Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 19831957301
Tel: +86 15632927689
Tel: +86 18233902561
Tel: +86 19903295909
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 15383190639
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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CAS NO.501-36-0
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molar Mass | 167.21 |
| Density | 1.1222 (rough estimate) |
| Melting Point | 187°C (dec.)(lit.) |
| Boling Point | 295.79°C (rough estimate) |
| Flash Point | 163.4°C |
| Solubility | Easily soluble in water, hardly soluble in ether, |
| Vapor Presure | 3.18E-05mmHg at 25°C |
| Appearance | Colorless crystal (ethanol-ether) |
| Color | White to Off-White |
| Merck | 14,9012 |
| pKa | pKa 9.60±0.02(H2Ot = 25.0±0.5I = 0.01)(Approximate) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.4680 (estimate) |
| MDL | MFCD00002370 |
| Physical and Chemical Properties | Hydrochloride, colorless crystal (ethanol-ether), melting point: 166 ℃-167 ℃,[α]27D-52. (C = 7.6 mg/ml, anhydrous methanol). In strong acid, strong base ion exchange resin chromatography separation is prone to racemization. Crystallization, melting point: 184 ℃-185 ℃; Hydrochloride crystallization, melting point: 151 ℃-152 ℃, easily soluble in water; Btartrate, 188 ℃-189 ℃ (partial decomposition), easily soluble in water, hardly soluble in ether, almost insoluble in chloroform and ether. |
| Use | Used as a vasopressor |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
in fructus aurantii and fructus aurantii from different origins
| Plant Source: | fructus aurantii immaturus |
| Character | White needle-like crystalline powder; Slightly gas, bitter. |
| plant extract | synephrine a biologically active substance, mainly from fructus aurantii, pericarpium citri reticulatae, green husk and other Rutaceae plant extract, is the effective component of traditional Chinese medicine fructus aurantii immaturus play an important role, with strong heart, increase the amount of cardiac output, contraction of blood vessels, high total peripheral vascular resistance to the left ventricular pressure and arterial blood pressure to rise the role of anti-Shock and the role of weight loss, but because of the structure of synephrine similar to the jute base with the excitation of central nervous, the potential side effects that lead to cardiovascular disease have been restricted in recent years in the United States, Canada and other countries. Figure 1 shows the extract of Citrus aurantium, synephrine |
| pharmacological effects | The pharmacological effects of synephrine are mainly adrenergic receptor agonists, heart receptors also have a certain Excitatory effect; Can shrink blood vessels, hypertension, expansion of bronchial and tracheal; Also has a certain weight loss, antidepressant effect, clinically, it is mainly used for the treatment of bronchial asthma and hypotension collapse and Shock orthostatic hypotension accumulation of stomach drop, synephrine is a pure natural stimulant, without any side effects and positive reaction, has been widely used in pharmaceutical food and beverage industries. |
| separation and extraction methods | at present, there is no report on the mature process for the extraction and separation of high purity synephrine, and more commonly used methods are mainly cation beam transesterification and hydrochloric acid percolation method. The market demand for Citrus aurantium extract and hesperidin containing synephrine is large. Therefore, it is necessary to establish a comprehensive utilization process of Citrus aurantium, and extract synephrine and hesperidin from Citrus aurantium step by step. |
| analytical method of content | as the market demand for synephrine increases, the value of synephrine doubles, for its content detection methods and other aspects of the research is also in-depth, the current reported methods are (1) reversed-phase high performance liquid chromatography (RP-HPLC), (2) packed column Supercritical fluid chromatography (SFC), (3)HPLC method, (4) thin layer scanning method, (5) high performance liquid chromatography and thin layer chromatography scanning method, etc. |
| determination of synephrine content in fructus aurantii of Rutaceae family by HPLC | [sample] Dried and mature pericarp of orange Citrus teticullocally and its cultivars, the medicinal herbs are named "Tangerine Peel" and "pericarpium citri reticulatae", or Citrus aurantiwm L. And its cultivated varieties of dried immature fruit, or sweet orange C. The dried young fruit of sinensis Osbeck, the medicinal material is called fructus aurantii; Or the pericarp of the dried young fruit or immature fruit of orange and its cultivated varieties, the medicinal material is called green husk. (1) chromatographic conditions column: Micropak MCH-5C18; Mobile phase: methanol solution of 0.02mol/L phosphoric acid and 0.2% sodium dodecyl sulfate; Column temperature: 50 ℃; Flow rate: 1 ml/min; detection wavelength: 275nm. (2) preparation of reference solution 4mg of synephrine reference was obtained by dissolving and diluting to 10ml with 0.01mol/L hydrochloric acid. (3) preparation of sample solution take 1g of sample fine powder, weigh it finely, put it in a 50ml plug Erlenmeyer flask, add 20ml of methanol, pack it, extract it with ultrasonic oscillation for 15min, and let it stand for 4H, filter, add 5ml of the filtrate to a 10ml plug centrifuge tube, imdissolve and evaporate to dryness at 90 ℃, cool, add 2ml of 0.01mol/L hydrochloric acid and 2ml of chloroform, plug and shake, centrifuge, the supernatant was taken for use. (4) measurement: 10ml of each of the sample solution and the reference sample solution were accurately extracted, injected, and measured according to chromatographic conditions. (5) determination results FIG. 2 shows the content of synephrine (n = 6,%) |
| Use | vasopressor. For Shock, for heart failure, treatment of bronchial asthma and surgery and anesthesia at the end of blood pressure, collapse and Shock, body, low blood pressure, etc. used as vasopressor α-adrenoceptor agonist, vasoconstrictor. |
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.