Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.56-84-8
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molar Mass | 133.1 |
| Density | 1.66 |
| Melting Point | >300°C (dec.)(lit.) |
| Boling Point | 245.59°C (rough estimate) |
| Specific Rotation(α) | 25 º (c=8, 6N HCl) |
| JECFA Number | 1429 |
| Water Solubility | 5 g/L (25 ºC) |
| Solubility | Soluble in boiling water, slightly soluble in water (0.5%) at 25°C, easily soluble in dilute acid and sodium hydroxide solution, insoluble in ethanol and ether |
| Appearance | White crystal or crystalline powder |
| Color | White |
| Odor | acid taste |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.20', , 'λ: 280 nm Amax: 0.10'] |
| Merck | 14,840 |
| BRN | 1723530 |
| pKa | 1.99(at 25℃) |
| PH | 2.5-3.5 (4g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidising agents. |
| Refractive Index | 1.4540 (estimate) |
| MDL | MFCD00002616 |
| Physical and Chemical Properties | Melting point 230°C specific optical rotation 25 ° (c = 8, 6N HCl) water-soluble 5g/L (25°C) |
| Use | Used for synthetic sweeteners, medicine for the treatment of heart disease, used as liver function promoter, ammonia antidote, fatigue remover and amino acid infusion components |
td is used in biochemical studies, as a fatigue recovery agent, ammonia antidote, and as a clinical diagnostic agent.
| chemical properties | White Crystal or crystalline powder, slightly acidic taste. Soluble in boiling water, 25 ° C micro-soluble in water (0.5%), soluble in dilute acid and sodium hydroxide solution, insoluble in ethanol, ether, heated to 270 ° C decomposition, isoelectric point 2.77, the specific rotation is related to the dissolved solvent. In the acid solution, it is right-handed, the alkali solution is left-handed, and the aqueous solution is right-handed. [Α] 25D +5.05 (C = 0.5-2.0g/ml, H2O). |
| purpose | as the electrolyte supplement medicine in amino acid infusion, potassium, calcium and other inorganic ion supplements, fatigue recovery agent. Potassium magnesium aspartate injection or oral liquid, for cardiac glycoside poisoning caused by arrhythmia and premature beat, tachycardia, hypokalemia, hypomagnesemia, heart failure, myocardial infarction, angina, hepatitis, cirrhosis and other diseases. Is low toxicity, the goods should not be injected without dilution, renal insufficiency and atrioventricular block with caution. |
| purpose | can be used as ammonia antidote, liver function promoter, fatigue recovery agent and other pharmaceuticals, can be prepared L-sodium aspartate food additives and additives for various cool drinks, can also be used as biochemical reagents, medium and intermediates in organic synthesis. |
| purpose | used for synthetic sweeteners, used in the treatment of heart disease in medicine, used as liver function promoter, ammonia antidote, fatigue remover and amino acid infusion components, etc. |
| purpose | nutritional supplement and flavoring agent. Added to a variety of cool drinks. It is used as ammonia antidote, liver function promoter and fatigue recovery agent in medicine. |
| purpose | |
| production method | with DL-aspartic acid as raw material, under the condition of pH>7, acylation reaction with chloroacetamide was carried out, followed by acidification, acetone extraction and activated carbon treatment, under the condition of pH = 7-7.2, the crude product was separated by renal acylase II, acidified by HCl, treated with activated carbon, and then purified and dried to obtain a finished product. |
| production method | a calcium salt of L-glutamic acid and L-aspartic acid is obtained from various L-aspartic acid-rich proteins by acid hydrolysis followed by neutralization with calcium hydroxide, and then separated. The yield was high by adding ammonia to fumaric acid with enzyme. Obtained from the fermentation of sugars by E. Coli. |
| production method | the preparation method of L-aspartic acid is a synthesis method and a fermentation method. The synthesis method is mainly based on maleic acid or fumaric acid or their esters as raw materials, under pressure with ammonia treatment, and then hydrolysis. Racemic aspartic acid can be easily synthesized, but there is no ideal method for resolving racemates. The product can be obtained in high yield by adding fumaric acid and ammonia under the action of enzyme. This method is the main method of industrial production because only the levorotatory body is produced and the yield is high. |
