Hebei Nengqian Chemical Import and Export Co., LTD
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CAS NO.118-10-5
Industrial Grade(1-10)Metric TonIndustrial Grade(10-101)Metric TonIndustrial Grade(100-300)Metric Ton
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Product introduction:
| Application | Cinchonine,(1S)-quinolin-4-yl (5-vinylquinin-2-yl) methanol, is a quinoline-type alkaloid, a kind of cinchona alkaloid, also known as cinchona, weak cinchona, is a stereoisomer of cinchona. Cinkonin is an alkaloid with more content except quinine in cinchona bark. Cinkonin is an essential analytical reagent for the determination of tungsten ore by gravimetric analysis. Cinkonin and its derivatives are widely used in the preparation, separation and analysis of chiral drugs and chiral intermediates. |
| anti-tumor application | the effect of cinkoning on tumor cell growth, and then it is determined that cinkoning can promote tumor cell apoptosis. the above experimental results show that cinkoning can inhibit tumor cell growth, promote early tumor apoptosis, enhance the expression of promoting cell apoptosis factors, and inhibit the expression of inhibiting apoptosis factors. Cinkonin is expected to be used in anti-tumor applications in the future. |
| preparation method | (1) preparation of raw material a: mixing cinchona bark (30-60 mesh powder) and toluene equivalent to 6 times the volume of cinchona bark, heating and refluxing at 80-90 ℃ for 4 times and then concentrating, and the total alkaloid extract obtained is dissolved in dilute sulfuric acid solution with a concentration of 10% by mass, the pH value of the solution is between 3 and 4, the filtrate is heated to 60~70 ℃ after filtration, sodium hydroxide with a concentration of 10% mass percentage is added under stirring to adjust the pH value of the solution to 6.5~7.0, and quinine sulfate is precipitated after standing for cooling, and quinine sulfate solid is filtered out. Then add sodium hydroxide solution with a concentration of 20% mass percentage to the filtrate to adjust the pH value of the solution to 10, place it, precipitate the total solids of the remaining cinchona alkaloids, filter out the solids, and then dry at 60~70 ℃ under normal pressure to obtain raw material A. (2) weigh 3.5g of raw material Ainto a 100mL round bottom flask, add 60mL of ethyl acetate, stir for 30min at room temperature, let stand for 6h, and filter to obtain filtrate B and insoluble substance c. Concentrate the filtrate B to one-tenth of the original volume and place it at room temperature until the crystallization is complete. After filtering out the crystallization, it is dissolved in ethanol solution with a volume fraction of 95%. 0.15 grams of activated carbon is decolorized and recrystallized to obtain 1.2 grams of white solid. The yield is 34%. It is white amorphous or crystalline powder, dissolved in ethanol, easily soluble in chloroform, and slightly soluble in ether, the specific rotation is 255 °(0.5mol/L ethanol solution), the melting point is 172-174 ℃, and the content determined by perchloric acid titration is 99.6%; the white solid sample is identified by thin layer chromatography The results are consistent with the standard, and the melting point of the sample is determined after mixing with the standard, which confirms that the white solid is quinidine. dissolve insoluble substance c with 95% volume fraction of ethanol, add 0.15g of activated carbon, keep 75 ℃ stirring for decolorization for 25 minutes, filter to remove activated carbon, and obtain 0.72g of white crystalline powder with 21% yield. The appearance of this product is white powder, dissolved in ethanol and chloroform, and slightly soluble in ether. The specific rotation is +225 (0.5mol/L ethanol solution), the melting point is 258-260 ℃, and the content is 98.5% by perchloric acid titration. The sample was identified by thin layer chromatography with the same results as the standard, the sample mixed with the standard after the determination of melting point does not change, the identification of the white powder for cinchonine. |
| Cinchona alkaloid | Cinchona is a quinoline-type alkaloid, a kind of Cinchona alkaloid, also known as Cinchona, weak Cinchona is the stereoisomer of Cinchona. Molecular formula C19H22N2O. Molecular weight 294.40. White needle-like or prismatic crystals obtained from ether. Melting point 58~60 ℃,[α]D15 48 (ethanol, C = 1). Sublimation begins at 220 ℃. Soluble in alcohol, ether, acetone, benzene and chloroform, almost insoluble in cold water. The color becomes darker under light, and its aqueous solution is mostly or almost completely converted into occinotoxin by phosphoric acid and organic acid (especially acetic acid) at 98~100 ℃, while no or only a small amount of this conversion occurs in hydrochloric acid. In hydrochloric acid or acetic acid, palladium-catalyzed hydrogenation obtains dihydrocinchonine, and in acetic acid, platinum-catalyzed hydrogenation at 50°C to obtain hexahydrocinchonine. This product naturally exists in the Rubiaceae cinchona plants. In 1820, French chemists Pierre Peltier (PierrePelletier) and Joseph Caventu (JosephCaventou) first separated from cinchona bark. Two active organisms (alkaloids), the active ingredients quinine and golden chicken ning (cinchonine), can treat various malaria clinically. It can also be used as bismuth and tungsten reagents. It can be obtained by reacting octanine ketone with ethanol and sodium, or reducing it with iron in acetic acid. |
| Use | Cinconine is a stereoisomerism of Cinconidine. Antimalarial drugs. |
| Production method | 1. Plant sources include the bark of red cinchona tree and cinchona bark of Rubiaceae. It can also be biosynthesized and can be made into hydrochloride and tartrate. It has anti-plasmodium and antipyretic effects. 2. Alkaloids can be obtained from the bark of cinchona after extraction. The crude product is dissolved in nitric acid and then precipitated with ammonia water. The white precipitate obtained is cinkonin. |
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.