Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.4292-19-7
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C10H12ClN5O3 |
| Molar Mass | 285.69 |
| Density | 2.03±0.1 g/cm3(Predicted) |
| Melting Point | 181-185°C(lit.) |
| Boling Point | 547.6±60.0 °C(Predicted) |
| Specific Rotation(α) | D25 -18.8° (c = 1 in DMF) |
| Solubility | Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9). |
| Appearance | White solid |
| Color | White to Pale Yellow |
| Maximum wavelength(λmax) | ['265nm(EtOH aq.)(lit.)'] |
| Merck | 14,2337 |
| pKa | 13.75±0.60(Predicted) |
| Storage Condition | -20°C |
| Stability | Store in Freezer |
| Sensitive | Sensitive to heat |
| Physical and Chemical Properties | Crystallized from water, softened at 210-215 °c, and turned brown after curing; Crystallized from ethanol, melting point 22023 (softening), solidified, turned brown, and no longer melted at <300 °c. [Α] D23-18.8 °(C = 1, dimethylformamide). UV maximum absorption (0.1mol/L sodium hydroxide):265nm:(0.1mol/L hydrochloric acid):265nm. |
| Use | It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation I |
| In vitro study | Cladribine exerts marked activity against hairy cell leukemia (HCL), a chronic B- cell lymphoproliferative disease, prolonging complete remission. Cladribine induces the accumulation of DNA strand breaks and subsequently activates the tumor suppressor gene p53 in lymphocytes. Cladribine may regulate STAT3 activity in MM cells. Cladribine dose-dependently inhibited proliferation/survival of U266,RPMI8226 and MM1.S cells. Among them, U266 had the lowest sensitivity to cladribine and the highest sensitivity to MM1.S. Cladribine treatment gradually increased the proportion of cells in the G1 phase of the cell cycle and decreased S-phase cells. Cladribine treatment after 24 hours appears to be able to increase the proportion of G2-M phase in U266 cells. A dose-dependent increase in cladribine-induced apoptosis was observed in both RPMI8226 and MM1.S cells. 0.2 μm cladribine treatment time-dependently significantly induced caspase-3,-8, and -9 activation and PARP cleavage in MM1.S. Cladribine significantly reduced phospho-STAT3 (P-STAT3) levels in a dose-dependent manner, but did not affect total STAT3 protein levels. Cladribine has the potential to induce apoptosis in a concentration-dependent manner in HSB2 cells. Cladribine inhibited the growth of primary mast cells (MC) and MC lineage HMC-1 in a dose-dependent manner, HMC-1.2 cells containing KIT D816V compared to HMC-1.1 cells lacking KIT D816V, has a lower IC50 value. Cladribine reduced CD14 |
| In vivo study | Cladribine (0.7-3.5 mM) and/or diltiazem (2.4 mM), injected intraperitoneally into adult zebrafish, analyzed by HPLC for potential markers of cardiovascular health, red blood cells (RBC) lysate levels of purine nucleotides (e. G., ATP). Diltiazem increased RBC ATP concentrations, an effect that was inhibited by coinjection of cladribine. After administration of Ia and s.c., Cladribine plasma concentrations sharply decreased with a biphasic decline. After a single dose of Cladribine injected at 1 mg/kg ia and 2 mg/kg s.c., the AUD and t 1/2β were 0.66: 1.2 μg × h/mL and 3.5: 4.5 h, respectively. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.