Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.149647-78-9
medical grade(1-50)Metric Tonmedical grade(50-500)Metric Ton
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Molecular Formula | C14H20N2O3 |
| Molar Mass | 264.32 |
| Density | 1.2 |
| Melting Point | 161-162°C |
| Solubility | Soluble in ethanol (3 mg/ml at 25 °C), DMSO (53 mg/ml at 25 °C), DMF (~20 mg/ml). |
| Appearance | White crystalline solid |
| Color | white to tan |
| Merck | 14,10034 |
| pKa | 9.48±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.566 |
| MDL | MFCD00945317 |
| Physical and Chemical Properties | Appearance: white to off-white crystalline powder |
| In vitro study | Vorinostat is a small molecular weight (<300) linear oxime acid that inhibits HDAC activity, including the accumulation of acetylated histones and non-histones, inhibits the proliferation of cultured cells, and inhibits tumor growth. Vorinostat inhibits HDAC activity by binding to the active site of the enzyme. Vorinostat inhibits the proliferation of a variety of transformed cells (including lymphoma, multiple myeloma, leukemia, and non-small cell lung cancer) at concentrations ranging from 0.5 to 10 μm for 50% growth compared to controls. Vorinostat acts on lymphoma and leukemia cells, including Burkitt, B- cell acute lymphoblastic leukemia (B-ALL), MCL, DLBCL, ATL, and T-cells, and inhibits cell proliferation to varying degrees. In addition to inhibiting the proliferation of transformed cells, Vorinostat also inhibits normal cell proliferation by comparing Vorinostat's effects on a group of cell lines-normal human non-fibroblasts (WI-38) and SV40 giant T antigen transformed WI-38(VA-13). And get proven. Vorinostat inhibited the proliferation of both cell types in a dose-dependent manner. However, Vorinostat was found to have selective toxicity to transformed cells, including the death of tumor cells, while it only inhibits normal cells and does not cause death. The combination of Genistein and Vorinostat is much more effective than the combination of 5-aza and Vorinostat in inducing cell death. The combination of Genistein and Vorinostat reduces proliferation by 80% in ARCaP-E cells and by more than 60% in ARCaP-M cells. The combination of Genistein and Vorinostat has a synergistic effect on inhibiting cell proliferation. Acting on ARCaP-E cells (820 gene induction and 1046 gene suppression) ARCaP-M cells, Vorinostat affects more genes than Genistein. Vorinostat acts on the surface of tumor cells to increase the level of Fas protein in a dose-dependent manner, and when treated at a dose of 0.75 μm, the increase reached a stable level. Vorinostat inhibited tumor cell growth, including NB4, H460 and HCT-116, with IC50 of 0.7 μm, 3.4 μm and 1.2 μm, respectively. |
| In vivo study | Both Decitabine and Vorinostat have the function of causing tumor regression. However, the combination of Decitabine and Vorinostat had a stronger effect on tumor regression. Without any treatment, no significant difference in lung tumor burden was observed in wild-type and Fasgld mice. However, the combination of Decitabine and Vorinostat treatment of wild-type mice led to greater tumor regression than the treatment of Fas. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.