Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.179324-69-7
Pharmaceutical grade(1-5)KilogramPharmaceutical grade(6-99)Kilogram
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| Molecular Formula | C19H25BN4O4 |
| Molar Mass | 384.24 |
| Density | 1.214 |
| Melting Point | 122-124°C |
| Solubility | Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol. |
| Appearance | Yellow solid |
| Color | White |
| pKa | 9.66±0.43(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Hygroscopic and Moisture Sensitive |
| Refractive Index | 1.564 |
| In vitro study | Bortezomib, a boronic acid dipeptide, is a highly selective reversible inhibitor of the 26S proteasome, which acts on the degradation of misfolded proteins and is essential for cell cycle regulation. Exposure to Bortezomib stabilized p21,p27, and p53, as well as pro-apoptotic Bid and Bax proteins, microvesiculin-1, and inhibitor κB-α, this prevents activation of the cell survival pathway induced by nuclear factor kappa B. Bortezomib also promotes pro-apoptotic c-Jun-NH2 terminal kinases, as well as activation of the endoplasmic reticulum stress response. Alterations in the levels of these cellular proteins result in inhibition of proliferation, migration, and promotion of apoptosis in cancer cells. Bortezomib was able to penetrate cells and inhibited proteasome-mediated intracellular long-lived proteolysis at a concentration of ∼ 0.1 μm for 50% inhibition of proteolysis. The IC50 value of Bortezomib for a panel of 60 cancer cell lines derived from multiple human tumors of the National Cancer Institute (NCI) was 7 nM. Treatment of PC-3 cells with Bortezomib (100 nM) for 8 H resulted in accumulation of cells in the G2-M phase and a corresponding decrease in the number of cells in the G1 phase. Bortezomib kills PC-3 cells at 24 and 48 hours with IC50 of 100 and 20 nM, respectively. Bortezomib induces nuclear condensation 16-24 hours after treatment. Bortezomib caused cleavage of PARP in a time-dependent manner at concentrations as low as 100 nM, producing effects after 24 hours of treatment. |
| In vivo study | The anticancer effects of Bortezomib monotherapy have been demonstrated in xenograft models of multiple myeloma, adult leukemia, lung, breast, prostate, pancreatic, head and neck, and colon cancers, as well as in melanoma. In the Lewis lung cancer model, oral administration of bortezomib (1.0 mg/kg, daily) for 18 days caused a delay in tumor growth and reduced the number of metastases. Bortezomib monotherapy significantly reduced breast cancer cell survival at doses up to 5 mg/kg. In a mouse xenograft model of prostate cancer, administration of Bortezomib (1.0 mg/kg once weekly) for 4 weeks reduced tumor growth by 60%. 1.0 mg/kg Bortezomib administration for 4 weeks resulted in a 72% or 84% reduction in xenograft growth in mice with pancreatic cancer and an increase in tumor cell apoptosis. 1.0 mg/kg Bortezomib significantly inhibited human plasmacytoma xenograft growth, increased tumor cell apoptosis and overall survival, and reduced tumor angiogenesis. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
6. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
7. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
8. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
9. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
10. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.