Hebei Nengqian Chemical Import and Export Co., LTD
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
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Ms.AnnaCAS NO.37339-90-5
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
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Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
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Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| source | lentinan is a kind of high molecular glucan with anti-cancer effect extracted from lentinan entity. its polysaccharide part is mainly mannose, and there are glucose, galactose, xylose, arabinose, etc. the peptide chain is composed of 18 kinds of amino acids such as aspartic acid, histidine, serine and glutamic acid. [Source Plant] Lentinus edodes is the fruiting body of the fungus Lentinus edodes of the genus Lentinus edodes. Lentinus edodes is rich in nutrition. Every 100 grams of dried product contains 13 grams of protein, 1.8 grams of fat, 54 grams of carbohydrates, 7.8 grams of crude fiber, and a variety of vitamins. It contains more vitamin D and adenine, which has a preventive effect on the occurrence of rickets and liver cirrhosis. Lentinus edodes contains lentinan, which can inhibit the proliferation of sarcoma S-180 in mice and has certain prospects in the development of natural anticancer drugs. The artificial cultivation of shiitake mushrooms began in China. Wang Zhen's "Nongshu" in Yuan Dynasty recorded the cultivation method of shiitake mushrooms in detail. This natural spore inoculation and cultivation method has been used in China, Japan and other countries until modern times. In 1928, Japan Morimoto Hikaburo successfully cultured pure mushrooms with isolation medium. Later, Japan gradually promoted the artificial inoculation and cultivation of pure strains. This technology was introduced to China in the 1930s and began to be widely used in the mid-1960s. During the same period, Shanghai Edible Fungus Research Institute and other units tried sawdust to cultivate shiitake mushrooms, which was gradually popularized and applied in the 1970s, making substitute cultivation a cultivation method with Chinese characteristics. Shiitake mushrooms rank second in the world's total mushroom production. Japan has the largest output of shiitake mushrooms. In 1987, China's output of dried shiitake mushrooms exceeded 10,000 tons, ranking second in the world. [morphology] the cap is semi-fleshy, 5~12cm in diameter, oblate hemispherical, gradually spreading back, yellowish brown to dark cinnamon, with scales on it. The flesh is thick, white, and the gills are white, dense and curved. From native to partial, white, internal solid, often curved, 3~5cm long, 0.5~0.8cm in diameter, the part below the fungus ring is often covered with scales. The fungus ring is narrow and easy to disappear (Figure 1). The spores are colorless and smooth. Oval, 5 × 2.5 microns. Figure 1 shows shiitake mushrooms. |
| Polysaccharides | Any sugar that can be hydrolyzed into multiple monosaccharide molecules or their derivatives is a polysaccharide. It is a macromolecular compound formed by condensation and dehydration of 20 monosaccharides to tens of thousands of monosaccharides. Polysaccharides can be condensed from a monosaccharide, such as starch, cellulose, etc. to become homopolysaccharides; they can also be condensed from different monosaccharides or their derivatives, such as hemicellulose, which is called heteropolysaccharides. Plants, animals and microorganisms in nature all contain polysaccharides. In addition to the free state, polysaccharides can also exist in a bound form with proteins. The commonality of plant polysaccharides is that they have natural properties, health care value and unique water-soluble colloid properties, so they can give food high nutritional value, stable and palatable tissue structure, exquisite appearance and unique taste, and extend shelf life. Health function activity of polysaccharide: 1. Anti-tumor. For example, lentinan obtained from Lentinus edodes has strong anti-tumor activity. 2. Enhance immune function. Different polysaccharides have different immune promoting effects. Lentinan is an ideal immune promoter. Tremella polysaccharide can promote the transformation of lymphocytes, enhance the phagocytic function of mouse peritoneal macrophages, significantly promote the synthesis of liver protein and nucleic acid, promote bone marrow hematopoietic function, and improve humoral immunity. Auricularia auricula polysaccharide can effectively improve the phagocytic index and percentage of mouse macrophages. Polysaccharides extracted from garlic and radish have different enhancing effects on T lymphocytes, B lymphocytes and macrophages respectively, which can enhance the cellular immune function of the body. 3. Lowering blood sugar and blood lipid. The polysaccharide with hypoglycemic effect is milk glucan. Lentinan has the effect of dissolving cholesterol. Auricularia auricula polysaccharide has the effect of relieving atherosclerosis. |
