Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 19831957301
Tel: +86 15632927689
Tel: +86 18233902561
Tel: +86 19903295909
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 15383190639
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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CAS NO.50-14-6
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Density | 0.9784 (rough estimate) |
| Melting Point | 114-118°C(lit.) |
| Boling Point | 460.3°C (rough estimate) |
| Specific Rotation(α) | 82 º (c=3, in acetone 25 ºC) |
| Flash Point | 14 °C |
| Water Solubility | Soluble in ethanol, water, methanol, dimethylformamide, and dimethyl sulfoxide. |
| Solubility | Soluble in ethanol (1:2), ether (1:2), acetone (1:10) and chloroform (1:0.7), insoluble in water. |
| Vapor Presure | 7 x l0-7 Pa (20 °C), est.) |
| Appearance | White needle crystal or crystalline powder |
| Color | white to yellowish |
| Merck | 14,10018 |
| BRN | 1916682 |
| pKa | 14.74±0.20(Predicted) |
| Storage Condition | -20°C |
| Sensitive | `sensitive` to water and moisture, `sensitive` to light |
| Refractive Index | 1.5100 (estimate) |
| MDL | MFCD00166988 |
| Physical and Chemical Properties |
Melting Point: 118 - 119 |
| Use | Mainly used for the prevention and treatment of rickets, osteomalacia, infantile tetany, etc |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
| introduction | there are currently at least 10 kinds of vitamin d known, but the most important ones are vitamin D2 (ergocalciferol) and vitamin D3 (bile calcification aldehyde). Vitamin D2 is produced by ergosterol in plants irradiated by ultraviolet rays, but the stock in nature is very small. Vitamin D3 is transformed from the 7-dehydrocholesterol contained in the human epidermis and dermis through ultraviolet radiation in sunlight. The safety of vitamin D2 is better than that of vitamin D3. Vitamin D refers to a group of fat-soluble steroid compounds, which have anti-rickets effects, so it is called anti-rickets vitamins. At present, there are at least ten kinds of sterols with vitamin D activity. The main ones are the ergosterol in vegetable oil or yeast. After sunlight or ultraviolet radiation, it produces vitamin D2, also known as calciferol or ergociferol. Therefore, ergosterol is called provitamin D2; the other is that the human body can convert cholesterol into 7-dehydrocholesterol and store it under the skin. Under sunlight and ultraviolet radiation, the latter can be converted into vitamin D3, also known as cholecalciferol, so 7-dehydrocholesterol is also called vitamin D3. The structures of vitamin D2 and vitamin D3 are very similar. They are both B- ring open-loop derivatives of the precursor sterol. The difference between the two is that there is an extra double bond and a methyl group on the side chain of vitamin D2. Vitamin D2 and vitamin D3 are colorless or white crystals, both odorless, melting points are 115~118 ℃ and 84~85 ℃, insoluble in water, soluble in ethanol, ether, acetone, etc., slightly soluble in vegetable oil. It is unstable in air and sunlight, and is easily inactivated in humid air, but vitamin D3 is more stable than vitamin D2. The physiological effects of the two in the human body are the same; their main function is to maintain the normal metabolism of calcium and phosphorus, and promote the deposition of calcium and phosphorus into bones and tissues, so this product can be used to prevent and treat metabolic diseases such as rickets and osteomalacia Bone disease. Vitamins D2 and D3 have the same effect on mammalian cows and pigs. However, the activity of vitamin D3 on poultry (birds) is ten times stronger than that of vitamin D2. |
| pharmacological action | vitamin D2 is a vitamin drug, which can promote the absorption of calcium and the reabsorption of phosphorus by renal tubules, increase the concentration of blood calcium and phosphorus, cooperate with parathyroid hormone calcitonin, promote the release of calcium carbonate from old bones, and maintain and regulate the normal concentration of plasma calcium and phosphorus. |
| indications | 1. for prevention and treatment of vitamin d deficiency. Such as: absolute vegetarians, patients with parenteral nutrition, pancreatic insufficiency with malabsorption syndrome, hepatobiliary diseases (liver function damage, liver cirrhosis, obstructive jaundice), small bowel diseases (fatty diarrhea, localized enteritis, long-term Diarrhea), gastrectomy, etc. 2. For the treatment of chronic hypocalcemia, hypophosphatemia, rickets and osteomalacia with chronic renal insufficiency, familial hypophosphatemia and hypoparathyroidism (postoperative, idiopathic or pseudoparathyroidism). 3. It is used to treat acute, chronic and potential hand-foot convulsion and idiopathic hand-foot convulsion after surgery. |
| deficiency | vitamin d2 is a kind of nutrient that people are very familiar with, and it is also an essential substance to maintain the health and stability of various functions inside the human body. if vitamin d2 deficiency occurs in the human body, it will cause rickets, rickets, twitches of hands and feet and other abnormal diseases, therefore, we must attach great importance to and understand vitamin d2. |
