Hebei Nengqian Chemical Import and Export Co., LTD
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- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.477-43-0
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C15H18O2 |
| Molar Mass | 230.3 |
| Density | 1.09 |
| Melting Point | 57.0 to 61.0 °C |
| Boling Point | 140-143 °C(Press: 0.5 Torr) |
| Specific Rotation(α) | [α]/D -14.0±3.0°, c = 1 in chloroform |
| Flash Point | 161.2°C |
| Solubility | Soluble in ethyl acetate, acetone, DMSO and other solvents, insoluble in water. |
| Vapor Presure | 4.31E-06mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['206nm(MeOH)(lit.)'] |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.536 |
| MDL | MFCD00210277 |
| Physical and Chemical Properties | Soluble in ethyl acetate, acetone, DMSO and other solvents, insoluble in water. Derived from a plant belonging to the genus aucklandia of Compositae [Vladimiria souliei(Franch. )Ling] |
| costustum extract | deshydro-costustolide is a substance extracted from the roots of costustum, a plant of the genus Costustum of the Compositae family, which has relaxing smooth muscle and antispasmodic effects. The main components of costustaceae contain volatile oil and inulin. The volatile oil contains dehydro-wood lactone, etc. |
| Source plant | The main source is the root of the genus Asteraceae. [plant morphology] perennial herb with thick main root, up to 5cm in diameter. Stem erect, 1.5~2m high, unbranched, pubescent upper part. The basal leaves have long stalks with wing and pinnate lobes, and the leaves are very large and triangular; the base of the stems and leaves are wedge-shaped and extended into winged petioles or sessile, and the leaves are ovate or triangular-ovate, 30 ~ 50cm long and 10 ~ 30cm wide, with irregular serrations on the edges, short thorns on the tooth ends, short rough hairs on the surface, glabrous on the back or sparse short hairs on the veins. Head inflorescences solitary stem top or leaf axils, or 2~3 bundles, 3~4cm in diameter; involucre hemispherical, 2~2.5cm long, involucral bracts 7 layers, nearly leathery, ovate-lanceolate or narrowly lanceolate, glabrous or sparsely hairy; Trichose; Corolla tubular, about 15mm long, dark purple; Anther tail fasselate. Achenes oblong, ribbed; crest 2-layered, pale brown, feathery, outer layer shorter. The flower and fruit period is from May to October. [habitat distribution] should be planted in high mountain areas with an altitude of 2500~4000m, and cool plains and hills can also be planted. Native to India. China Shaanxi, Gansu, Hubei, Hunan, Guangdong, Guangxi, Sichuan, Yunnan, and Tibet are all cultivated. Figure 1 is the wood incense |
| extraction method | 1, solvent extraction method Xu Hui and others used orthogonal experimental method to investigate the various influencing factors of ethanol extraction of essential oil from wood, and analyzed the data through multi-index comprehensive score. Results The best extraction process was as follows: adding 8 times the volume fraction of 60% ethanol, heating and reflux extraction for 2 times, each extraction for 1h. This extraction process can effectively control the production process and fundamentally ensure the quality of the product. Hou Shuzhen et al. obtained the results on the basis of their experiments: the yield of volatile oil in the soup was the highest after soaking and decocting for about 20min. With the extension of decocting time, the content of volatile oil in the soup decreased, but it was not significant. The amount of extract decocted increases with the extension of decocting time. 2. Steam distillation After pulverizing the wood, use the volatile oil extractor to extract the volatile oil according to the "Chinese Pharmacopoeia" volatile oil determination method. The volatile oil is obtained after drying with anhydrous sodium sulfate, and the yield is 1.5%. The volatile oil is a pale yellow transparent oily liquid with a special strong fragrance. 3. carbon dioxide supercritical extraction method 20g of cotyledon was crushed and added into a 50mL supercritical CO2 extraction tank. The pressure is 15MPa, the temperature of the extraction tank is 50 ℃, and the temperature of the receiving tank is 30 ℃. Dynamic extraction for 50min to obtain yellow transparent oil with strong fragrance and oil yield of 2.4%. 4. Microwave irradiation-extraction method Hui Ruihua et al. used microwave irradiation-extraction method to extract the volatile substances of Radix Cotlewood. The content of the volatile oil of Radix Cotlewood was measured to be 4.5%. The gas chromatography-mass spectrometry (GCMS) method was used to separate and confirm 48 kinds of chemical components, accounting for more than 93.3% of the total volatile oil. The relative percentage content of each chemical component in volatile oil was obtained by using the peak area normalization method through the chemical workstation data processing system. The method is stable, reliable and reproducible. It is suitable for chemical composition analysis of volatile oil from traditional Chinese medicine. The wavelength of microwave is about 100~0.1cm, I .e. the frequency is 300~300GHz. Usually the frequency used for microwave extraction and chemical reactions is about 915MHz or 2450MHz, which is also called ultra-high electromagnetic wave. |
| pharmacological action | 1. effect on digestive system: costustine 25% decoction (0.25g crude drug/mL) was given to rats at 10 mL/kg. as a result, the relative residual rate of pigment in the stomach of rats was significantly reduced and the propulsion ratio of small intestine was significantly increased, indicating that costustine can promote gastric emptying and intestinal propulsion. 10, 40g/kg of Muxiang decoction was injected into dogs with Hay's small stomach through the mouth. The results had no effect on gastric acid and serum gastrin concentration, but could promote the secretion of somatostatin. Muxiang can accelerate the emptying of barium by the stomach and promote the release of endogenous motilin. It has no effect on the basic gastric electrical rhythm of normal people. 