| production method | L-aspartic acid is mainly produced enzymatically. L-aspartic acid is produced by the action of L-aspartase on fumaric acid (trans-succinic acid) and ammonia. Culture culture of Escherichia coli as1.881. Ordinary broth medium is bevel medium, and the composition of the flask medium is: corn steep liquor 7.5%, fumaric acid 2.0%,MgSO4 · 7 H2O 0.02%. The solution is adjusted to pH 6.0 with ammonia, boiled and filtered, A 500ml Erlenmeyer flask was filled with 50-100ml of culture medium. Take the cultured seeds on the fresh slope or in the liquid, inoculate and shake the flask culture medium, shake the culture at 37 ℃ for 24h, and gradually expand the culture to the scale of 1000-2000L, the pH was adjusted to 5.0 with 1mol/L HCl, maintained at 45 ° C. For 1H, cooled to room temperature, and centrifuged in a rotary high-speed centrifuge to collect cells containing aspartase. The immobilized aspartate enzyme was made into a bioreactor. Coli wet bacteria 20kg, suspended in the culture supernatant after centrifugation 80L (or 80L physiological saline), heat preservation 40 ℃ and then add 90L heat preservation 40 ℃ 12% gelatin solution and 1.0% glutaraldehyde solution, after thoroughly stirring, it is allowed to cool and solidify, and then immersed in 0.25% glutaraldehyde solution. After overnight at 5 ℃, it is cut into small pieces of 3-5 mm3 in size, it was soaked in 0.25% glutaraldehyde solution at 5 ℃ overnight, then taken out to wash with distilled water and filtered to obtain immobilized E containing aspartase. Coli, which was loaded into a packed bioreactor for standby. The 1 mol/L ammonium fumarate (containing 1mmol/L MgCl2,pH8.5) substrate solution was converted and continuously flowed through the bioreactor at a certain space velocity (SV), the conversion solution was obtained by controlling the maximum conversion rate to be greater than 95%. Preparation and purification of crude product the conversion solution was gradually added with 1 mol/L HCl, adjusted to pH 2.8, left overnight at 5 °c for crystallization, filtered and washed with water, the product was dried by filtration and dried at 105 ° C. To obtain crude L-aspartic acid. The crude product is recrystallized with dilute ammonia water, dissolved into 15% solution (pH5.0) with ammonia water, then added with 1% activated carbon, heated at 70 ℃, stirred and decolorized for 1H, and then filtered to remove the slag while hot, the filtrate was cooled, incubated overnight at 5 °c for crystallization, and the crystals were taken by filtration and vacuum dried at 85 °c to obtain a finished L-aspartic acid product. |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | Peritoneal-rat LD50: 6000 mg/kg |
| flammability hazard characteristics | flammable; Toxic NOx smoke from combustion |
| storage and transportation characteristics | ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-10 22:29:15
| FEMA | 3656 | L-ASPARTIC ACID |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| identification test | 1% sample solution (5ml) was co-heated with ninhydrin test solution (TS -250), blue-purple should appear. |
| content analysis | same as "01107,DL-aspartic acid". |
| toxicity | can be used safely in foods (FDA § 172.320,2000). |
| usage limit | accounts for 7.0% of the total protein in food (including asparagine; FDA § 172.320,2000). FEMA(mg/kg): baked food, meat product, meat soup, condiment, 250; Non-alcoholic beverage 150. |
| Use | for electrolyte supplement medicine in amino acid infusion, potassium, calcium and other inorganic ion supplements, fatigue recovery agent, etc. Potassium magnesium aspartate injection or oral liquid, for cardiac glycoside poisoning caused by arrhythmia and premature beat, tachycardia, hypokalemia, hypomagnesemia, heart failure, myocardial infarction, angina, hepatitis, cirrhosis and other diseases. Is low toxicity, the goods should not be injected without dilution, renal insufficiency and atrioventricular block with caution. it can be used as ammonia antidote, liver function promoter, fatigue recovery agent and other pharmaceuticals, and can be used as L-sodium aspartate food additives and additives for various cool drinks. It can also be used as biochemical reagents, medium and intermediates in organic synthesis. It is used for synthetic sweeteners, for the treatment of heart disease in medicine, as a liver function promoter, ammonia antidote, fatigue eliminator and amino acid infusion component, etc. Nutritional supplement, dimmer flavor enhancer. Added to a variety of cool drinks. It is used as ammonia antidote, liver function promoter and fatigue recovery agent in medicine. used in biochemical research, used as fatigue recovery agent, ammonia antidote, clinical diagnostic drug. The major neurotransmitter that excites fast synapses |
