Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.480-19-3
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C16H12O7 |
| Molar Mass | 316.26 |
| Density | 1.634±0.06 g/cm3(Predicted) |
| Melting Point | 307°C |
| Boling Point | 599.4±50.0 °C(Predicted) |
| Flash Point | 227.8°C |
| Solubility | Slightly soluble in water and methanol, soluble in mixed solvent of methanol and chloroform, soluble in DMSO. |
| Vapor Presure | 5.79E-15mmHg at 25°C |
| Appearance | Pale yellow needle crystal |
| Color | Light yellow to Amber to Dark green |
| BRN | 44723 |
| pKa | 6.31±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.74 |
| MDL | MFCD00017310 |
| In vitro study | Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC 50 , ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC 50 , 38 µM). |
| In vivo study | Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm 3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm 3 , respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group. |
| Plant source: | Seabuckthorn |
| overview | isorhamnetin (Isorhamnetin,Iso) is a flavonoid compound isolated and purified from medicinal plants such as ginkgo biloba and seabuckthorn, and is also widely found in flowers, fruits and leaves of many other plants. It has good anti-tumor, anti-myocardial hypoxia, ischemia, relieve angina pectoris, anti-arrhythmia, treat coronary heart disease and hypertension, scavenge oxygen free radicals, reduce serum cholesterol, protect cardiovascular, promote blood flow, etc. A variety of biological effects are widely used in clinical practice. |
| physical properties | yellow needle crystal (dilute methanol),mp312 ℃ (decomposition). UV λmax (MeOH) nm: 257,370;(MeOH/NaOMe): 272,330,427 (decomposition);(MeOH/ AlCl3): 267,304 (sh),360,428. IRvmax (KBr)cm-1: 3242,2940,1657,1616,1603,1560,1508,1244,1211,1167. EIMS m/z: 316,315,153,151. 1HNMR. (2015-09-06) Figure 1 shows isorhamnetin |
| plant source: | isorhamnetin can be extracted from the following plants: 1. Elaeagnaceae: the plant seabuckthorn Hippophae the fruit of fhamnoides l. 2. Asclepiadaceae (Asclepiadaceae): Taiwan eye tree lotus Dischidia formosana maxim. Whole grass. 3. Bignoniaceae (Bingoniaceae): Huangzhong flower Tecomastans H. B. K. flower. 4. Euonymus (Celastraceae): Wild. leaves, the Maytenus emarginata of Meadeng wood. 5. Compositae (Compositae): Arnica longifolia D.C.Eaton flower; Artemisia annua L Artemisia leaves, stems: Artemisia annua Artemisia capillaris Thunb. 6. Cucurbitaceae (Cucurbitaceae): Gynostemma yixingense C. Y. Wu et S. K. Chen's overground part. 7. Leguminosae (Leguminosae): Sophora japonica Sophora japonica L. flower buds; Red clover Trifolium pratense L. petals. 8. Sapindus family (Sapindaceae): Chesangzi Dodonaea viscosa (L.) Jacq. Flowers. 9. Tamarix family (Tamaricaceae): Lour, Tamarix chinensis of Xihe Willow. Branches. 10. Taxus family (Taxaceae): Taxus brevifolia Taxus brevifolia Nutt. Leaves. 11. linden tree family (Tiliaceae): scum leaf Microcos paniculata L.12. cattail family (Typhaceae): long bract cattail typha angustata Bory et Chaub.; Typha angustifolia L.13. Umbelliferae (Umbelliferae): Wall. ex DC. var. giraldii Wolff, Bupleurum longicaule of Bupleurum in Qinling Mountains; Oenanthe javanica of cress. 14. Tribulus terrestris family (Zygophyllaceae): Nitraria tangutorum Bolor seeds. |
| pharmacological activity | 1. crown expansion. Increase coronary blood flow. 2. Inhibit platelet aggregation. 3. Anti-hemostatic effect. Inhibit the effect of certain hemostatic components. 4. Anti-liver toxicity components. It has an inhibitory effect on CCl4 and GalN-induced hepatocyte poisoning in rats. 5.V9Z: Regulate the reproductive ability of male plants. 6. Reduce cholesterol concentration in rat serum and liver. 7. Anti-lipid peroxidation. Reduce the amount of thiobarbituric acid reactive substance TBARS in rat liver. 8. Anti-tumor effect, isorhamnetin mainly inhibits tumor cell proliferation, induces cell apoptosis, inhibits signal transduction, etc., Isorhamnetin has a significant anti-breast cancer effect, and its mechanism of action is related to inhibiting cell proliferation pathway and promoting cell apoptosis. |
| extraction and synthesis method | extraction method of isorhamnetin in seabuckthorn pomace The principle of ultrasonic extraction of isorhamnetin is that ultrasound produces cavitation between the solvent and the sample, resulting in the formation, growth, blasting and compression of bubbles in the solution, which is helpful for solute diffusion and improves the mass transfer rate of the target from the solid phase to the liquid phase. Ultrasonic method can greatly shorten the extraction time, improve the rate of effective ingredients and the utilization rate of raw materials. The best process for accurately weighing about 1.0g of seabuckthorn pomace → adding extract → ultrasonic extraction → filtration → filtrate constant volume → isorhamnetin seabuckthorn pomace is as follows: under the condition of 50 ℃, ultrasonic frequency 40 kHz, ultrasonic extraction twice with the extract with V ethyl acetate: V 95% ethanol 4:6, 1 h each time, and the solid-liquid ratio is 1:25. The content of isorhamnetin extracted by this method can reach 5.09 mg · g-1. Chemical synthesis method: quercetin (Ⅰ) is used as the starting material to obtain quercetin pentaacetate (Ⅱ) and 4 ',7-di-O-benzyl quercetin (Ⅲ),4',7-di-O-benzyl quercetin triacetate (Ⅳ) and 4 ',7-di-O-benzyl -3'-methyl quercetin (Ⅴ) intermediates, respectively. Compound (Ⅴ) is subjected to benzylation reaction to obtain isorhamnetin (Ⅵ). |
| biological activity | Isorhamnetin is a flavonoid compound extracted from the Chinese herbal medicine Hippophae rhamnoides (Hippophae rhamnoides L.). Isorhamnetin can inhibit skin cancer by directly inhibiting MEK1 and PI3K. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.