2. The effect on the cardiovascular system: The wood and its extracts have a pressor effect, while the alkaloids, lactones, and lactone volatile oils contained in it have a hypotensive effect. Muxiang excites the cat heart with mild pressor response. Intravenous injection of water extract into anesthetized dogs has mild pressor effect. Intravenous injection of delactone volatile oil, total lactone, costule lactone, dihydrogen costule lactone, dehydro costule lactone or 12-methoxydihydrocostule lactone can reduce blood pressure in anesthetized dogs, and the antihypertensive effect lasts for at least 15min, and the effective time of delactone volatile oil can reach 1h. 12-methoxydihydrocoletholide has a strong effect. Neck spinal cord cut, vagus nerve cut on both sides, atropinization, ganglion blockers, antiepinephrine or antihistamines do not change the above antihypertensive response, indicating that its site of action is mainly peripheral, that is, It is related to cardiac inhibition and vasodilation. 3. Effect on the respiratory system: Using guinea pig isolated trachea and lung perfusion experiments, it shows that water extract, alcohol extract, volatile oil, total alkaloids, and total lactones contained in volatile oil The volatile oil has a antagonistic effect on the bronchoconstriction caused by histamine, acetylcholine and barium chloride. Intraperitoneal injection of total lactone or lactone volatile oil has a protective effect on inhaled lethal dose of histamine or acetylcholine aerosol in guinea pigs, which can prolong the incubation period of asthma and reduce mortality, indicating that it can directly expand bronchial smooth muscle, which is similar to papaverine. 4. Antibacterial effect: The concentration of volatile oil of 1 ∶ 3000 can inhibit the growth of Streptococcus, Staphylococcus aureus and Staphylococcus albicans, and has weak effect on Escherichia coli and Diphtheria; total alkaloids have no antibacterial effect. |
| identification | identification of wood fragrance cylindrical or semi-cylindrical, 5~10cm long and 5~50mm in diameter; The surface is yellowish brown to gray brown, most of the cork has been removed, with obvious longitudinal grooves and lateral root marks, and sometimes reticular wrinkles can be seen. The quality is hard, not easy to break, the section is not neat or slightly flat, the periphery and the center are grayish yellow, most of the rest are grayish brown to tan, the dark brown oil chamber dots are scattered everywhere, the formation layer is ring brown, with radial texture, and the center of the old root is more decayed. The aroma is rich and specific, and the taste is slightly bitter. The color is yellow and white, the quality is solid, and the aroma is strong. Microscopic identification of root cross section: the cork layer is 2~6 rows of cork cells. The phloem is broad and the sieve tube group is obvious; the phloem fibers are several to a dozen bundles. The cambium intermittently forms a ring. The xylem catheter bundle is radially bifurcated, and the catheter 2 exists in multiple groups or individually; the wood fiber is small, and the catheter is adjacent to each other; the near-center wood fiber bundle is arranged in 3~4 rings. This product is scattered with most large split oil chambers, oval or round in shape, 29~254 μm in diameter, 6~11 secreting cells around, containing volatile oil droplets; Parenchyma cells are full of inulin. Powder: brown, with a strong aroma, slightly sweet taste, bitter after. (1) The powder is observed with a Si's liquid device, and colorless and irregular inulin clumps can be seen; with chloral hydrate liquid device (not heated), inulin is fan-shaped, with radial lines, and it gradually melts after long-term storage. (2) The wood fiber is mostly bundled, long fusiform, oblique or fine tip at the end, 16~24 μm in diameter, 4~5 μm in wall thickness, fine holes, transverse cracks or herringbone or cross-shaped. (3) the reticulated catheter has a rim hole and a ladder tube diameter of 32~90 μ m, and the catheter molecules are generally very short, some are only 64 μ m long; The reticulated holes are slit-shaped and dense. ④ Light yellow fragments can sometimes be seen in the oil chamber, containing volatile oil droplets. ⑤ Some parenchyma cells contain small calcium oxalate square crystals or volatile oil droplets. Physical and chemical identification: 100g of sample powder is taken, volatile oil is extracted in a volatile oil extractor, 0.1ml of volatile oil is added with 1ml of petroleum ether to dissolve, and is placed on a silica gel G-CMCNa-fluorescein (5g:0.5% 15ml:1mg) plate, petroleum ether (30-60C)-ethyl acetate-benzene (14:3:3) is used as developing agent, and isomethylenolide is used as control. The spreading distance is 18cm, and the lactone spots are all blue fluorescent under the ultraviolet light lamp (254nm), and the color is developed with 5% vanillin-concentrated sulfuric acid, with 5 spots. |
| character characteristics | 1. medicinal materials: cylindrical or semi-cylindrical, slightly curved, slightly twisted, slightly similar to chicken leg bone, 5~25cm long and 0.5~1.5cm in diameter. The surface is yellowish brown or dark brown, with longitudinal wrinkles or longitudinal grooves, and protruding lateral root marks or occasionally branched at the lower part. The quality is hard, easy to break, the cross section is slightly flat, yellowish brown, and there is an obvious brown ring, brown oil spots can be seen on the skin, and the wood is often biased to one side, showing chrysanthemum heart. The air is special, the taste is slightly bitter, slightly pungent, and the sticky teeth are chewed. 2. processed products: yuexi wood fragrance slices: round-like flakes with a diameter of 0.5~1.5cm and a thickness of 1.5~3mm. the cut surface is yellowish brown or yellowish brown, with an obvious brown ring. brown oil spots can be seen on the skin part, and the wood part is often biased to one side, showing chrysanthemum heart. The periphery is yellowish brown, dark brown or grayish brown, with longitudinal wrinkles. The air is special, the taste is slightly bitter, pungent, and the sticky teeth are chewed. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has a strong choleretic effect, and has a good antispasmodic effect on bronchial smooth muscle and small intestinal smooth muscle. The antispasmodic effect is muscular, similar to papaverine and weaker. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.