Hebei Nengqian Chemical Import and Export Co., LTD
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Supplier - 4th
years
Assessed Supplier Enterprise Certification
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 19831957301
Tel: +86 15632927689
Tel: +86 18233902561
Tel: +86 19903295909
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 15383190639
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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CAS NO.14815-59-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molar Mass | 270.24 |
| Density | 1.3280 (rough estimate) |
| Melting Point | 255°C (dec.)(lit.) |
| Boling Point | 373.35°C (rough estimate) |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Solubility | Almost insoluble in water, soluble in ethanol and alkali solution. |
| Appearance | Orange-yellow long needle-like crystals (orange in acetone and yellow in methanol) |
| Color | orange |
| Merck | 14,3561 |
| BRN | 1888141 |
| pKa | 6.39±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to light and air |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00001207 |
| Physical and Chemical Properties | Orange needle-like crystals. Melting Point 256-257 °c (259-260 °c). Soluble in ethanol, slightly soluble in ether, chloroform, benzene, insoluble in water. Soluble in caustic aqueous solution, sodium carbonate solution, ammonia solution in the cherry red. |
| Use | Pharmaceutical intermediates intermediate; health products material |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| uses | emodin is a natural compound extracted from Chinese herbal medicines such as rhubarb and polygonum cuspidatum. it has many pharmacological effects such as anti-inflammatory, anti-virus and anti-tumor. Emodin is mainly used for antifeedant, anti-inflammatory, anti-mutation, antiseptic, anti-cancer (chest), anti-ulcer, anti-virus, cathartic, gonadotropic, anti-epidemic, insecticide, laxative, antispasmodic, hemostatic. This product can be used as a laxative. Although emodin has laxative activity, it is easy to be oxidized and destroyed in the body. In fact, the laxative effect is very weak. If it is combined with sugar to form glycosides, it can play a laxative effect. Emodin-1-O-β-D-glucoside and emodin-8-O-β-D-glucoside are glycosides that bind emodin and glucose. The two are only different in binding positions and exist in rhubarb. pharmaceutical intermediate intermediate; Health products material inhibits NF-κB activation and adhesion molecule expression. Casein kinase 2(CK2) inhibitors. |
| rhubarb | rhubarb is the dry rhizome of Rheum palmatum L., Rheum tanguticum Maxim. ex Balf. or Rheum officinale Baill. of medicinal rhubarb. The main difference between Tanggu extra-large yellow and palm-leaf rhubarb is that the leaves are deep 3-lobed and slender and feathery. Inflorescence branches tightly, often erect, close to the stem. The main difference between medicinal rhubarb and the above two rhubarb is that the leaves are lobed, the lobed slices are large-toothed or wide-triangular, the flowers are larger, yellow-white, and the flower buds are oval. There are about 60 species of rhubarb in the world and about 50 species in China. Form: Rhubarb is a tall perennial herb, about 2m high. Rhizomes and roots are thick and yellowish brown. Stems erect, smooth and glabrous, hollow. The basal leaves have long, fleshy thick stalks, about the same length as the leaves, the leaves are broadly ovate or nearly round, the diameter can reach 40cm, palmately half-lobed, lobes 3~5(-7), each 1 The lobes are sometimes feathered or coarsely toothed, and the base is slightly heart-shaped; the cauline leaves are smaller, with short stalks; the stipules are sheath-shaped, membranous, and densely pubescent. Habitat and distribution: born in mountain forest edge or grass slope, wild or cultivated. Distributed in Shaanxi, southeastern Gansu, Qinghai, western Sichuan, northwestern Yunnan and eastern Tibet. Cultivation: It is suitable for cool and humid climate, cold-resistant, and afraid of high temperature and humidity; it is better to plant sandy loam and calcareous loam with deep soil and rich humus. collection: from September to October, plants that have grown for more than 3 years are selected, rhizomes are excavated, stems and leaves, branches and roots are cut off, coarse skin and terminal buds are scraped off, air-dried, dried or sliced in the sun. Figure 1 is a picture of rhubarb. |
| Chemical composition of rhubarb | More than 130 compounds have been isolated and identified from various rhubarb, including anthraquinones and their glycosides, anthracenones, Dianthrone and its glycosides, stilbene and its glycosides and gallate, naphthalene derivatives, chromanone and its glycosides, phenylbutanone, tannins, etc. Among them, anthraquinones are important representative components. Free anthraquinone mainly includes rhein, emodin, physcion (Physcion), aloe-emodin (Aloe-emodin), chrysophanol (Chrysophanol), etc. Anthraquinone glycosides mainly include: chrysophane-1-glucoside, chrysophane-8-glucoside, emodin-1-glucoside, emodin-8-glucoside, physcion-8-glucoside, physcion-8-glucoside, physcion-8-gentiosides, aloe-emodin-8-glucoside, aloe-emodin-3-glucoside, rhein-8-glucoside, etc. Dianthrone glycosides include sennoside (Sennoside)A,B,C,D,E,F, etc. Stilbene and its glycosides include rhubarb glycoside (Rhaponticin), rhubarb glycoside (Rhapontigenin) and deoxyrhubarb glycoside (De-oxyrhaponticin). Rhubarb contains a variety of tannins that are hydrolyzable tannins and condensed tannins [4]. Hydrolyzed tannins and related compounds include a variety of galloyl glucose and 1-0galloyl-6-0-cinnamoyl-β-D-glucose (1). Condensation tannins and their related compounds include catechins, epicatechins and their multimers. In addition, rhubarb also contains a variety of phenylbutanone glycoside compounds. |
| anti-tumor effect | pharmacological studies have found that rhubarb anthraquinone derivatives, rhein, emodin and aloe emodin have obvious anti-cancer effects, and the more sensitive ones are melanoma, P388 leukemia and Ehrlich ascites cancer. Rhubarb polysaccharide has obvious inhibitory effect on sarcoma S180. Emodin concentration of 10 μg/mL can reduce the maximum growth density, division index and the incorporation of thymidine by tritium labeling method of human lung cancer A- 549 cells. The DNA content of the cells was significantly reduced. It was also found that this drug could increase G1 and S phase cells relatively, G2 M phase and aneuploid cells relatively reduced, and the peak value of the group diagram was left-handed and appeared on the lower channel. It shows that emodin has obvious inhibitory effect on the division of human lung cancer A- 549 cells. The anti-tumor mechanism of rhubarb is currently believed to inhibit the respiration of cancer cells and the biosynthesis of DNA. Some people think that rhein and emodin have a direct destructive effect on cancer cells. |
| diuretic effect | rhein and emodin have obvious diuretic effect. the increase of urine output reaches a peak 2~4 hours after taking the medicine, and the excretion of Na and k also reaches a peak. Aloe-emodin and chrysophanol have weak effects. The mechanism of action is due to the inhibitory effect of rhein and emodin on Na -K-ATPase in renal medulla. The reabsorption of Na in the renal tubules is mostly active transport, which requires the decomposition of ATP by Na -K-ATPase to provide energy. When this enzyme is inhibited, the energy source is insufficient, the reabsorption of Na is reduced, and Na carries water and is excreted diuresis. When the tubule Na increases, Na -K exchange is promoted, and K excretion also increases. |
| production method | emodin is widely found in plant laxatives, such as the rhizome of rhubarb, the bark and root bark of rhamnus, and the seeds of cassia. Emodin can be extracted from the rhizome of rhubarb. Emodin can also be prepared by synthesis, for example, with 2-methylanthraquinone, or with 3, 5-dinitrophthalic anhydride and m-cresol as raw materials, which can produce emodin. |
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.