Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.29838-67-3
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Molecular Formula | C21H22O11 |
| Molar Mass | 450.4 |
| Density | 1.74 |
| Melting Point | 180 °C (decomp) |
| Boling Point | 801.1±65.0 °C(Predicted) |
| Flash Point | 282.9°C |
| Solubility | Easily soluble in boiling water, almost insoluble in ether |
| Vapor Presure | 4.42E-27mmHg at 25°C |
| Appearance | Colorless crystal |
| pKa | 7.34±0.60(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.748 |
| MDL | MFCD20274680 |
| Physical and Chemical Properties | White crystalline powder, soluble in boiling water, almost insoluble in ether, from Smilax, Smilax, Huangqi Engelhardtia roxburghiana Wall. |
| In vitro study | Astilbin is a common dietary flavonoid that can be found in various kinds of herbs and foods such as Smilax Glabra , Sarcandra glabra , grape and red wine. Astilbin markedly inhibits cisplatin-induced cell apoptosis and recovers cell growth. Astilbin significantly decreases reactive oxygen species (ROS) accumulation and alleviates ROS-induced activation of p53, MAPKs and AKT signaling cascades, which in turn attenuates cisplatin-induced HEK-293 cell apoptosis. Astilbin effectively enhances NRF2 activation and transcription of its targeting antioxidant genes to reduce ROS accumulation in cisplatin-induced HEK-293 cells. Astilbin obviously suppresses tumor necrosis factor alpha (TNF-α) expression and NF-κB activation, and also inhibits the expression of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). To measure the effects of Astilbin on the growth of CDDP-treated renal cells, HEK-293 cells are treated with CDDP (100 μM) and/or Astilbin (200 μM). Astilbin treatment significantly improvescell growth in CDDP-induced HEK-293 cells. |
| In vivo study | To explore whether Astilbin improves CDDP-induced nephrotoxicity in vivo, an acute cisplatin nephrotoxic mouse model is established. Single injection of CDDP with 8 mg/kg dose results in notable weight loss compared with control group. However, the phenomenon is significantly alleviated by Astilbin at dose of 50 mg/kg. The mice fed Astilbin alone do not show any obvious alteration in body weight. Similarly, serum creatinine (SCr) and blood urea nitrogen (BUN) are higher in CDDP-treated mice than in control group. Treatment with Astilbin also decreases SCr and BUN levels. To examine the protective effect of Astilbin on CDDP-induced renal histopathological damage, the mouse kidney sections are stained with H&E. The mice in control group and Astilbin treated group have normal kidney morphology, while kidneys in CDDP group show severe damage with tubular degeneration, necrosis and cystic dilatation of the tubules with focal hemorrhages. Administration of Astilbin mitigated kidney injury, resulting in lower histopathological score compared to CDDP group. The apoptosis of renal cells is also detected using TUNEL staining to determine whether Astilbin treatment decreased renal cell apoptosis in CDDP-induced acute nephrotoxic mice. |
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29389090 |
| Reference
Show more |
1. Jiang Xuanyu, Wang Siwei, Lou Lijun, etc. Effect of astilbin, an active molecule of Smilax glabra, on apoptosis of hu... |
| physiological effects | Smilax glabra Roxb., a Liliaceae plant, is a dried rhizome of Smilax glabra Roxb., which is a commonly used Chinese herbal medicine and has the effects of dehumidification and detoxification. Taxus leaf 3-O rhamnoth methyl ester (astilbin) is a flavonoid compound isolated from Smilax glabra. It has insecticidal, coenzyme A reductase, aldose reductase, hepatoprotective, analgesic, anti-edema, antioxidant and other active effects. Taxus leaf 3-O rhamnyl methyl ester can also significantly improve immune liver injury, induce apoptosis of PHA-activated Jurkat cells, inhibit delayed hypersensitivity and treat collagen arthritis in mice by inhibiting the function of activated T lymphocytes. |
| biological activity | Astilbin is a flavonoid compound that can be separated from the rhizome of Smilax glabra. Astilbin enhanced NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| use | astiloside has the effects of protecting liver, analgesia and anti-edema. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It can inhibit coenzyme A reductase, inhibit aldose reductase, protect liver, relieve pain, anti-edema, etc. In recent years, it has been reported that astilin has a significant selective immunosuppressive effect, and its selective effect has obvious advantages compared with previous immunosuppressants, so it can be used as a new immunosuppressant for the treatment of immune-related diseases. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.