Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.10040-45-6
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C18H13NO8S2.2Na |
| Molar Mass | 481.41 |
| Melting Point | 283-286°C |
| Solubility | Freely soluble in water, slightly soluble in ethanol 96 per cent. |
| Appearance | neat |
| Color | White to Off-White |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Sodium Picosulfate exhibited toxic effects in cultured hepatocytes. In rapidly growing cultured rabbit hepatocytes, 800 and 1600 mg/mL resulted in dose-dependent vacuolation and steatosis and necrosis, accompanied by a decrease in mitotic activity and a slight increase in LDH values. Significant but less severe effects were observed in rat hepatocytes cultured for 4 days, whereas hepatocytes cultured for 6 to 11 days tolerated 1600 mg/kg of Sodium Picosulfate. In human hepatocyte culture medium, cell numbers were slightly lower than 800 and 1600 mg/mL, and the number of nuclear divisions was dose-dependently reduced. |
| In vivo study | Long-term treatment with Sodium picosulfate had no effect on the neuropeptide content of the rat colon. Daily dose (10 mg/kg/day) or twice weekly dose (7.5 mg/kg/day) for more than 6 months the Sodium picosulfate did not affect vasoactive intestinal peptide (VIP), growth hormone inhibitors, and the levels of substance P in the mucosa, submucosa, or muscularis epidermis. Sodium picosulfate had no significant effect on the proliferation of epithelial cells of the ileum and colon. In the 12-week study, continuous treatment with 10 mg/kg Sodium picosulfate did not affect the labeling index of Brdu (LI) in the ileum in the treatment group compared with the control group, does not cause a statistically significant increase in LI. The pattern of proliferation along the crypts did not change throughout the sodium picosulphate treatment study. Long-term treatment with Sodium picosulfate does not cause chronic changes in colonic motility in rats. Pretreatment with 10 mg/kg/day Sodium picosulfate for 23 weeks did not cause significant changes in sustained spikes (LSB) in the fasted state or after ingestion of 3G food, it is associated with a phisic contraction or LSB frequency. |
| Introduction | The chemical name of sodium picosulfate (Sodiumpicosulfate) is 4,4 '(-pyridine-2-methylene-diphenyl) bisulfate sodium monohydrate, developed by DeAngeli, Italy. In May 1980, the drug was approved for marketing under the Laxoberon trade name, and has been widely used in Italy, Germany, Japan, Australia and other countries. In July 2012, the US FDA approved the listing of sodium picosulfate-magnesium oxide-citric acid oral powder (trade name: Prepopik). The drug has good clinical effects, small side effects, and high safety factor. As a toilet medicine taken once a day, sodium picosulfate has greater advantages in the treatment of constipation compared with domestic listed drugs, and the market prospect is broad. |
| pharmacological effects | studies have shown that sodium picronate has no gastrointestinal reaction, and diphenols are produced after hydrolysis of the hydrolase of the colonic flora to exert a laxative effect, among which sodium picronate exhibits a good laxative effect. The site of action of sodium picosulfate is the colon. After the enzyme hydrolysis produced by the colon flora, the active ingredient diphenols are produced, which can directly stimulate the intestinal mucosa, promote intestinal peristalsis and inhibit the absorption of water in the intestine, showing catharsis effect. Urinary excreta shows that sodium picosulfate has little absorption in the gastrointestinal tract, with little systemic effect, and its efficacy is independent of the plasma concentration of the active ingredient. |
| application | sodium pickle sulfate is a commonly used laxative in clinical practice abroad. the listed countries include Italy, Germany, Japan, Australia and other countries. Sodium picosulfate is a special laxative with a unique mode of action. It becomes a diphenol metabolite through the metabolism of the intestinal flora. This compound can make intestinal peristalsis hyperfunction, stimulate the intestinal mucosa, reduce water absorption, and produce catharsis. The catharsis effect is mild. It is suitable for various constipation, postoperative auxiliary defecation, promoting defecation after contrast agent administration, elimination of intestinal contents before surgery, and disposal before colorectal examination (endoscopy), exclusion of intestinal contents, etc. Sodium Picosulfate is a special laxative with a unique mode of action. It has a mild laxative effect on the large intestine mucosa. It can not only be used for various forms of constipation, but also can be used for hemorrhoids or anal fissure. It is also used for difficult defecation. |
| indications | sodium picosulfate is mainly used to treat various constipation clinically, such as postoperative auxiliary defecation, promoting defecation after contrast agent administration, elimination of intestinal contents before operation, pretreatment of large intestine examination (endoscope), elimination of intestinal contents, etc. |
| biological activity | Sodium Picosulfate is a kind of polyphenol irritant laxative, which can inhibit the absorption of water and electrolytes and increase their secretion. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.