Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.364782-34-3
Pharmaceutical grade(1-5)KilogramPharmaceutical grade(6-99)Kilogram
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| Molecular Formula | C22H23ClF3N |
| Molar Mass | 393.88 |
| Melting Point | 175-177°C |
| Solubility | Soluble in water (1 mg/ml at 25 °C), DMSO (79 mg/ml at 25 °C), ethanol (33 mg/ml |
| Storage Condition | Inert atmosphere,2-8°C |
| Use | An allosteric activator of CaSR |
| In vitro study | Cinacalcet HCl represents a new class of compounds used to treat hyperthyroidism, is a calcimimetic, by increasing the parathyroid calcium-sensing receptor (CaR) it is sensitive to extracellular calcium ions and reduces the synthesis and secretion of parathyroid hormone (PTH). Cinacalcet HCl has a potential advantage as a therapeutic agent for secondary hyperparathyroidism because it mimics the action of extracellular calcium ions to inhibit PTH secretion, even in the presence of hyperphosphatemia, there is also no risk of causing hypercalcemia and/or hyperphosphatemia. Cinacalcet HCl produces a concentration-dependent increase in cytoplasmic calcium in CaSR-expressing human embryonic kidney cells. In bovine parathyroid cells and a buffer containing calcium 0.5 mM,AMG 073 (3 nM - 1 μm) produced a concentration-dependent decrease in PTH levels with an IC50 of 27 nM. |
| In vivo study | Cinacalcet HCl was administered orally to normal rats at doses of 1, 3, 10, and 30 mg/kg in 20% sodium sulfobutyl ether β-cyclodextrin, after 1 to 4 hours of administration, there was a significant dose-dependent reduction in PTH levels. At 8 hours, compared with the control group, cinacalcet HCl at doses of 10 and 30 mg/kg produced a significant reduction in PTH levels, which disappeared at 24 h. After oral administration of Cinacalcet HCl at doses of 3, 10, and 30 mg/kg, significant reductions in serum calcium levels were observed after 4, 8, and 24 hours, respectively. A transient decrease in serum phosphorus levels was observed only at high doses of Cinacalcet HCl. In addition, in rats, at 40 mg/kg Cinacalcet HCl, with the inhibition of PTH, an increase in the level of calcitonin can be observed. In normal rats, a rapid dose-dependent decrease in PTH and calcium levels was able to be observed in 5 of 6 nephrectomized rats after oral administration of Cinacalcet HCl. In addition, oral administration of 5 and 10 mg/kg Cinacalcet HCl for 4 weeks significantly reduced the weight of parathyroid glands compared with the control group. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
6. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
7. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
8. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
9. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
10. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.