Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.768-94-5
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molar Mass | 151.25 |
| Density | 0.9510 (rough estimate) |
| Melting Point | 206-208°C(lit.) |
| Boling Point | 263.29°C (rough estimate) |
| Flash Point | 96°C |
| Water Solubility | Soluble in organic solvents. Insoluble in water. |
| Solubility | Slightly soluble in water, soluble in chloroform |
| Vapor Presure | 0.0852mmHg at 25°C |
| Appearance | White to light yellow powder |
| Color | White to cream |
| Merck | 14,374 |
| BRN | 2204333 |
| pKa | 10.1(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.5220 (estimate) |
| MDL | MFCD00074732 |
| Physical and Chemical Properties | Melting point 180-192 ° C (sublimation), slightly soluble in water. |
| Use | For the production of synthetic adamantane derivatives amantadine hydrochloride and the like. |
| Background | amantadine was approved by the U. S. Food and Drug Administration as a prophylactic against influenza in October 1966, it was subsequently approved for the treatment of influenza Virus in adults. The drug was found to relieve symptoms of Parkinson's disease, a drug-induced extrapyramidal syndrome, in 1969. The U. S. Food and Drug Administration approved controlled release formulations of amantadine in 2017 for the treatment of dyskinesia in patients with Parkinson's disease. |
| mechanism of action | amantadine is a weak antagonist of NMDA-type glutamate receptors, increases the release of dopamine and blocks the reuptake of dopamine, as well as the anticholinergic effect of Trihexyphenidyl. The drug may also promote the release of norepinephrine from nerve endings in the brain. Can treat Parkinson's disease movement disorders, but also can improve Parkinson's disease long-term use of dopaminergic drugs after the emergence of dyskinesia. |
| precautions | the effect of amantadine may be weak, and patients with severe symptoms need to be combined with other drugs; amantadine may cause hallucinations and other reactions, especially in patients with decreased intelligence, advanced age, rigidity, middle and advanced stage, etc. The anti-abnormal effect of amantadine may be maintained for less than 1 year; A small number of patients taking amantadine may be abnormal urination, limb edema reaction; Night taking amantadine may affect sleep, or cause involuntary movements during sleep, should avoid taking medicine in the afternoon; taking amantadine needs to be increased from a small dose titration. |
| side effect | reticulate bruising of the skin, characterized by the appearance of reticular, slightly purple markings on the skin, mainly in the legs. Another common side effect is ankle edema, which may be a redistribution of body fluids and does not suggest cardio-renal insufficiency. Others such as dizziness, Sleep Initiation and Maintenance Disorders and neuroticism, Nausea, Vomit, anorexia, dry mouth, constipation. Occasional depression, Anxiety, hallucinations, confusion, ataxia, Head Pain, rare convulsions. Leukopenia and neutropenia were rare. |
| Use | antiviral, also anti-paralysis. It is used for the production of a synthetic adamantane derivative, amantadine hydrochloride, etc. structural units of catalysts for the synthesis of adamantane derivatives such as amantadine hydrochloride, the catalyst can be used for the enantioselective Strecker reaction of phosphonoimine |
| production method | is obtained by bromination of adamantane followed by reaction with urea. The process is as follows: the adamantane is added into a dry glass-lined reaction tank, bromine is added dropwise, the temperature is slowly raised, the temperature is increased from 50 ℃ to 65-75 ℃ in 1H, and the reaction is refluxed for 6H, the final temperature reached 110 °c (the boiling point of the material gradually increased as the reactants changed). The reaction was allowed to stand overnight. Then, the solution of 7% sodium bisulfite was added dropwise to remove excess bromine, filtered, and the filter cake was washed with water to pH = 7 and dried naturally to give bromoadamantane. The bromoadamantane and urea were mixed well and heated to 180 °c. The reaction was started and the internal temperature was increased to 230-240 °c. After completion of the reaction, the temperature was naturally lowered, concentrated hydrochloric acid was added and dissolved, and the mixture was transferred to a distillation tank, and sodium hydroxide was added for alkalization, followed by steam distillation to obtain amantadine. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.