| research history | In 1969, Japan's Chihara Kuro first used hot water to extract 6 kinds of extracellular polysaccharides from the fruiting body of Lentinus edodes, of which 2 have obvious anti-tumor activity, with an average relative molecular mass of 1000000, belonging to branched β(1 → 3) glucan. in 1970, Chihard and others extracted 4 kinds of polysaccharides from shiitake mushrooms by hot water extraction and organic solvent precipitation, of which 2 kinds of polysaccharides have anti-tumor effect. in the early 70s, Shida et al. extracted three water-soluble polysaccharides from Lentinus edodes by trichloroacetic acid extraction, methanol precipitation and other methods, one of which was composed of Gal,L-Fuc and Man (molar ratio 6:1.5:1). this is another anti-tumor substance reported for the first time in Lentinus edodes except β-glucan. Sasaki also reported that besides the macromolecule lentinan with a relative molecular mass of 1 million, another small molecule lentinan with a relative molecular mass of 16000 also has anti-tumor activity. Since the 1980s, the research on lentinan has been more in-depth. For example, Schulty extract an intracellular polysaccharide from the hyphae of lentinus edodes, the relative molecular mass (6.0~9.5)× 104 is mannoside containing α-chain, accompanied by a small amount of peptide immunoactive substances composed of serine, threonine and alanine. In 1980, Cotoneaster II in Japan confirmed that lentinan was a broad-spectrum immune promoter. A large number of subsequent studies have shown that lentinan has anti-tumor effects, especially for chronic myeloid leukemia, gastric cancer, nasopharyngeal cancer, rectal cancer and breast cancer. It has the effect of inhibiting and preventing postoperative micrometastasis. This effect is through Enhancing the body's immunity and showing indirect toxicity to cancer cells, so it is especially suitable for the rehabilitation of patients. In 1984, a patent report in the United States was to culture Lentinus edodes with xylose-rich solid medium. From mycelial culture, an anti-tumor glycoprotein with xylose as the main component can be obtained. |
| Chemical structure | Although there are many reports on the chemical composition and structure of lentinan, only β-glucan has a definite immune activity relationship. The primary structure of lentinan has a main chain of glucopyranan connected by β(1 → 3) bonds. The glucose in the main chain is connected to the side chain through 6-C branches. Generally, there are 2 for every 5 glucose. The fulcrum, the side chain is a glucose low polymer connected by β(1 → 6) and β(1 → 3) bonds. Water-soluble β-glucan has a linear structure without large branches. The physiological activity of dextran with β(1 → 3) bond as the main structure is higher than that of polysaccharide with β(1 → 6) as the main structure, and the coexistence of side chains bound by β(1 → 3) and β(1 → 6) is required for anti-tumor effect. Lentinan has a triple helix three-dimensional structure. When this three-dimensional structure is destroyed by urea and DMSO, the immune activity disappears. Other polysaccharides in Lentinus edodes are composed of glucose, galactose, mannose, L-arabinose and xylose, and there are also α-mannosides derived from the mycelium of submerged fermented Lentinus edodes. In recent years, people have carried out research on chemical modification of lentinan to find more effective polysaccharide substances. For example, 10 μg/mL sulfated lentinan can effectively protect HIV-infected MT-4 cells, and 100 μg/mL can inhibit RT activity and the generation of synaptic cells. Its inhibitory effect on stress transcriptase is higher than that of sulfated dextran. Through 13C-NMR and other measurements, it is proved that the introduction of sulfuric acid base leads to the physical and chemical properties of lentinan and the conformational changes of the main body, resulting in the different immune activity of the derivatives. |
| Drug properties and applications | Lentinan is an immune enhancer and is an anti-tumor auxiliary drug. It has no direct anti-tumor effect, but through the activation of the host's disease prevention mechanism, including activation of cytotoxicity of killing T cells, macrophages, natural killer cells (NK) and antibody-dependent macrophages (ADMC), it also enables the inhibited helper T lymphocytes to restore function and increase the induction of interleukin and interferon in the blood to play a synergistic effect, which can further activate the immune system and have a significant protective effect on the liver. Single use or combined with other anti-tumor drugs can inhibit the proliferation of various animal tumors, especially when combined with tegafur (FT-207), the survival time of patients is significantly longer than that of single use. This product is distributed in the whole body organs after 5 minutes of intravenous injection, mainly distributed in the liver, followed by the spleen, lung, and kidney. Its blood drug concentration decreases rapidly, disappears slowly in liver and spleen, and decreases rapidly in lung and kidney. Mainly excreted from the urine, a small amount from the feces, almost not through the placenta, not into the milk. It is clinically used for adjuvant treatment of malignant tumors, such as inoperable or recurrent gastric cancer, liver cancer, and bladder cancer patients, to relieve clinical symptoms, improve immunity, and correct the imbalance of trace elements. Combined with FT-207 can prolong the survival time of patients. It can also be used for hepatitis B, liver poisoning, liver cirrhosis, etc. |
