Hebei Nengqian Chemical Import and Export Co., LTD
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CAS NO.83-86-3
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
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(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| What is phytic acid | phytic acid, also known as hexaethoxide hexaphosphate, exists in plant seeds in the form of calcium phytate and the like in nature. Phytic acid was extracted from rice bran and chaff. Because of its unique chemical properties and physiological functions, phytic acid has been widely used in food, medicine, metal processing, polymer industry, daily chemical industry and so on. Its molecule contains six phosphoric acid groups (12 free hydrogen), it is easy to combine with multivalent ions complexation reaction, complexation reaction is the formation of complexes. Value acid has a very strong complexation, can form insoluble complexes, so there will be a wide range of functions and uses. as an important natural substance, phytic acid is widely found in legumes, cereals, dried fruits, vegetables and fruits, especially in seeds, the seed is used to store phosphorus (at least 80% of the phosphorus in the grain is in the form of phytic acid), which has good stability and is not easy to rot. If it is combined with certain minerals such as magnesium, calcium, iron, zinc and other cations, the formation of phytate and fixed, therefore, phytate is a key factor in phosphorus nutrition and mineral nutrition. |
| skin care efficacy and function | value the principle of acid in skin care is somewhat similar to kojic acid, which can inhibit tyrosinase activity in vivo, thereby controlling the pigmentation of the skin. But because the value of the acid is extracted from plants, it is edible, so in the role of antioxidant and whitening when the sensitization rate is low, high safety, it is considered as an ideal alternative component of kojic acid. as early as the early 1995, phytic acid has been used as a skin whitening agent in clinical practice. In the process of melanin formation, it works by blocking the entry of iron and copper, this antioxidant effect is important for the skin and can help protect the skin from sun damage while lightening the dark complexion. The value of acid is used in all kinds of packaged food because of its characteristics in this regard, the seeds are not easy to decay because of the antioxidant effect of phytate, phytic acid is commonly used as a preservative in the food industry, the same mechanism is used to prevent food decay. The anti-oxidation and anti-free radical effect of phytic acid is due to the chelating property of phytic acid, because most oxidation processes in nature require metal ions as catalysts, which will produce highly active free radicals, after the complexation of iron ions, can reduce the generation of free radicals, but also slow down the oxidation reaction, and only calculate relatively stable. These effects have been concerned in the field of cosmetics, so the value acid component has been paid more and more attention in recent years. In addition, the value acid also has the effect of mild exfoliation. Compared with other acid components such as fruit acid, it will be much milder under the same PH condition. The acid binds to the calcium in the pores and softens it, Helps to make the pores temporarily smaller. Studies have also shown that phytic acid can reduce inflammation, so it is very suitable for people with sensitive skin or rosacea. |
| content analysis | weigh about 0.3g (to the nearest 0.0002g) and place in a 300ml Erlenmeyer flask, 10ml of nitric acid and 5ml of perchloric acid were added, and the mixture was heated in an electric furnace in a fume hood. The temperature was gradually raised to allow white smoke to escape until the solution was transparent and nearly dry, and cooled. The bottle wall was washed with A small amount of water, transferred quantitatively to A 100ml volumetric flask, and diluted to the scale with water to be solution A. Add 80ml of water, 10ml of nitric acid solution (TS-158), and 50ml of quinomolybdate limonone reagent (TS-202) into a 300ml Erlenmeyer flask. Heat and age the solution in a boiling water bath until it is clear, cool to room temperature. The precipitate was quantitatively transferred to a constant-weight sand-cored glass funnel, and the precipitate and the bottle wall were washed several times with a small amount of water. The funnel was dried in an oven at (120 2) °c for 1H, cooled to room temperature in a desiccator, and weighed. The percentage content (X1) of phytic acid (C6H18O24P6) is calculated according to formula (1): x1 = m1 × 0.01400 × 3.552/m× 20/100 × 100=24.86 × m1/m where m1-mass of sediment, g; m-mass of sample, g;0.01400-conversion factor of phosphorus and phosphorus, 30.974/2212.74;3.552-conversion factor of phosphorus and phytic acid, 660.04/ (30.974 × 6). The results should be expressed to one decimal place. The difference between two parallel determination results is not more than 0.3%, and the arithmetic mean value is taken as the determination result. |
| toxicity | LD50 4192mg/kg (mouse, oral). Chromosome Aberration Test of animal testis cells and animal bone marrow cells were negative. |
| usage limit | GB 2760-96: GMP for shrimp preservation; Edible oils, fruit and vegetable products, fruit and vegetable juices, meat products, 0.2 g/kg (residues less than or equal to 20 mg/kg). |
