Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.434-13-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molar Mass | 376.57 |
| Density | 1.0454 (rough estimate) |
| Melting Point | 183-188 °C (lit.) |
| Boling Point | 445.09°C (rough estimate) |
| Specific Rotation(α) | D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer) |
| Flash Point | 9℃ |
| Water Solubility | 18.83ug/L(25 ºC) |
| Solubility | Easily soluble in hot alcohol, slightly soluble in glacial acetic acid, insoluble in petroleum ether, gasoline, water |
| Vapor Presure | 1.4E-12mmHg at 25°C |
| Appearance | prismatic crystallization |
| Color | White to off-white |
| Merck | 5545 |
| BRN | 3217757 |
| pKa | 4.76±0.10(Predicted) |
| Storage Condition | room temp |
| Refractive Index | 35.5 ° (C=1, EtOH) |
| MDL | MFCD00003682 |
| In vitro study | Lithocholic acid (LCA) is a hydrophobic secondary bile acid formed by the 7α-dehydroxylation of the bacterium chenocholic acid in the intestine. LCA causes intrahepatic cholestasis (termination or obstruction of bile flow). LCA activates PXR (pregnane X receptor), and LCA-induced severe liver injury can be protected by PXR activation. LCA is a ligand for the farnesol X receptor (FXR) with an EC50 of 3.8 μm. LCA binds directly to VDR (vitamin D receptor),K I is 29 μm, and activates VDR (vitamin D receptor),K I is 30 μm, compared with other nuclear receptors (e. G. PXR,FXR) it has a higher sensitivity, and its toxic effects are therefore suppressed. LCA has tumor-promoting activity and inhibits mammalian DNA polymerase β with an IC50 of 15 μm. |
| In vivo study | Binding with rodents after administration of LCA causes intrahepatic cholestasis, a pathological condition characterized by a decrease in bile flow and accumulation of bile components in the liver and blood. In a DMH (dimethylhydrazine)-induced mouse model of carcinogenesis, LCA almost completely inhibited apoptosis in the precancerous colon. LCA activates VDR, inducing in vivo expression of CYP3A, a cytochrome P450 enzyme that detoxizes LCA in the liver and intestine. |
| Overview | Lithocholic acid is a secondary bile acid, also known as cholic acid, 3 A- hydroxycholanic acid, lithocholic acid, 3 A- alkanic acid, lithic acid, 3-hydroxycholenic acid, lithic acid, exist in the bile of higher vertebrates. Its molecular structure contains both hydrophilic groups and hydrophobic groups, so the three-dimensional configuration of bile acids has two properties: hydrophilic and hydrophobic, so bile acids have strong interfacial activity. After consulting the literature, it is found that lithocholic acid has more pharmacological activities, such as: inhibiting tumor growth, selectively killing breast cancer cells, and selectively inhibiting the activity of mammalian DNA polymerase. |
| Classification | Bile acids are structurally divided into two categories: one is free bile acids, including cholic acid, Deoxycholic acid (deoxycholic acid), chenodeoxycholic acid, and lithocholic acid; the other is conjugated bile acid, it is formed by the combination of the above free bile acids with glycine or taurine, mainly including glycocholic acid, glycochenodeoxycholate acid, taurocholic acid and taurochenodeoxycholate acid. |
| pharmacological action | lithocholic acid can kill glioma cells and is harmless to normal nerve cells. the specific principle of action: low concentration of lithocholic acid (LCA) can make BE(2)-m17 and SK-n-MCIXC cells sensitive to hydrogen peroxide-induced cell decline, A certain concentration of LCA makes the original culture of human neuron cells have a certain ability to resist this type of cell death. LCA can kill BE(2)-m17 and SK-n-MCIXC cells not only through the path of internal decay cell death driven by triggering the permeabilization of the outer mitochondrial membrane and the activation of the initiator CASPASE-9, but also through the external path of cell decay involving the CASPASE-8 activation of the initiator. These intrinsic and extrinsic pathways of tumor cell decay can be interpreted by the apoptotic cascade. |
| biological activity | Lithocholic acid is a bile acid that can dissolve fat for absorption. |
| Target | Value |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.