Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.481-53-8
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
from Citrus
| Overview | Tangeretin is one of the effective components of orange peel, which has been proved to belong to phenolic compounds, properties are colorless crystals or crystalline powder, odor aromatic, melting point 50 ℃ ~ 51 ℃, boiling point 232 ℃, volatile, difficult to dissolve in water, soluble in ethanol, ether and other organic solvents, it has a good effect on the treatment of animal acariasis. Compared with organic phosphorus, organic nitrogen and organic chlorine, it has the advantages of small toxic and side effects, low residue and no environmental pollution. For clinical treatment, there are disadvantages such as high cost, not easy to make easy to use the preparation and so on. Hesperidin is widely used in organic chemistry and life science. As the content of hesperidin in plants is low, and the price is expensive, so the study of hesperidin in our country is lagging behind. China is rich in citrus resources, and the extraction and application of hesperidin have broad prospects. figure: Orange Peel |
| Source | hesperidin and naringin, hesperidin, nobiletin and other flavonoids coexist in Rutaceae or Euphorbiaceae plants. |
| extraction | hesperidin is mainly extracted from plants of Rutaceae or Euphorbiaceae, and the extraction methods include recrystallization, column chromatography, high-speed countercurrent chromatography and supercritical carbon dioxide extraction. recrystallization method: Danxi orange is a famous citrus variety in the United States. The study found that the cold pressed orange oil made from Danxi Orange was centrifuged and frozen for a long time to form a yellow precipitate, and further removed limonene and recrystallized to obtain white crystalline hesperidin. As a by-product, the coproduction of hesperidin with cold-pressed orange oil can greatly reduce its production cost. column chromatography: column chromatography is a method of extracting hesperidin from sweet orange, fructus aurantii, Danxi orange and Croton pubescens by mixed organic solvent gradient elution. High-Speed Countercurrent Chromatography: High-Speed Countercurrent Chromatography, (HSCCC) is a liquid-liquid partition chromatography technique. Compared with other chromatographic separation methods, HSCCC does not use any solid carrier or support as a stationary phase, and the sample only realizes efficient separation and pure product preparation in a short time by the difference of distribution between immiscible two-phase solvents, in recent years, it has been paid attention to and applied in the field of extraction of natural products. supercritical carbon dioxide extraction method: supercritical carbon dioxide has a special effect on the dissolution of some natural products. The principle of supercritical carbon dioxide extraction technology is to use the relationship between the solubility of supercritical carbon dioxide and its density, that is, the extraction is carried out by using the influence of pressure and temperature on the solubility of supercritical carbon dioxide. In the supercritical state, the supercritical carbon dioxide is contacted with the substance to be separated, so that it selectively extracts the components of different polarity, boiling point and molecular weight in sequence, and then uses reduced pressure, the supercritical fluid is changed into ordinary gas by heating, and the extracted substance is completely or basically precipitated, so as to achieve the purpose of separation and purification. |
| Application | Medicine: hesperidin has a good inhibitory effect on liver cancer cell line SMMC -7721, hesperidin can effectively inhibit the growth of leukemia cancer cells by HL-60, and has no obvious toxic and side effects on normal immune cells. In addition, hesperidin can be used in the treatment of oral cancer and in the treatment of breast cancer. Zoology: Tangerine can treat animal acariasis, and the toxic side effect is small, the residue is low, has the advantages of Chinese herbal medicine preparation. |
| references | [1] Yu Hongwei, Han Weirong, Peng on Tuesday, etc. Research progress on extraction and application of hesperidin [J]. Jiangsu Agricultural Sciences, 2012, 40(3):249-252. [2] Xu Lanying, Zhao Hui, Zhang Ting, etc. Extraction, isolation and modification of hesperidin and its inhibitory effect on human hepatic stellate cell LX-2 [J]. Food Science, 2015, 36(23):43-46. [3] Li Jinyan. Effects of hesperidin on proliferation and apoptosis of human glioblastoma cells [J]. Gerontology of China, 2017, 37(12). |
| Chemical properties | soluble in methanol, DMSO and other solvents. |
| Use | hesperidin is a flavonoid found in the peel of citrus fruits and has natural antifungal properties. Hesperidin has been shown to inhibit intercellular communication induced by anti-tumor promoters and cell proliferation of some cancer cell lines A flavonoid found in the peel of citrus fruits, inhibition of anti-tumor promoter-induced intercellular communication and inhibition of cell proliferation in several cancer cell lines has been demonstrated. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.