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Ms.AnnaCAS NO.107534-93-0
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
OEM Supply Superior Quality 99% Cytosine CAS 71-30-7
Basic Information:
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).
Cytosine reagent is used in a wide variety of research applications, as an enzyme-substrate or precursor of effector molecules such as cytosine sugars.
| Product Name: | Cytosine |
| Synonyms: | 4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE |
| CAS: | 71-30-7 |
| MF: | C4H5N3O |
| MW: | 111.1 |
| Molecular Formula | C20H24O4 |
| Molar Mass | 328.4 |
| Density | 1.159 |
| Melting Point | 70-71℃ |
| Boling Point | 467.0±40.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.8 in CHCl3)+5.28 |
| Flash Point | 236℃ |
| Solubility | Soluble in chloroform, methanol |
| Appearance | White powder |
| pKa | 10.19±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD09953803 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from the root or skin of Schisandra chinensis Schisandra chinensis. |
| In vitro study | Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm 2 , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells. Cell Viability Assay Cell Line: Hacat cells Concentration: 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM Incubation Time: 72 hours Result: Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM. Western Blot Analysis Cell Line: Hacat cells Concentration: 0.1 μM; 0.5 μM;1 μM Incubation Time: 24 hours Result: Reduced UVB-induced COX-2 expression in cells. |
| In vivo study | Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice. Animal Model: Male C57BL/KsJ- db/db mice Dosage: 15 mg/kg Administration: Oral administration; 15 mg/kg; every day for three weeks Result: Significantly reduced the blood glucose levels in mice. |