Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.93-60-7
Industrial Grade(1-10)Metric TonIndustrial Grade(10-101)Metric TonIndustrial Grade(100-300)Metric Ton
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.
Consistent Quality
Our plant has strict quality control in each manufacturing process. Guaranteed.
Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.
Most competitive pricing
Our company is committed to the production and development of titanium dioxide, we always offer the most competitive pricing to customers to help lower their cost in application.
Shortest delivery time
90% of orders are shipped within 7-10 days after receipt of the prepayment or workable L/C.
Respond in 24 hours to inquiry, feedback or other requirements
Our experienced staff is dedicated to answer all of your inquires, feedback or other requirements in 24 hours.
We welcome you to contact us for more information and look forward to working with yo
Product introduction:
| Density | 1.2528 (rough estimate) |
| Melting Point | 42-44 °C (lit.) |
| Boling Point | 204 °C (lit.) |
| Flash Point | 204°F |
| JECFA Number | 1320 |
| Water Solubility | NEGLIGIBLE |
| Solubility | H2O: 0.1g/mL, clear |
| Vapor Presure | 0.4 hPa (25 °C) |
| Appearance | Yellow liquid |
| Color | White to brownish |
| Merck | 14,6100 |
| BRN | 113951 |
| pKa | pKa 3.1 (Uncertain) |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.5323 (estimate) |
| MDL | MFCD00006388 |
| Physical and Chemical Properties | Melting point 38-43°C boiling point 209°C flash point 95°C water-soluble neglignible |
| Melting point | 42-44 °C (lit.) |
| Boiling point | 204 °C (lit.) |
| density | 1.2528 (rough estimate) |
| vapor pressure | 0.4 hPa (25 °C) |
| FEMA | 3709 | METHYL NICOTINATE |
| refractive index | 1.5323 (estimate) |
| Fp | 204 °F |
| storage temp. | Store below +30°C. |
| solubility | H2O: 0.1 g/mL, clear |
| form | Crystals or Crystalline Powder |
| pka | pKa 3.1 (Uncertain) |
| color | White to brownish |
| Odor | at 10.00 % in dipropylene glycol. warm herbal tobacco |
| Odor Type | herbal |
| Water Solubility | NEGLIGIBLE |
| JECFA Number | 1320 |
| Merck | 14,6100 |
| BRN | 113951 |
| InChIKey | YNBADRVTZLEFNH-UHFFFAOYSA-N |
| LogP | 0.68 at 25℃ |
| CAS DataBase Reference | 93-60-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl nicotinate(93-60-7) |
| EPA Substance Registry System | Methyl nicotinate (93-60-7) |
| Methyl nicotinate Usage And Synthesis |
| Description | Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%). |
| Chemical Properties | Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor. |
| Occurrence | Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya. |
| Uses | Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla. |
| Definition | ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid. |
| Application | Methyl nicotinate can be employed as a precursor in the synthesis: Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains. 5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives. |
| Preparation | Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate. Synthesis and antinociceptive activity of methyl nicotinate DOI:10.4314/jpb.v12i1.8 |
| General Description | Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent. |
| Side effects | There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes. |
| Safety | No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248). |
| Synthesis | Methyl nicotinate is synthesized from Nicotinyl chloride hydrochloride and and Methanol in presence of Pyridine. |
| Carcinogenicity | No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.