| extraction method | currently, hot water and dilute alkali solution are mostly used for extraction of lentinan, avoiding being carried out in strong acid and alkali solution, otherwise it is easy to cause glycosidic bond breakage and conformational change in polysaccharide. The commonly used separation and purification methods roughly go through the steps of boiling water extraction, ethanol precipitation, dialysis and column chromatography. Considering that there are other physiologically active ingredients in Lentinus edodes (such as adenine, tyrosine oxidase and vitamin D, etc.), the final product formula and extraction purpose should be clarified when determining the extraction method. Generally, the fruiting body of Lentinus edodes is crushed first, stirred and extracted with 90~100 ℃ water for 3~5h, repeated for 2~3 times, then extracted with 0.5mol/L NaOH solution, and the polysaccharide is preliminarily divided into water soluble and alkali soluble parts. Then remove the mushroom residue, the supernatant is dialyzed or ion exchange to remove small molecular impurities, and the crude product is obtained after precipitation with ethanol or thiamine. In the above extraction process, if the mushroom powder is treated with some compound enzyme preparations in advance, the yield of polysaccharide can be greatly improved. |
| adverse reactions | 1. central nervous system: occasional headache, dizziness and head weight. 2. Gastrointestinal tract: occasional nausea, vomiting and decreased appetite. 3. respiratory system: occasionally feel chest pressure or pharyngeal obstruction. 4. Blood system: occasionally red blood cells, white blood cells and hemoglobin decreased. 5. Skin: occasional rash and erythema. 6. Other: Occasionally fever, sweating, facial flushing and other symptoms, rare shock. |
| applicable food category | infants, children and people allergic to edible fungi are not suitable for eating. |
| approval date | 2014-05-20 |
| Announcement No. | Health and Family Planning Commission No. 10, 2014 |
| announcement title | announcement on approval of 6 new food ingredients such as tagatose |
| precautions | those who are allergic to this product are prohibited. there is no clinical experience in the safety of medication for children, the elderly, pregnant women and lactating women, and should be used with caution. The powder injection of this product should be strongly shaken when dissolved in sterilized water for injection, and then diluted with 5% glucose injection or 0.9% sodium chloride injection to adjust it to isotonic solution, and use it as soon as possible after preparation. |
| use | immune enhancer. For patients with inoperable or recurrent gastric cancer. Combined with chemotherapy drugs for patients with gastrointestinal tumors, it can prolong survival time and prevent leukopenia or serum total protein reduction. It has a certain effect on chronic viral hepatitis B, which can significantly improve the patient's symptoms, make the serum alanine aminotransferase normal or improved, and adjust the patient's immune function. Note: Anaphylactic shock, leukopenia and hemoglobin may occasionally occur. Children and women of pregnant and childbearing age should be used with caution. |
| production method | extracted from mushrooms. 200kg of fresh mushrooms were washed with water, crushed and mixed, and extracted with 1000L boiling water for 8~15h. The resulting suspension is filtered or centrifuged to remove insoluble matter. The aqueous solution is concentrated under reduced pressure to a slight turbidity, and an equal volume of ethanol is added. Filtration or centrifugal separation to collect the precipitate to obtain 320g of components containing lentinan. 50g of the component was suspended in 2L of water and mixed at room temperature to form a uniform viscous brown solution. Then add 20L of water and stir for 1-2h to obtain a clear and uniform solution. Under vigorous stirring, 0.2mol/L CTA-OH aqueous solution (pH 13.2) was added dropwise until pH 7~8 showed flocculent precipitation and a large number of white precipitation appeared at pH 10.5~11.5. 0.2mol/L CTA-OH is added dropwise until no precipitation occurs, and the pH value of the solution is about 12.8. All precipitates were collected by centrifugation and washed with ethanol. It was suspended in 1.2L 20% acetic acid and stirred at 0 ℃ for 5min. The precipitate was collected by filtration, and 1L 50% acetic acid was stirred at 0 ℃ for 3min. The precipitate was collected by centrifugal separation and then dissolved in 2L 6% sodium hydroxide aqueous solution. After centrifugation to remove impurities, add 4L ethanol. Collect the precipitate, wash it twice with ethanol, then wash it once with ether, and dry it in vacuum to obtain powder. The Sevag method was used to unfold with chloroform and 1-butanol, and 3 times the volume of ethanol was added to precipitate it. Collect the precipitate, wash twice with methanol, wash once with ether, and dry in vacuum at room temperature and in the presence of calcium chloride to obtain lentinan. 31g of lentinan can be extracted from 200kg of raw materials. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.