Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.474-07-7
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C16H14O5 |
| Molar Mass | 286.28 |
| Density | 1.1924 (rough estimate) |
| Melting Point | 156-157°C |
| Boling Point | 555.8°C at 760 mmHg |
| Solubility | Soluble in ethanol and ether, soluble in water. |
| Appearance | Pale crystal |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00210817 |
| Physical and Chemical Properties | The chemical properties are derived from the genus hematoxylin. |
| Use | Uses for content determination/identification/pharmacological experiments. Pharmacological Efficacy: Antioxidant Activity |
Overview
hematoxylin is a leguminous cloud plant, hematoxylin (fp was applied with s dipstick p nL. Dry heartwood, with blood stasis, swelling and pain, commonly used in the treatment of traumatic injury, fracture of tendons, blood stasis, swelling and pain, amenorrhea, postpartum blood stasis, chest and abdominal pain, swelling and pain of anthrax. Brazil hematoxylin (Brazi.1in), also known as the threonine, Brazil red lignin, Su Mu cryptochrome, is the main active ingredient of hematoxylin, at the same time as a natural pigment commonly used in pathological tissue staining. Brazilian hematoxylin belongs to the high isoflavone derivatives (structure see figure 1), molecular formula C,. H,. O, with antibacterial, anti-inflammatory, hypoglycemic, immune regulation and other pharmacological activities. In addition, Brazil hematoxylin is an important basis for the evaluation of the quality of hematoxylin medicinal materials, 2010 edition of the "Chinese Pharmacopoeia" provides that the content of the compound in hematoxylin medicinal materials shall not be less than 0.5%[1].
physical data
character: Amber yellow crystal. Turn orange in air and light. Above 130 degrees C decomposition.
solubility: soluble in ethanol and ether, soluble in water, aqueous solution is colorless, in the air to red. Dissolved in alkaline solution in red, and oxidized to colored Brazilian annatto.
extraction
The extraction and separation methods of Brazilian hematoxylin reported in the literature and patent reports are similar, and the crude extract is usually extracted by heating and refluxing with aqueous ethanol or methanol, and the solvent is recovered to obtain the crude extract, then it was extracted with solvent of different polarity such as petroleum ether, ethyl acetate and n-butanol successively. For ethyl acetate extract, combined with a variety of column chromatography (such as silica gel column chromatography, dextran gel column chromatography, polyamide column chromatography and macroporous resin column chromatography, etc.), brazilian hematoxylin & uml; "J can be obtained. Because the traditional column chromatographic separation technology has the disadvantages of long time and large solvent consumption, the high isoflavone compounds in hematoxylin were prepared by high speed Countercurrent Chromatography (HSCCC) for the first time, with chloroform methanol water (4:3:2,v/v/v) as the two-phase solvent system, the upper phase as the stationary phase, the lower phase as the mobile phase, under the conditions of a flow rate of 1.0M L/quotient n, a rotation speed of 900rpm, a detection wavelength of 280nm and a temperature of 25 ℃, 18mg of Brazilian hematoxylin was isolated from 120mg of the crude extract in one step, the purity and average recovery were both 85%.
pharmacological activity
1. Antibacterial effect
as an antibacterial active ingredient, hematoxylin against some antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and multi-drug resistant Burkholderia cepacia and other bacteria have significant inhibitory effect, the minimum inhibitory concentration of 4~32g/m L[2]. Batub hoes et al in the study of 28 kinds of plant anti-acne efficacy, found that hematoxylin methanol extract and 50% ethanol extract on the growth of Propionibacterium acnes has obvious inhibitory effect, the methanol extract was further separated to obtain the Brazilian hematoxylin, the original hematoxylin A and hematoxylin B. The activity screening results showed that the Brazilian hematoxylin had stronger antibacterial activity than the original hematoxylin A and hematoxylin B, the minimum inhibitory concentration was 0.5mg/ml.
2. Hypoglycemic effect
von et al. H71 investigated the effect of Brazilian hematoxylin on the glycogen neogenesis and ketogenesis in rat hepatocytes. It was found that Brazilian hematoxylin may reduce the ability of glycogen neogenesis in rat hepatocytes, so as to achieve the purpose of reducing blood sugar. Khil et al. investigated the key molecular structure of Brazilian hematoxylin promoting glucose transport in adipocytes. The results showed that the peroxide produced by the oxidation of Catechol hydroxyl in Brazilian hematoxylin regulates sugar transport by inhibiting phosphatase. In addition, the study found that the Brazilian hematoxylin can inhibit the insulin signaling pathway related to protein kinase C and insulin receptor serine enzyme, indicating that the Brazilian hematoxylin may increase the function of insulin receptor by reducing the phosphorylation of serine, thereby reducing blood glucose concentration [3].
synthesis
In recent years, the total synthesis route of Brazilian hematoxylin has been studied, through special chemical transformation methods, such as the use of IBx to oxidize phenol to O-quinone, further isomerization, the racemate of Brazilian hematoxylin was obtained by intramolecular cyclization and other methods
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.