Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.140-82-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Density | 0.817g/mLat 25°C(lit.) |
| Melting Point | 37.5°C (estimate) |
| Boling Point | 101 °C / 37mmHg |
| Flash Point | 155°F |
| Vapor Presure | 2.39E-08mmHg at 25°C |
| Appearance | clear liquid |
| Specific Gravity | 0.82 |
| Color | Colorless to Almost colorless |
| Merck | 14,6723 |
| pKa | 10.81±0.35(Predicted) |
| Refractive Index | n20/D 1.4429(lit.) |
| Physical and Chemical Properties | Strong alkaline liquid with ammonia odor. boiling point 142~144 ℃ relative density 0.819 refractive index 1.4430 soluble in water, ethanol and ether. |
| Use | Intermediates for the manufacture of antimalarial drug chloroquine phosphate |
| Introduction | 2-amino-5-diethylaminopentane is a hydrocarbon organic, it can be prepared from diethylaminopentanol in one step. It has been reported in the literature that it can be used to prepare Nur77 receptor modulators. |
| preparation | catalyst preparation: Nickel nitrate containing 4.48% NiO,1.52% CuO and 2.82% ZrO2, the aqueous solution of copper nitrate and zirconium acetate was placed in a stirred vessel at a constant temperature while the aqueous solution of 20% sodium carbonate was kept at a constant temperature of 70 ° C. To maintain the pH measured with a 7.0 glass electrode. The obtained suspension was filtered and the filter cake was washed with deionized water until the conductivity of the filtrate was about 20 μs. This amount of ammonium heptamolybdate was then incorporated into the still wet filter cake to obtain the following specified oxide mixtures. The filter cake was then dried in a drying oven or spray dryer at a temperature of 150 °c. The hydroxide/carbonate mixture obtained in this way was then heated at a temperature of 500 °c for 4 hours. The catalyst thus obtained had the following composition: 50 wt% of NiO,17 wt% of CuO,1.5 wt% of MoO3 and 31.5 wt% of zro2. The catalyst powder was mixed with 3% by weight of graphite and a 6 × 3mm sheet deformation was made. The tablets had a porosity (measured by water absorption) of 0.20/g and a hardness of 3500N/cm2. reaction operation: 60 litres of catalyst (Type A) per hour in a continuously operated high pressure reactor at 200 bar and 155-157°C, 15 liters of diethylaminopentanol and 40 liters of ammonia (corresponding to a molar ratio of 1:20) were added every hour. At a conversion of 80%, the furnace discharge showed a product selectivity of 91%. |
| Use | is an intermediate in the manufacture of the antimalarial drug chloroquine phosphate pharmaceutical intermediate. For the manufacture of miparine hydrochloride, antimalarial drug chloroquine phosphate. intermediates for the manufacture of antimalarial drug chloroquine phosphate |
| production method | 5-diethylamino-2-pentanone dissolved in anhydrous ethanol, then, 5-diethylamino-2-pentanone, active nickel and anhydrous ethanol were added to the reaction tank and stirred, and liquid ammonia was introduced below 30 °c. The stirring was stopped, and the air was replaced 3 times with nitrogen, and the nitrogen was replaced 3 times with hydrogen. Hydrogen was supplied to 0.15MPa, pressurized to an internal pressure of 0.59MPa and an internal temperature of 95 ° C., and then maintained at 0.7-0.79MPa until hydrogen was no longer absorbed. After cooling, the hydrogen gas was discharged and replaced with nitrogen. The catalyst was filtered off, and ethanol was recovered from the filtrate under normal pressure. Then, a 94-130 ° C. (1.33kPa) fraction was distilled under reduced pressure to obtain 2-amino-5-diethylaminopentane. Yield 88% Product Specification: colorless transparent liquid, content ≥ 95%. Raw material consumption quota: 5-diethylamino-2-pentanone (87%)1016kg/t, liquid ammonia (industrial) 132kg/t, nickel aluminum alloy (industrial) 4kg/t, anhydrous ethanol (industrial) 364kg/t, hydrogen (99%)395. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.