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Country: China (Mainland)
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Province/state: Hebei
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Street: Congtai District, La Defense North
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CAS NO.17455-13-9
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
Name | Theophylline |
Synonyms | accurbron Theophylline Acet-theocin dimethylxanthine 1,3-dimethyl-xanthin Theophylline anhydrous 3h)-dione,1,3-dimethyl-purine-6(1h 3,7-dihydro-1,3-dimethyl-1h-purine-6-dione 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione 6-dione,3,7-dihydro-1,3-dimethyl-1H-Purine-2 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl- 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione |
CAS | 58-55-9 |
EINECS | 200-385-7 |
InChI | InChI=1/C7H10N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3-5H,1-2H3,(H,8,9) |
InChIKey | ZFXYFBGIUFBOJW-UHFFFAOYSA-N |
Molecular Formula | C7H8N4O2 |
Molar Mass | 180.16 |
Density | 1.3640 (rough estimate) |
Melting Point | 271-273°C |
Boling Point | 312.97°C (rough estimate) |
Flash Point | 11°C |
Water Solubility | 8.3 g/L (20 ºC) |
Solubility | Soluble in water, ethanol, chloroform, soluble in alkali, ammonia and dilute acid, insoluble in ether. |
Vapor Presure | 2.72E-06mmHg at 25°C |
Appearance | White to off-white crystalline powder |
Color | white |
Merck | 14,9285 |
BRN | 13463 |
pKa | 8.77(at 25℃) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Sensitive | Sensitive to air |
Refractive Index | 1.6700 (estimate) |
MDL | MFCD00079619 |
Physical and Chemical Properties | White Crystal or crystalline powder, odorless, bitter taste. Mp270-274. It is soluble in water (1:120), ethanol (1:18), chloroform (1:86), alkali hydroxide, ammonia, dilute hydrochloric acid and dilute nitric acid at room temperature, slightly soluble in ether. Moderate toxicity, LD50 (rat, oral) 300mg/kg. |
Use | Mainly used for the treatment of bronchial and cardiac asthma, can also be used for cardiac edema |
Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 1 |
RTECS | XH3850000 |
FLUKA BRAND F CODES | 10-23 |
TSCA | Yes |
HS Code | 29395900 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 oral in rabbit: 350mg/kg |
Reference
Show more |
1. Dong Yanru, Cao Yanyan, Lu Jiachun, Mei Sifan, he run, Chen Ping. Crystallographic study of catechin-caffeine complex... |
Authoritative Data Verified Data
This product is 1, 3-dimethyl-3, 7-dihydro-1h-purine-2, 6-dione monohydrate or anhydrous. Calculated as dry, containing no less than 99.0% anhydrous theophylline (C7H8N4O2).
58-55-9 - Trait
Authoritative Data Verified Data
Authoritative Data Verified Data
Authoritative Data Verified Data
acidity
take 0.10g of this product, dissolve 25ml of heated water, add 1 drop of Methyl red indicator solution and 0.02 ml of sodium hydroxide titration solution (0.20 mol/L), which should be yellow.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing 2mg per 1 ml as a test solution; Take appropriate amount of precision, A solution containing 10ug per lml was prepared by quantitative dilution with mobile phase as a control solution. An appropriate amount of theophylline and theobromine was separately taken, and the mobile phase was added to dissolve and dilute to prepare a solution containing 10ug per lml, as a system suitability solution. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Acetate buffer solution (1.36g of sodium acetate was taken, of water was added to dissolve, and 5ml of glacial acetic acid was added, then diluted to 1000ml with water, and the mobile phase was acetonitrile (93:7). The detection wavelength was 271nm. The applicable solution 20 u1 of the system is injected into the liquid chromatograph, and the chromatogram is recorded. The number of theoretical plates is not less than 5000 calculated by theophylline peak, and the separation degree between theobromine peak and theophylline peak should be greater than 2.0. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.2 times (0.1%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 9.5%; For anhydrous theophylline, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add water 50ml, slightly dissolve, cool, add silver nitrate titration solution (0.lmol/L)25ml, plus bromothymol blue indicator solution 1ml, shake, with sodium hydroxide titration solution (0.1 mol/L) titration to a blue color of the solution. Each 1ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.02mg of C7H8N402.
Authoritative Data Verified Data
smooth muscle relaxant.
Authoritative Data Verified Data
sealed storage.
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging:
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage:
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery:
Usually within3-5 working days after full payment.
transport:
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.