| production method | acylation of DL-aspartic acid with chloroacetamide at pH>7, then after acidification, acetone extraction and activated carbon treatment, under the condition of pH = 7-7.2 with renal acylase II resolution, HCl acidification, activated carbon treatment to obtain the crude product, and then purified and dried to obtain the finished product. A calcium salt of L-glutamic acid and L-aspartic acid is obtained from various L-aspartic acid-rich proteins, which are hydrolyzed with acid and then neutralized with calcium hydroxide, and then separated. The yield was high by adding ammonia to fumaric acid with enzyme. Obtained from the fermentation of sugars by E. Coli. there are synthesis and fermentation methods of L-aspartic acid. The synthesis method is mainly based on maleic acid or fumaric acid or their esters as raw materials, under pressure with ammonia treatment, and then hydrolysis. Racemic aspartic acid can be easily synthesized, but there is no ideal method for resolving racemates. The product can be obtained in high yield by adding fumaric acid and ammonia under the action of enzyme. This method is the main method of industrial production because only the levorotatory body is produced and the yield is high. L-aspartic acid is mainly produced by enzymatic method. L-aspartic acid is produced by the action of L-aspartase on fumaric acid (trans-succinic acid) and ammonia. Culture culture of Escherichia coli as1.881. Ordinary broth medium is bevel medium, and the composition of the flask medium is: corn steep liquor 7.5%, fumaric acid 2.0%,MgSO4 · 7 H2O 0.02%. The solution is adjusted to pH 6.0 with ammonia, boiled and filtered, A 500ml Erlenmeyer flask was filled with 50-100ml of culture medium. Take the cultured seeds on the fresh slope or in the liquid, inoculate and shake the flask culture medium, shake the culture at 37 ℃ for 24h, and gradually expand the culture to the scale of 1000-2000L, the pH was adjusted to 5.0 with 1mol/L HCl, maintained at 45 ° C. For 1H, cooled to room temperature, and centrifuged in a rotary high-speed centrifuge to collect cells containing aspartase. The immobilized aspartate enzyme was made into a bioreactor. Coli wet bacteria 20kg, suspended in the culture supernatant after centrifugation 80L (or 80L physiological saline), heat preservation 40 ℃ and then add 90L heat preservation 40 ℃ 12% gelatin solution and 1.0% glutaraldehyde solution, after thoroughly stirring, it is allowed to cool and solidify, and then immersed in 0.25% glutaraldehyde solution. After overnight at 5 ℃, it is cut into small pieces of 3-5 mm3 in size, it was soaked in 0.25% glutaraldehyde solution at 5 ℃ overnight, then taken out to wash with distilled water and filtered to obtain immobilized E containing aspartase. Coli, This was loaded into a packed bioreactor for standby use. The 1 mol/L ammonium fumarate (containing 1mmol/L MgCl2,pH8.5) substrate solution was converted and continuously flowed through the bioreactor at a certain space velocity (SV), the conversion solution was obtained by controlling the maximum conversion rate to be greater than 95%. Preparation and purification of crude product the conversion solution was gradually added with 1 mol/L HCl, adjusted to pH 2.8, left overnight at 5 °c for crystallization, filtered and washed with water, the product was dried by filtration and dried at 105 ° C. To obtain crude L-aspartic acid. The crude product is recrystallized with dilute ammonia water, dissolved into 15% solution (pH5.0) with ammonia water, then added with 1% activated carbon, heated at 70 ℃, stirred and decolorized for 1H, and then filtered to remove the slag while hot, the filtrate was cooled, incubated overnight at 5 °c for crystallization, and the crystals were taken by filtration and vacuum dried at 85 °c to obtain a finished L-aspartic acid product. |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | intraperitoneal-rat LD50: 6000 mg/kg |
| flammability hazard characteristics | flammability; Toxic NOx smoke from combustion |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.