Hebei Nengqian Chemical Import and Export Co., LTD
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18233902561
Mobile: +86 18233902561
Tel: +86 18233902561
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.479-98-1
medical grade(1-50)Metric Tonmedical grade(50-500)Metric Ton
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Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
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Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
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| Molecular Formula | C15H22O9 |
| Molar Mass | 346.33 |
| Density | 1.61±0.1 g/cm3(Predicted) |
| Melting Point | 181° |
| Boling Point | 669.0±55.0 °C(Predicted) |
| Specific Rotation(α) | D21 -163.1° (c = 1.6) |
| Flash Point | 358.414°C |
| Solubility | Soluble in water, ethanol and methanol, almost insoluble in chloroform, ether and petroleum ether. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White needle crystal (ethanol) |
| BRN | 50340 |
| pKa | 12.80±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.66 |
| MDL | MFCD00136026 |
| Physical and Chemical Properties | Soluble in water, ethanol and methanol, almost insoluble in chloroform, ether and petroleum ether. From eucommia ulmoides, plantain, Rehmannia and other Chinese herbal medicines. |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| Reference
Show more |
1. Xu Dodo, Peng Huanhuan, Jiang Meifang, etc. LC-LTQ-Orbitrap analysis of chemical constituents of extract from radix s... |
| Plant source: | Eucommia |
| overview | aucubin (Aucubin), also known as coral glycoside, chemical name β-D-glucopyranoside, bitter, soluble in water, ethanol, methanol, insoluble in chloroform, ether, petroleum ether and other solvents. This product is a kind of iridoid compound widely existing in many plant species in nature. It has the ability to clear dampness and heat, relieve urine, relieve pain, reduce blood pressure, protect liver and protect liver, anti-inflammatory, anti-tumor and other biological actives. It can promote stem cell regeneration and obviously inhibit the replication of hepatitis B virus DNA. Its aglycone and effective polymer are antibiotics. Since the discovery of the existence of aucubin in natural plant species, it has been successively found in plant species such as Garryaceae, Scrophulariaceae (Scrophulariaceae), Scrophulariaceae (Scrophulariaceae), Globulariaceae, Eucommiaceae (Eucommiaceae), etc. This compound has been found in the genus, and the content of planago and Eucommia is very high. The main source of aucubin is extracted from natural plants, and some people use tissue culture to extract aucubin from eucommia ulmoides callus. Fig. 1 is the structural formula of aucubin |
| Distribution and biosynthesis | Distribution of aucubin in plants mainly exists in Loniceraceae, Pteranaceae, and Eucommia plants. Traditional Chinese medicines containing aucubin include Eucommia, plantain, Rehmannia, Vitex, Scrophulariae, Taibaishen, etc. Among them, Eucommia leaves, skins, and seeds all contain aucubin, while the whole plant contains aucubin, and the rest contain aucubin in the roots. Taoleucoside not only exists in Chinese herbal medicine, but also in some flowers and fruits. Such as native to China's Taiwan and Japan, aucubin is an excellent indoor foliage plant, its chemical composition contains aucubin. The flowers, stems and leaves of jasmine contain iridoids, and aucubin is one of them. In addition, the third generation green fruit Lonicera edulis, which has the reputation of "fruit nutrition bank", also contains aucubin. Biosynthetic aucubin belongs to cyclopentene-type iridoid glycosides. This kind of compound is hydrolyzed from pyrophosphate to remove pyrophosphate in plants, and then oxidized to form citral. The latter is cyclized, double bond shift, hydration and oxidation to form Iant dialdehyde. Then, after enolization, Iant dialdehyde undergoes intramolecular condensation to form irene ether terpene alcohol, which then forms irene ether terpene glycosides. The main source of aucubin is extracted from natural plants, and some people use cell engineering methods to culture aucubin from the callus of Eucommia ulmoides. From an economic point of view, since most of the plants that can extract aucubin are cheap and easy to obtain, extracting aucubin from plants has more research and development prospects than other methods. |
| extraction and separation | 1. cold leaching extraction method: since aucubin is easily soluble in methanol, it is extracted with 30% methanol solution. When the room temperature is placed, the color of the solution changes. The higher the room temperature, the faster the change. When the sample is extracted, the sample is placed in the refrigerator overnight. The color of the sample solution remains unchanged, and then placed, there is no change. Therefore, the sample solution is stable after cold leaching with 30% methanol solution. The process is simple and economical, but the extraction time is long. 2. Alcohol extraction of lead salt precipitation method: extract with ethanol, concentrate the extract to prepare extract, then add water to dissolve, then add lead salt to precipitate, filter the precipitate, pass the filtrate into H2S to remove lead, reduce pressure After concentration, dissolve the residue with acetone, concentrate the acetone liquid to obtain a crude aucubin, and finally recrystallize to obtain a pure product. Because the lead precipitation method has a certain selectivity for aucubin, this method can obtain a relatively pure aucubin, but due to the use of toxic heavy metal lead, it may cause certain pollution to aucubin products. 3. Ultrasonic extraction method: Ultrasonic is a uniform spherical mechanical wave, with a unique form of action-cavitation produces a strong shock wave and micro-jet inside the liquid, which can crush the cell wall and make the intracellular components penetrate into the solution In order to achieve the purpose of separation. The ultrasonic extraction method is simple and fast to operate, has the advantages of saving time and no heating. It can be used to extract some substances that are easily destroyed and decomposed by heat, and has low comprehensive cost, low pollution, and easy separation of the extract, which can achieve better than conventional extraction. The method is more ideal. In addition, the method is simple and suitable for industrial production, but it is currently limited to laboratory scale. 