Hebei Nengqian Chemical Import and Export Co., LTD
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- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.86087-23-2
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Molecular Formula | C4H8O2 |
| Molar Mass | 88.11 |
| Density | 1.103 g/mL at 25 °C (lit.) |
| Boling Point | 80 °C/15 mmHg (lit.) |
| Specific Rotation(α) | 18.5 º (c=2 MeOH) |
| Flash Point | 175°F |
| Water Solubility | soluble |
| Solubility | Chloroform, Methanol (Slightly) |
| Vapor Presure | 47Pa at 25℃ |
| Appearance | Liquid |
| Specific Gravity | 1.11 |
| Color | Clear colorless to pale yellow |
| BRN | 4652609 |
| pKa | 14.49±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.45(lit.) |
| Physical and Chemical Properties | Appearance colorless transparent liquid boiling range ℃(15mmHg) 79-80 |
| LogP | -0.784 at 22℃ and pH6.8 |
| surface tension | 72mN/m at 1g/L and 25 ℃ |
| introduction | (S)-( )-3-hydroxytetrahydrofuran is a colorless to pale yellow transparent liquid and can be used as a chemiluminescence analysis and detection reagent. |
| Uses | The synthesis of the anti-AIDS drug Ampunavir requires two important intermediates, one of which is (S)-() -3-Hydroxytetrahydrofuran. It can be synthesized by asymmetric borohydride or hydrosilicide of dihydrofuran, asymmetric hydrogenation reduction of 4-chloro3-carbonylbutyrate-intramolecular etherification, enzymatic resolution of 3-hydroxytetrahydrofuran racemate, etc. In most cases, the optical purity of the product is not enough. (S)-( )-3-hydroxytetrahydrofuran can be used as an intermediate of afatinib for the first-line treatment of advanced non-small cell lung cancer (NSCLC) and HER2-positive advanced breast cancer patients. |
| prepare | prepare dimethyl L-malate 2: dissolve 30gL-malic acid (0.224mol) in 90ml methanol, cool to -10 ℃, add 39ml dichlorosulfoxide (0.55mol) dropwise under stirring, and finish dropwise for 1.5h. Stir for 4h at room temperature, then heat reflux for 1h to stop the reaction. Concentrate under reduced pressure, add 125ml of 20% sodium carbonate solution, and adjust pH = 7. Extraction with ethyl acetate 3 times, 100ml each time. The ethyl acetate layer was combined, anhydrous magnesium sulfate was dried and concentrated under reduced pressure to obtain 33.68g of colorless oily liquid with 93% yield. Preparation of butyl alcohol 3:32.4gL-malate dimethyl ester (0.2mol) dissolved in 100ml methanol, adding 8.48g potassium borohydride (0.16mol) and 17g lithium chloride (0.4mol), heating reflux. After that, 4.24g of potassium borohydride (0.08mol) will be added every 20min for a total of 5 times. After the addition of continuous reflux for 3h,TLC detection of no raw material point, stop the reaction. A large amount of solid is filtered and removed first, the pH value of the filtrate is adjusted to 3 with sulfuric acid, the precipitated solid is filtered and removed again, and concentrated under reduced pressure. The resulting solid-liquid mixture was diluted, stirred, and filtered with 20ml of ethyl acetate and 20ml of ethanol. The filtrate is concentrated under reduced pressure to obtain 21g of yellow viscous liquid. Preparation of (S)-( )-3-hydroxytetrahydrofuran 4: The crude product obtained in the previous step was added to 2g(0.01mol) of p-toluenesulfonic acid monohydrate, dissolved by heating and continued to heat up to 200 ℃. Decompression fractionation (87 ℃/22mmHg), 7.6g of yellow oily liquid was collected, and the two-step yield was 43%. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.