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Hebei Nengqian Chemical Import and Export Co., LTD

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Hebei Nengqian Chemical Import and Export Co., LTD

Country: China (Mainland)

Business Type:Trading Company

Ms.Winnie

Tel: +86 18233902561

Mobile: +86 18233902561

Tel: +86 18233902561

Fax: 4001020630

URL: https://www.nengqianchemical.com/

Province/state: Hebei

City: Handan

Street: Congtai District, La Defense North

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(-)PPP

CAS NO.477-47-4

  • FOB Price: USD: 45.00-65.00 /Kilogram Get Latest Price
  • Min.Order: 5 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T
  • Available Specifications:

    medical grade(1-50)Kilogrammedical grade(50-500)Kilogram

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Product Details

Keywords

  • Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5a,5aa,8aa,9a)]-
  • PICROPODOPHYLLIN
  • Picropodophyllin(6CI,7CI,8CI)

Quick Details

  • ProName: (-)PPP 477-47-4
  • CasNo: 477-47-4
  • Molecular Formula: C22H22O8
  • Appearance: White powder
  • Application: Cytosine (C) is one of the four main b...
  • DeliveryTime: 5-7 woking day
  • PackAge: Brown vial or HDPE plastic bottle
  • Port: Qingdao port, Tianjin port
  • ProductionCapacity: 3000 Kilogram/Month
  • Purity: >99%
  • Storage: Cool Dry Place
  • Transportation: Bag or Drum
  • LimitNum: 5 Kilogram
  • packing: According to your request

Superiority

OEM Supply Superior Quality 99% Cytosine CAS 71-30-7

Basic Information:
 

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

Cytosine reagent is used in a wide variety of research applications, as an enzyme-substrate or precursor of effector molecules such as cytosine sugars.

Product Name: Cytosine
Synonyms: 4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE
CAS: 71-30-7
MF: C4H5N3O
MW: 111.1

 

Details

Molecular Formula C22H22O8
Molar Mass 414.41
Density 1.370
Melting Point 225-227℃
Boling Point 453.31°C (rough estimate)
Specific Rotation(α) D20 +9.4° (c = 0.7 in chloroform)
Solubility Soluble in DMSO, insoluble in water
Appearance Powder
Color white
pKa 13.26±0.40(Predicted)
Storage Condition Sealed in dry,2-8°C
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Sensitive Light Sensitive
Refractive Index 1.4480 (estimate)
MDL MFCD01742647
Physical and Chemical Properties White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from the rhizome of Berberis plant octagonal lotus Dysosma versipellis(Hance.)M.Cheng, peach seven.
In vitro study In intact cells, PPP potently inhibited IGF-1 of Akt (Ser 473) and Erk1/2 phosphorylation stimulated by IGF-1R. In IGF-1R positive tumor cells in culture, picropodophylin specifically inhibited cell growth and induced apoptosis. Picropodopylin synergistically sensitized HMCL, primary human MM and mouse 5T33MM cells to ABT-737 and ABT-199 by further reducing cell viability and enhancing apoptosis. Picropodopylin and sorafenib synergistically inhibit the proliferation and activity of hepatocellular carcinoma.
In vivo study In SCID mice xenografted with human ES-1,BE, and PC3, Picropodophyllin (20 mg/kg/12 h, I. p.) caused complete tumor regression. In the 5t33mm mouse model, Picropodophyllin also showed potent anti-tumor activity and significantly increased survival.

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