Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 19831957301
Tel: +86 15632927689
Tel: +86 18233902561
Tel: +86 19903295909
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 15383190639
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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CAS NO.129453-61-8
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Melting Point | 104-106°C |
| Boling Point | 674.8±55.0 °C(Predicted) |
| Flash Point | 361.9°C |
| Solubility | DMSO: >5mg/mL |
| Vapor Presure | 3.95E-19mmHg at 25°C |
| Appearance | powder |
| Color | White |
| pKa | 10.27±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.521 |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| breast cancer treatment drug | fulvestrant is an intramuscular injection drug developed by AstraZeneca. It was approved by the U.S. Food and Drug Administration in April 2002. It is suitable for the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women who have deteriorated after anti-estrogen therapy. Many breast cancer cells have estrogen receptors (ER), which stimulate the growth of such tumors. Fluvestrant is a "pure" estrogen receptor antagonist with no partial estrogen-like agonistic effects. It inhibits the estrogen signaling pathway by binding, blocking and down-regulating the ER, and can compete with the ER The affinity with ER is close to estrogen, which is 100 times that of tamoxifen. It is the only anti-estrogen drug that can be widely used in clinical practice after the failure of tamoxifen, because the drug is endocrine therapy, it will not cause common adverse reactions of chemotherapy, so it has good patient compliance. Many clinical studies have found that the 250mg dose of fulvestrant has good therapeutic effect and stable safety in the second-line treatment of advanced breast cancer. |
| Mechanism of action | Fluvestrant is a steroid anti-estrogen drug. Its chemical structure is similar to estradiol. The difference is that it is at the 7α position. There is a linking group; it is an alkylamine analog of 17 β-estradiol, which can antagonize estrogen by occupying the ER and inhibit the activation of genes stimulated by this estrogen, therefore, estrogen-related processes necessary to affect cell circulation; its affinity with ER is close to estrogen, but it is 100 times that of tamoxifen. Apoptosis is crucial in maintaining homeostasis, and it may also be another major mechanism of the therapeutic effect of fulvestrant. |
| estrogen receptor antagonist | The breast cancer treatment drug fluvestrant developed by AstraZeneca Company is an estrogen receptor antagonist with low side effects. Its appearance means a major breakthrough in breast cancer treatment. Studies have shown that bone cells have typical estrogen receptors (ERs), and low estrogen status can lead to bone resorption and osteoporosis. Although fulvestrant has pure antagonistic activity, studies on ovariectomized rats show that it has no estrogen-like or anti-estrogen effect, while tamoxifen has estrogen-like effect and reduces periosteal formation. The fulvestrant also has significant activity against certain target organs other than breast tissue. For the endometrium, tamoxifen has partial agonistic activity, which will increase the incidence of endometrial cancer. However, the animal experiment of fulvestrum group did not show this adverse reaction. It not only shows a lack of activity on the uterus, but also It can block the mitogenic effect of tamoxifen on ovariectomized and estrogen-treated monkeys. |
| pharmacological effects | fulvestrant has relatively poor oral bioavailability, so it usually uses lipids as excipients for intramuscular injection. An open, randomized, multi-center study conducted in postmenopausal women with advanced breast cancer showed that there was no significant difference in pharmacokinetics and toxic side effects by injecting 250 mg of this product with a 5 ml or two 2.5 ml. The blood drug concentration was dose-dependent and individual differences; during the treatment period of 7 days, there was no significant change in serum LH, FSH or SBHG levels; the drug did not pass through the blood-brain barrier, it will not cause side effects such as vasomotor. Theoretically, estrogen inactivation can lead to an increase in bone turnover and promote osteoporosis. However, this effect has not been found in animal models, and fulvestrant has not caused an increase in bone turnover replacement markers. |
| adverse reactions | fulvestrant has fewer side effects, such as transient vaginal bleeding, body odor changes and sleepwalking state. However, there are no reports such as vaginal dryness, weight gain, abnormal blood coagulation, thrombosis and changes in libido, and facial flushing and sweating have not changed. A small phase III clinical trial showed that 19 women with metastatic breast cancer used this product. The clinical effective rate was 67%, and there were no serious safety problems, but it must be continuously injected monthly, and it is well tolerated. Only slight redness and pain occurred at the injection site. The subjects' facial flushing, endometrial thickness, sex hormone binding globulin levels, follicle stimulating hormone levels and luteinizing hormone levels did not change. |
| Production method | Add the corresponding dienone compound to the Grignard reagent (9-pentafluoropentyl thionyl bromide dissolved in the tetrahydrofuran solution containing magnesium chips, Add a small amount of iodine to initiate the reaction to prepare the Grignard reagent) solution. After the reaction is complete, the tetrahydrofuran solution with acetic acid is added to stop the reaction. Add water, evaporate tetrahydrofuran, add water, and extract with isohexane. After the extract is washed with potassium chloride aqueous solution, isohexane is distilled, acetonitrile is added, and copper bromide, lithium bromide and acetic anhydride are slowly added. The reaction liquid is put into a mixture of thiourea, toluene and water and cooled. Adjust the pH to 3 with dipotassium hydrogen phosphate, and filter to remove the precipitated copper. The filter cake is washed with toluene, the organic layers are combined, and washed with sodium chloride aqueous solution. Evaporate toluene, add methanol, add sodium hydroxide aqueous solution, and heat. The reaction solution is extracted with isohexane and neutralized with acetic acid. The methanol is distilled, and the resulting substance is distributed between water and ethyl acetate. Concentrate the organic layer, add ethyl acetate, acetic acid and hydrogen peroxide, and stir for reaction. Add ethyl acetate, and then add sodium sulfite aqueous solution to destroy excess hydrogen peroxide. Neutralize with sodium hydroxide, separate the organic layer, and wash with water. The solvent is distilled and seed crystals are added to promote crystallization. The crystallization is washed with cold ethyl acetate, and then recrystallized with ethyl acetate to obtain fulvestrant. |
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.