Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.39236-46-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Molecular Formula | C11H16N8O8 |
| Molar Mass | 388.29 |
| Density | 1.4245 (rough estimate) |
| Melting Point | 141-143℃ |
| Boling Point | 514.04°C (rough estimate) |
| Water Solubility | soluble |
| Solubility | Soluble in water and in glycerol, but insoluble in almostall organic solvents. |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Liquid |
| Color | Clear |
| Merck | 14,4916 |
| pKa | 7.41±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. |
| Sensitive | Sensitive to heat and air |
| Refractive Index | 1.6910 (estimate) |
| MDL | MFCD00221482 |
| Physical and Chemical Properties | White liquidity powder, with hygroscopicity, tasteless or slightly characteristic odor, soluble in water, soluble in propylene glycol and glycerol, difficult to dissolve in ethanol. |
| Use | In the cosmetics industry, is the most widely used in addition to parabens preservatives |
| LogP | 0.9 at 20℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Preservative | Imidazolidinyl urea is a kind of preservative in cosmetics. It has broad-spectrum antibacterial activity and can inhibit Gram-negative and positive bacteria. It has a certain inhibitory effect on yeast and mold. It is mainly used to inhibit the reproduction of microorganisms and can be compatible with various components in cosmetics, the test results show that its antibacterial ability is not affected by surfactants, proteins and other special additives in cosmetics. application: imidazolidinyl urea can be used in cream, shampoo, dew, conditioner and other products, can be used alone, can also be used with nipagin esters, IPBC, etc., to enhance its anti-corrosion effect. The use range of pH value is 3~9, the general addition amount is 0.2 ~ 0.4%, and the maximum allowable addition amount is 0.6%, which can be added in a wide temperature range (<90 ℃). Usually imidazolidinyl urea and nipagin ester or Kesson CG cooperate with cosmetic preservatives. It can be used for cream, milk, shampoo, etc. It is especially suitable for some advanced nutritional cosmetics that are easy to be infected with copper green choriobacteria when the ph value is alkaline. The usual dosage is 0.1% ~ 0.5%. However, because imidazolidinyl urea has a irritating effect on the skin of some people, it is easy to cause allergies. At present, it is no longer used in some high-end cosmetics. |
| use | imidazolidinyl urea is a new generation of cosmetic preservative. it is used in the cosmetic industry and is the most widely used preservative except nipagin ester. it has a wide antibacterial spectrum and can be compatible with almost all cosmetic raw materials. the use concentration is 0.05% ~ 0.5%, and the most suitable pH3 ~ 9. it can be added at any stage of cosmetic manufacturing, combined with nipagin ester shows synergistic effect. In the mid-60s, Germall 115 was first synthesized in the Sutton laboratory, and then Germall II was synthesized in 1981. The antibacterial effect is better than that of Germall 115. It is particularly effective against Pseudomonas, bacteria, molds, and yeasts. It is also effective. It is widely used in cream, lotion, shampoo and some cosmetics that are difficult to preserve. It can also be used as a preservative for food and medicine. Used for biological research on the antibacterial synergistic activity of essential oils and surfactants for Pseudomonas aeruginosa and Staphylococcus aureus; used to shift energy metabolism from mitochondrial respiration to glycolysis, nutrient activation, Pharmacological research of drug shielding effect; used for local delivery of active molecules, including plant-based nanostructured carriers; used as a local prescription for antioxidants; used in preventive analysis and research, A comparative study of MEKC and microemulsion electrokinetic chromatography; the study of apoptosis and necrosis induced in vitro due to the widely used prevention method. |
| production method | imidazolidinyl urea is generally composed of alkyl imidazole derivatives such as allantoin (allantoin) and formaldehyde in alkaline medium reaction, control different process conditions to obtain Germall 115 or Germall II. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.