Keywords

• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-
• 7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• (+)-Griseofulvin

Quick Details

• ProName: (+)-Griseofulvin 126-07-8
• CasNo: 126-07-8
• Molecular Formula: C17H17ClO6
• Appearance: Light yellow
• Application: It has inhibitory effect on all kinds ...
• DeliveryTime: 7-10 working days
• PackAge: In plastic outside weave or according ...
• Port: port of Qingdao、port of Tianjin
• ProductionCapacity: 500 Kilogram/Week
• Purity: >99%
• Storage: -15°C
• Transportation: We ship goods via DHL, Fedex, UPS, TNT...
• LimitNum: 1 Kilogram
• Grade: Industrial Grade,Food Grade,Pharma Gra...
• Shelf Life: Two years

Superiority

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

acidity

take this product 0.25g, add ethanol 20ml, shake, immediately add phenolphthalein indicator solution 0.1 ml and sodium hydroxide titration solution (0.02mol/L) titration to micro red, consumption of sodium hydroxide titration solution (0.02mol/L) should not pass 1.0ml.

clarity and color of solution

take 5 parts of this product, each 0.75g, respectively, plus N,N-dimethylformamide 10ml dissolved, the solution should be clear and colorless; If it is turbid, compared with No. 1 turbidity standard liquid (General rule 0902 first method), shall not be more concentrated; If color, compared with the yellow No. 3 Standard Colorimetric liquid (General rule 0901 first method), shall not be deeper.

particle size

weigh 10mg of this product accurately, add 2~4 drops of water to make it wet evenly, add 20 pieces of glass beads, shake for 3~5 minutes, then add 10ml of 5% gum arabic solution, fully shake for 10 minutes, immediately draw the Test solution from the bottom with a dropper, quickly wipe the outside of the dropper with filter paper, drop 1 drop vertically on the blood count plate, cover the cover glass, and examine it under the microscope, count, containing 5um and 5um particles should be not less than 85%, containing 50um and 50um particles, full view, not more than 5.

Related substances

take an appropriate amount of this product, add mobile phase A to dissolve and dilute to make A solution containing about 0.5mg per lml as A test solution; Take 1ml for precision measurement and put it in A 100ml measuring flask, dilute to the scale with mobile phase A, shake, as A control solution; Precision take the appropriate amount of control solution, quantitative dilution with mobile phase A to make A solution containing about 0.25ug per 1ml, as solution D for sensitivity, according to the test of high performance liquid chromatography (General rule 0512), with eighteen alkyl silane bonded silica gel as filler (4.6mm X, 5um or performance equivalent column); using 0.05mol/L potassium dihydrogen phosphate solution-acetonitrile-methanol (57:38:5 )(adjust pH to 3.7±0.2 with phosphoric acid) as mobile phase A, using 0.05mol/L potassium dihydrogen phosphate solution-acetonitrile methanol (28:68:8)(adjust pH to 3.7±0.2 with phosphoric acid) as mobile phase B, immediately after the completion of the elution of griseofulvin, the linear gradient elution was carried out according to the following table; The detection wavelength was 254mn. L01, the sensitivity solution is injected into the liquid chromatograph, and the chromatogram is recorded. The signal-to-noise ratio of the peak height of the principal component chromatogram should be greater than 10, respectively injected into the liquid chromatograph, record the chromatogram. If there are impurity peaks in the chromatogram of the test solution, the peak area of deschlorin (relative retention time is about 0.7) shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution, the Peak area of dehydrogriseofulvin (relative retention time is about 1.1) shall not be greater than 0.75 times (0.75%) of the main peak area of the control solution, and the sum of the peak areas of other impurities shall not be greater than the main peak area of the control solution (1.0%). The peaks in the test solution chromatogram which are smaller than the main peak area of the sensitivity test solution are ignored.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

not more than 0.2% (General rule 0841).

Heavy metals

The residue left under the item of ignition residue shall not contain more than 25 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Griseofulvin tablets

Authoritative Data Verified Data

This product contains griseofulvin (C17H17C106) should be labeled the amount of 90.0% ~ 110.0%.

trait

This product is white or off-white.

identification

In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.

examination

• Take 10 tablets of this product, grind them, take an appropriate amount (about 50mg equivalent to griseofulvin), put them in a 100ml measuring flask, add an appropriate amount of mobile phase, sonicate the griseofulvin and let it cool, dilute to the scale with mobile phase, shake, filter, as a test solution, according to the method under the item of griseofulvin, degassed griseofulvin peak area shall not be greater than 2.5 times (2.5%) of the main peak area of the control solution; Dehydrogriseofulvin peak area shall not be greater than 0.75 times (0.75%) of the main peak area of the control solution.
• dissolution: according to the dissolution and release determination method (General 0931 second method), 0.54% sodium dodecyl sulfate solution is used as the dissolution medium, and the rotation speed is 100 rpm, at 60 minutes, 10ml of the solution was filtered, and the appropriate amount of the filtrate was accurately taken and diluted with methanol-water (4:1) to prepare a solution containing about 5.6ug of griseofulvin per 1 ml. The absorbance was measured at a wavelength of 291mn according to UV-Vis spectrophotometry (General 0401), and the elution amount of each tablet was calculated as the absorption coefficient of C17H17C106 was 686. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
• others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 10 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about equivalent to 100mg of griseofulvin), put it in a 100ml measuring flask, add appropriate amount of mobile phase, ultrasonic to dissolve griseofulvin, allow to cool to room temperature, dilute to scale with mobile phase, shake well; Filter with 0.45um microfiltration membrane, Take 5ml of filtrate accurately, put it in 50ml measuring flask, dilute to scale with mobile phase, shake, as a test solution, according to the method under the item of griseofulvin, obtained.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.