4. Macroporous resin adsorption method: Macroporous adsorption resin is a kind of polymer adsorbent with macroporous structure without exchange groups, and it is also a lipophilic substance. It has the advantages of good selectivity, high mechanical strength, convenient regeneration treatment, fast adsorption speed, simple operation, stable product quality, low production cost, etc., so it is especially suitable for separation and purification of water-soluble compounds. However, this method takes a long time and is difficult to clean the adsorption resin. At present, the adsorption resins used to purify aucubin mainly include S-8 resin and D4020 resin. Among them, S-8 resin has good selectivity and large adsorption capacity. It can be completely eluted with 60% ethanol aqueous solution. |
| biological activity | aucubin has a wide range of biological activities, and the research on its biological activity in modern science has gone deep into many fields such as food, health care, medicine and daily chemical industry. 1. Anti-inflammatory and antiviral effects of aucubin has obvious hepatoprotective effects and can significantly inhibit the replication of hepatitis B virus DNA. Studies have shown that aucubin can significantly inhibit the increase of ALT and AST caused by liver injury caused by CCl4 in serum, and can prevent the decline of liver RNA synthesis level caused by α-amanthin. The use of aucubin or β-glucosidase alone does not show anti-hepatitis B virus activity, but when the two are pre-insulated, they show strong anti-hepatitis B virus activity. It does not have antiviral effect by itself, but when it is precultured with glucosidase, it will produce obvious antiviral effect. 2. Anti-oxidation and anti-aging effect Free radicals are toxic substances that damage themselves continuously produced in the process of body metabolism. The free radicals in the human body are mainly oxygen free radicals, which can peroxidize the unsaturated fatty acids on the cell membrane, destroy the biological membrane structure, and form lipofuscin, which is one of the main characteristics of aging. Li Farong and others studied the scavenging effect of aucubin on free radicals produced in chemical systems and its protective effect on oxidative damage to tissue homogenates, mitochondria, and microsomes. Collagen is a kind of high molecular protein. Its filamentous collagen fibers can make skin strong and elastic. With the increase of age, human collagen will gradually lose, skin will gradually lose elasticity and become thinner and aging, and a series of aging phenomena such as stains and wrinkles will appear. Studies have found that Eucommia ulmoides leaves water extract and methanol extract can promote collagen synthesis and achieve the purpose of anti-aging. The best experimental group extract contains a large amount of aucubin. 3. Other bioactive aucubin has obvious antihypertensive effect, long-lasting antihypertensive without any adverse reactions, and has a two-way regulation function on blood pressure, which is unmatched by chemical antihypertensive drugs. Eucommia leaf extract powder has anti-fatigue effect, and it contains aucubin. Sapocin can stimulate the parasympathetic center, accelerate the transfer and elimination of uric acid, and there is no "rapid tolerance" phenomenon; it can also antagonize the uterine contraction caused by acetylcholine in vitro; it also has anti-tumor activity. |
| application | 1. a considerable number of proprietary Chinese medicines with heat clearing, diuresis, blood pressure lowering and liver protection included in the "drug standards" of the Ministry of health of the medical and health industry contain aucubin and are the main components. Such as Eucommia ulmoides tablet, has a variety of pharmacological effects such as antihypertensive, diuretic, antibacterial, antiviral, anti-aging, and its main component is aucubin. At present, in the production of compound litchi grass granules and other drugs, aucubin has been taken as one of the important indicators of quality control. The eucommia health tea with eucommia leaves as the main ingredient has the functions of clearing away heat and detoxification, reducing blood pressure and reducing fat, losing weight and strengthening body. 2. Daily chemical industry With the enhancement of consumption awareness and the improvement of consumption level, hairdressing products have become people's daily consumption necessities from luxury goods. Because Chinese herbal medicine often has both nutritional and curative effects, and the effect is mild, it is very suitable as a cosmetic additive. The aucubin, which is widely found in Chinese herbal medicines, can react with amino acids to form colored products, and can also be decomposed by dilute acids and enzymes. Depending on its dosage, it can generate brown-black to black dendritic polymer precipitates. The hair fiber has strong adhesion, natural color, no irritation to the skin, and is a permanent hair dye. 3. Japanese scholars in the feed industry have concluded in recent years that Eucommia ulmoides is a rich feed additive. Eucommia ulmoides leaf powder mixed into livestock, poultry and fish feed can improve their immunity and reduce the occurrence of diseases. This is because adding a substance containing aucubin to the feed can inhibit the growth of Gram-negative and positive bacteria and reduce the loss of nutrients. (2016-01-13) |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has the effects of clearing dampness and heat, urinating, analgesia, lowering blood pressure, protecting liver and liver, and anti-tumor. It can promote stem cell regeneration and obviously inhibit the replication of hepatitis B virus DNA. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.