. The effect of palmitoleic acid on neurons in the central system. It was found that the level of brain-derived neurotrophic factor is related to the content of intracellular palmitoleic acid, indicating that palmitoleic acid can regulate the lipid metabolism of brain nerves affecting cells. The effect of palmitoleic acid on hyperglycemia: Palmitoleic acid can increase the insulin sensitivity of muscles and counteract the insulin resistance caused by saturated fatty acids through activation of macrophages. In addition, palmitoleic acid has also been found to affect a variety of key enzymes in blood glucose metabolism and regulate insulin secretion in patients. Anti-inflammatory study of palmitoleic acid: Palmitoleic acid can regulate body metabolism, affect inflammatory markers and PPAR metabolic pathways, and have certain therapeutic effects on inflammation. The effect of palmitoleic acid on the skin: Palmitoleic acid can inhibit melanin factor in human cells and improve skin pigmentation. It is found that calcium palmitoleic acid has a good anti-Staphylococcus aureus and Propionibacterium acnes Antibacterial activity, and calcium palmitoleic acid can improve skin smoothness. figure 2: palmitoleic acid as pharmaceutical preparation |
| toxic and side effects | palm oleic acid can cause ATP loss and abnormal Ca2 pump, resulting in pancreatic acinar cell damage , which is a major cause of pancreatitis. It is found that palmitoleic acid has lipotoxicity in the presence of L-carnitine, which can cause changes in the permeability of cardiac mitochondrial membrane. |
| Application | In industry, 1-octene is commonly used as a plasticizer for polyethylene comonomer production, surface activity The raw material of sex agent and synthetic lubricating oil is quite economic value; and palmitoleic acid is considered to be a renewable resource of 1-octene. The monounsaturated structure of palmitoleic acid makes it have better antioxidant deterioration effect and lower freezing point. It is an ideal raw material candidate for biodiesel. In addition, it also has some applications in other fields. It is found that the use of palmitoleic acid in acid bubbles has better physical and chemical properties and packaging efficiency, and has good application value in the field of materials. |
| References | [1] Zhang Zesheng, Gao Shan, Guo Qing, et al. Research Status and Prospect of Palmitoleic Acid [J]. China Food Additives, 2016(9):198-202. [2] Wang Hui, Zhou Wenjun, liu Tianzhong. Production of Monounsaturated Fatty Acid from Microalgae-Palmitoleic Acid [J]. Biological Industry Technology, 2016(2):18-21. [3] Li Tao, Zhu Xiaohong, Sheng Xixia, et al. Method for Identification of Waste Oil Based on Double Indexes of Palmitoleic Acid and Isobutenal [J]. Food Science, 2013, 34(8):199-203. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.