Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.154229-19-3
medical grade(1-50)Metric Tonmedical grade(50-500)Metric Ton
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Molecular Formula | C24H31NO |
| Molar Mass | 349.52 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Melting Point | 227-228 °C(Solv: toluene (108-88-3)) |
| Boling Point | 500.2±50.0 °C(Predicted) |
| Flash Point | 256.3°C |
| Solubility | DMSO 0.1 mg/mL Water 0.02 mg/mL Ethanol 0.2 mg/mL |
| Vapor Presure | 7.99E-11mmHg at 25°C |
| Appearance | Solid |
| Color | White to Pale Yellow |
| pKa | 14.71±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.605 |
| Use | Androgen antagonists |
| In vitro study | Abiraterone binds to wild-type and mutant androgen receptors (AR). In Vitro, Abiraterone inhibits proliferation and androgen receptor-regulated gene expression in androgen receptor-positive prostate cancer cells, explaining the mechanism by inhibition of steroid and antiandrogen receptors. In fact, the mutant androgen receptor activated by Eplerenone can be inhibited by higher concentrations of Abiraterone. The Abiraterone replaces the ligand in WT-AR and T877A with an EC50 of 13.4 μm and 7.9 μm, respectively. Abiraterone acts on rat testis microparticles and inhibits lyase activity with an IC50 of 5.8 nM. Abiraterone acetate significantly inhibited T secretion (− 48%) and in turn increased LH concentrations. (192 percent). |
| In vivo study | In human testis microsomes, Abiraterone inhibits CYP17 with an IC50 of 72 nM. Abiraterone did not significantly reduce any organ size. Abiraterone strongly reduces the level of testosterone, almost to the level of removal of the testicles. Compared with the control group, Abiraterone reduced testosterone levels by more than 95%. |