| Use | the food industry is used for the preservation and color protection of fruits, vegetables and aquatic products, and is also used for metal rust prevention, anti-oxidation agent has oxidation resistance and chelating effect, can be used for fruit and vegetable products, fruit and vegetable juices and beverages, edible oils and meat products, the maximum use of 0.2g/kg, can also be used for the preservation of shrimp, according to the production needs of the appropriate amount of use, the residue of 20 mg/kg. chelating agent; Antioxidant; Preservative; Color fixative; Water softener; Metal corrosion inhibitor and rust inhibitor; Fermentation accelerator. Can be used for canned aquatic products, fruits, agricultural products, beverages (cool drinks, milk drinks) and other to improve color, the amount of raw materials for the amount of 0.02% ~ 0.2%. The fermentation time can be shortened and the color and flavor can be improved by adding 0.01% ~ 0.05% of the raw material in the production of fermented products. The final content in the finished product should be less than or equal to 0.001% to 0.02%. It is also used to prevent the blackening of boiled shellfish, the fading of fruit juice, the occurrence of green spots in crab meat, and the production of magnesium ammonium phosphate glass-like crystals in aquatic cans. The product is mainly used as food additives and pharmaceutical raw materials. It can prevent the formation of magnesium ammonium phosphate crystals (MgNH4OP4 · 6H2O) in the can, that is, the so-called Struvite prevention agent, tin and other metal dissolution prevention agent and anti-browning agent; Used as a flavor enhancer of soybean paste, soy sauce, pickled products and discoloration, discoloration prevention agent; Oil Antioxidant; pH regulator, buffer; Bee head vegetables, burdock, bean sprouts and other agricultural products preservative; Chestnut, anti-browning agents for canned fruits such as pear, preservatives for pasta; Quality improvers for aquatic products; Anticoagulants; Stabilizers for vitamins B2, C, E, etc, sake, wine, anti-gold agent, anti-bacteriophage infection agent of wine such as brandy; Fermentation promoter. According to China's GB-2760-88 regulations, can be used for the preservation, the residue should not exceed 20ppm. In addition, industrial can also be used for rust inhibitor, detergent, explosion inhibitor, antistatic agent, paint, visualization agent, rare earth metal analysis reagent and so on. Especially in the application of cyanide plating solution, the metal surface treatment with phytic acid or sodium phytate instead of sodium cyanide is very remarkable. A mineral chelating agent that combines with a mineral to form a mineral-phytate complex. The conversion coating can also be formed by complexing with metal ions bound on the surface of the magnesium alloy, so that the resistance of the magnesium alloy to corrosion can be improved. |
| production method | widely exists in nature, but hardly exists in a single free state. Generally, the complex form of calcium, magnesium or potassium double salt (calcium hexaphosphate magnesium) and protein is widely present in plants, and it is often found in seeds, grains, embryos, rice bran. There are many reports on the preparation of this product. Rice bran or wheat bran is used as raw material, after being soaked in dilute acid, it is filtered, neutralized and precipitated with lime and sodium hydroxide, and then acidified and exchanged with ion exchange resin, concentrated under reduced pressure, decolorized and filtered to obtain the finished product. In addition, it is also possible to use a method of removing metal ions by chemical synthesis of cyclohexanol and inorganic phosphoric acid, or by using calcium magnesium phytate as a raw material. It can also be extracted from corn activated sludge. extracted from rice bran or cottonseed cake by acid leaching and alkali precipitation. Calcium magnesium phytate was heated in 2% HCl and treated with cation exchange resin. The crushed rice bran was soaked in dilute hydrochloric acid with pH value of 2 at 50~60 ℃ for 4~6h, the filter residue was soaked for 2H after filtration, and the waste residue was filtered, l0h was allowed to stand, and the supernatant was aspirated; Appropriate amounts of Ca(OH)2 and Mg(OH)2 were added to the supernatant, and the pH value was adjusted from 3.4 to 7.0 with NaOH solution, after stirring for 15min, the mixture was allowed to stand for 2-3H; The supernatant was discarded, filtered, and the residue was sequentially washed with aqueous alkali solution with pH value of 7.5 and distilled water to obtain calcium magnesium phytate in a yield of 95%-98%. Calcium magnesium phytate is dissolved in dilute hydrochloric acid solution with pH value of 3, and then soaked and stirred at 75 ℃ for 1 h to maintain pH value of 3.5-4.5, so that calcium magnesium phytate dissolves and protein precipitates. Adding 1% of the weight of the supernatant diatomite, stirring and static Suction filtration to remove protein and other precipitates; The filtrate sequentially passed through strong acidic cation exchange resin and strong basic anion exchange resin to obtain dilute phytic acid solution; it is concentrated under reduced pressure at 75 ° C. To a content of 55% to 65%. Put the above phytic acid solution into a polyol solvent (such as ethylene glycol, propylene glycol or glycerin), and heat and reflux at 130~150 °c for 3~4H, the pH value of the hydrolysate is adjusted to 8~9 at I00 ℃ ± 10 ℃, and then the mixture is stirred for 1 h while standing for filtration. The filtrate is heated to 135 ℃ for dehydration, and then 3 times the amount of anhydrous ethanol is added, the crystallization product is precipitated by standing. |
| Density | 1.432g/mLat 25°C |
| Melting Point | <25℃ |
| Boling Point | 105°C |
| Flash Point | 673.9°C |
| Water Solubility | MISCIBLE |
| Solubility | Easily soluble in water, ethanol and acetone, almost insoluble in ether, benzene and chloroform. |
| Vapor Presure | 0.039Pa at 60℃ |
| Appearance | The 70% is light yellow to light brown slurry liquid and the 98% is white powder. |
| Specific Gravity | 1.282 |
| Merck | 14,7387 |
| BRN | 2201952 |
| pKa | 1.13±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Thermal sensitivity |
| Refractive Index | n20/D 1.4 |
| MDL | MFCD00082309 |
| Physical and Chemical Properties |
trait light yellow to light brown serous liquid. density 1.285 |
| Use | The food industry is used for the preservation and color protection of fruits, vegetables and aquatic products, and is also used for metal rust prevention and resist. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.