| function and function | 1, vitamin d2 may help us effectively improve the absorption of calcium and phosphorus in our body, making the levels of plasma calcium and plasma phosphorus in our body at a relatively saturated level, thus effectively ensuring the health and stability of all functions in our body. 2. In addition, vitamin d2 can also help us to promote the growth of the body and calcification of bones, as well as the health and integrity of teeth. Therefore, vitamin d2 has a very important practical significance for the prevention and treatment of osteoporosis, which is a part we need to understand. 3. Vitamin d2 can help the intestinal wall to increase the absorption of phosphorus, and it can further increase the reabsorption of phosphorus in the renal tubules. 4. Vitamin d2 has very important practical significance for maintaining the normal level of citrate in the blood. This is also one of the functions of vitamin d2 that we must not ignore. 5. Finally, vitamin d2 can also help us effectively prevent the loss of amino acids through the kidney area. |
| adverse reactions | constipation, diarrhea, persistent headache, loss of appetite, metallic taste in mouth, nausea and vomiting, thirst, fatigue and weakness. Bone pain, turbid urine, convulsions, high blood pressure, increased eye sensitivity to light stimulation, arrhythmia, occasional mental abnormalities, skin itching, myalgia, severe abdominal pain (sometimes misdiagnosed as pancreatitis), nocturnal polyuria, weight loss. Short-term intake of large doses or long-term overdose of vitamin D2 can lead to severe toxic reactions. Hypercalcemia caused by vitamin D2 poisoning. |
| application | vitamin D2 is a steroid derivative, an active substance related to calcium and phosphorus metabolism, and plays an important role in the prevention and treatment of rickets in children and osteoporosis in the elderly. at present, there are 96 kinds of pharmaceutical preparations with vitamin D2 as the main component. Vitamin D2 is also an indispensable and important additive in feed, it can significantly improve the egg production rate and lean meat production rate of livestock; vitamin D2 is also a synthetic raw material for drugs such as calcitriol, calcitriol, carpothritol and paricalcitol, so it is a very important Pharmaceutical and fine chemical products. |
| toxicity | acute poisoning dose 100mg/d (adult, oral). The lethal dose of mice was 20mg/kg(6 days). Overdose is prone to poisoning. GRAS(FDA,§ 182.5950,2000). LD50 42mg/kg (rat, oral). |
| usage limit | GB 14880-94(μg/kg): liquid milk 10~20; Margarine 125~156; Dairy products 63~125; Milk and milk drinks 10~40; Infant food 50~115.GB 2760-2002(pg/kg): solid beverage, ice cream, 10~20; Lotus root starch 50~10.; Soybean milk powder, soybean powder, 15~60; Soymilk, soy milk, 3~15; Jelly 10~40; Instant breakfast cereal, 12.5~37.5; Puffed sandwich food 10~60. FDA,§ 184.1950(IU/100g;2001): breakfast cereal 350; Granular and pasty products 90; Milk 42; Dairy products 89. |
| use | biochemical research; Clinical drugs are fat-soluble vitamins, which promote intestinal calcium and phosphorus absorption and help bone calcification. They are clinically used to prevent and treat rickets in children and osteomalacia in adults. Vitamin D2 can maintain the normal metabolism of calcium and phosphorus, and can promote the body's absorption of calcium and phosphorus. When lacking, children are prone to rickets. According to regulations in China, it can be used for fortified margarine with an amount of 125~156 μg/kg; 63~125 μg/kg in fortified dairy products; 50~100 μg/kg in fortified infant food; 10~40 μg/kg in fortified milk and milk drinks; the maximum amount used in fortified solid beverages and ice cream is 10~20 μg/kg. It is mainly used to prevent rickets and osteomalacia. It can be converted from wheat sterol by ultraviolet light irradiation. It is mainly used for the prevention and treatment of rickets, osteomalacia, and tetany in infants. |
| production method | ergosterol is dissolved in ethanol, the ring is opened under ultraviolet light, the reaction liquid is concentrated under reduced pressure, frozen, and filtered. Filter liquid nitrogen, concentrate to dry under reduced pressure to obtain vitamin D2 crude oil, which is refined to obtain the finished product. Vitamin D2 naturally exists in liver, milk and egg yolk. The industrial production method is to first extract ergot calcium alcohol that cannot be absorbed by the human body from vegetable oil or yeast, and then dissolve it in chloroform or cyclohexane. Then use ultraviolet rays in a quartz glass flask to convert it into vitamin D2. ergosterol ethanol solution is irradiated by ultraviolet rays, and 9,10 bonds are broken to obtain crude vitamin D2, which is then esterified with 3, 5-dinitrobenzoyl chloride, and hydrolyzed and purified under alkaline conditions to obtain this product. |
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.