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CAS NO.30123-17-2
Pharmaceutical grade(1-9)KilogramPharmaceutical grade(10-99)Kilogram
CAS 30123-17-2 on hot selling Tianeptine sodium White powder
Tianeptine sodium salt is a tricyclic antidepressant. Its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic space and may increase 5-HT nerves.
The effect of meta-conduction.
No affinity for choline or adrenaline receptors.
The antidepressant effect is similar to tricyclics, but the tolerability is better than tricyclics.
In animal experiments, it can increase the spontaneous activity of pyramidal cells in the hippocampus and accelerate the recovery of their functions after being inhibited; it can increase the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus.
Tianeptin sodium is absorbed quickly and completely in the digestive tract.
The distribution is rapid, and the PPB is as high as 94%.
It is completely metabolized in the liver through β-oxidation and N-Chemicalbook demethylation, and the clearing terminal T1/2 is short, which is 2.5 hours. A very small amount of the original drug (8%) is excreted from the kidney, mainly due to its metabolites in the urine.
excretion.
In patients with renal insufficiency, the clearance of T1/2 was prolonged by 1 hour.
Indications
It is used to treat mild, moderate or severe depression, neurogenic and reactive depression, physical anxiety and depression, especially gastrointestinal discomfort, and anxiety and depression in patients with alcohol dependence during withdrawal.
The recommended dose is 12.5 mg tid orally before the main meal in the morning, middle and evening.
Patients with chronic alcoholism, regardless of whether they have liver cirrhosis, do not need to adjust the dose.
For patients over 70 years of age and renal insufficiency, the dose is limited to 2 tablets per day.
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