Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.375815-87-5
Pharmaceutical grade(1-5)KilogramPharmaceutical grade(6-99)Kilogram
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| Molecular Formula | C17H19N3O6 |
| Molar Mass | 361.34926 |
| Melting Point | 206-208°C |
| Boling Point | 400.6°C at 760 mmHg |
| Flash Point | 196.1°C |
| Solubility | DMSO: >5mg/mL |
| Vapor Presure | 1.25E-06mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| In vitro study | In the nAChRs-expressing HEK cells, Varenicline is a partial agonist, and the efficacy of alpha3beta4 nAChRs is 45% of the maximum efficacy of nicotine. Varenicline is a potent, partial agonist at the alpha4beta2 receptor with an EC50 of 2.3 mM and an efficacy of 13.4% (relative to acetylcholine). Varenicline has lower efficacy and higher efficacy on the alpha3beta4 receptor, EC50 is 55 mM, the efficacy is 75%. |
| In vivo study | Varenicline stimulates [(3)H]-dopamine release from rat brain slices in vitro with significantly lower efficacy than nicotine (40-60% of nicotine), and increase the release of dopamine from the nucleus accumbens in rats, more effective than nicotine. Varenicline effectively attenuated nicotine-induced dopamine release to the level of effect of Varenicline alone, consistent with a partial agonistic effect. Varenicline reduces nicotine self-administration in rats and has a lower self-administration stop point than nicotine. Varenicline dose-dependently reduced nicotine self-administration and attenuated recovery induced by nicotine and nicotine-binding nicotine pairing cues. Varenicline, a partial agonist of alpha4beta2 nAChRs, reduces nicotine intake and was recently approved to aid smoking cessation. Varenicline selectively reduced ethanol uptake by an effective self-administered drinking regime, but did not affect sucrose uptake, in animals chronically exposed to ethanol for 2 months prior to Varenicline treatment, spontaneous ethanol consumption was also reduced, but water consumption was not affected. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
6. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
7. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
8. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
9. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
10. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.