Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 19831957301
Tel: +86 15632927689
Tel: +86 18233902561
Tel: +86 19903295909
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 15383190639
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Contact Suppliers
CAS NO.512-06-1
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C27H42O3 |
| Molar Mass | 414.62 |
| Density | 1.13g/cm3 |
| Melting Point | >180°C (dec.) |
| Boling Point | 527.1°C at 760 mmHg |
| Specific Rotation(α) | -123 |
| Flash Point | 272.6°C |
| Solubility | Ethanol : 10 mg/mL (24.12 mM; Need ultrasonic) |
| Vapor Presure | 2.59E-13mmHg at 25°C |
| Appearance | Powder |
| Color | White to Pale Beige |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.564 |
| MDL | MFCD20377911 |
| overview | diosgenin (diosgenin) is commonly known as saponin. it is a kind of steroidal saponin naturally synthesized by plants and belongs to spirostanol glycosides (fig. 1). its structural formula is C27H42O3 and its relative molecular mass is 414.63. it is widely found in legume and dioscorea plants. The main source of diosgenin is the seeds of fenugreek Trigonella foenum-graecum l, it can also be extracted from tubers of Dioscorea zingiberensis C. H. Wright of Dioscorea zingiberensis, D. nipponica Makino of Dioscorea zingiberensis, D. panthaica Prain et Burkill of Dioscorea zingiberensis, D. nipponica Makino ssp. rosthornii (Prain et Burkill) C. T. Tin and other plants by hydrolysis, fermentation, extraction and other methods [2]. diosgenin is an important basic raw material for the production of steroid hormone drugs. Steroid hormones have strong anti-infection, anti-allergy, anti-virus and anti-shock pharmacological effects. They are important for the treatment of rheumatism, cardiovascular, lymphatic leukemia, cellular encephalitis, skin diseases, anti-tumor and rescue of critically ill patients Medication. diosgenin (diosgenin), as an important natural steroidal sapogenin, has a wide range of sources and is mainly obtained from cucurbita. It is an important raw material for the synthesis of steroid hormone drugs. It has many significant pharmacological effects such as anti-tumor, anti-inflammatory and anti-oxidation, and has high medicinal value. |
| preparation method | is obtained by hydrolysis and extraction using chuandi dragon crude medicine or turmeric as raw materials. Chinese chemist Huang Minglong and others used diosgenin as raw material and successfully synthesized cortisone with a seven-step reaction. Different preparation methods of diosgenin. Among them, the improved methods using auxiliary methods such as ultrasound, microwave or enzymatic hydrolysis have not completely separated from the process of acidolysis, causing certain pollution to the environment; and the method of preparing diosgenin by microbial fermentation has mild reaction conditions and by-products. The characteristics of less, no pollution, etc., provide a new idea for the production of diosgenin. Microbial fermentation method Microbial fermentation method has mild conditions, no acidolysis process, no pollution, and clear target product. Dong Yuesheng and others will be screened out can hydrolyze dioscorea saponin to produce aglycone Trichoderma and Aspergillus oryzae, directly connected to the raw material Dioscorea zingiberensis culture fermentation, so as to prepare diosgenin. The yield of diosgenin in this method is 1-2 times that of general acidolysis and microwave-assisted method, and acidolysis is not required. Zhang Chuan will wait for feeding. The microbial transformation of strain YM32139 and rhizome of yellow yam was studied by solid transformation. The results showed that the original components in yellow yam were mainly converted into diosgenin. Yu Dong et al. screened a strain that efficiently transforms to produce diosgenin, and carried out liquid fermentation with Dioscorea zingiberensis, and optimized the fermentation conditions. The highest conversion rate reached 85%. With the deepening of the research on diosgenase, a variety of different strains have been screened out from microorganisms. These strains can secrete proteases that are transformed into diosgenin. The reaction conditions, purification and properties of the enzymes have also been further studied. |
| Anti-tumor effect | In vitro and in vivo studies have shown that diosgenin is cytotoxic to a variety of tumor cells, including breast cancer cells, colon cancer cells, prostate cancer cells, lung cancer cells, gastric cancer cells, osteosarcoma cells, etc, it can play an anti-tumor effect by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, blocking cell cycle and anti-tumor metastasis. From the anti-tumor pharmacological effects of diosgenin and its mechanism research, it can be seen that diosgenin has anti-colon cancer, prostate cancer, breast cancer, liver cancer, gastric cancer, oral cancer and skin cancer and other tumors. Summarizing the possible mechanism of diosgenin's anti-tumor effect (Figure 1), it can be seen that diosgenin plays an anti-tumor effect by adjusting a variety of cell signaling pathways, and is closely related to many important molecular targets such as growth, differentiation, apoptosis, and tumor formation. Figure 1 The possible anti-cancer mechanism of diosgenin at the cellular level |
| use | this product is an important steroidal sapogenin and an important raw material for semi-synthetic steroidal compounds. Diosgenin is subjected to ring-opening, oxidation, hydrolysis and elimination reactions to obtain pregnenone alcohol. After oximation, rearrangement and hydrolysis, dehydroepiandrosterone can be prepared. These intermediates have important value in drug production. |
| References | [1] Diosgenin. Bailian Database. [Citation Date 2017.09.09] [2] He Yan, Wang Jishuang, Zhang Peng, Hua Zichun. Research Progress on Pharmacological Effects and Mechanisms of Diosgenin [J]. Chinese Herbal Medicine, 2013,44(19):2759-2765. [2017-09-09]. [3] Zhao Min, Tan Dawei, Yu River, Kang Liping, Zhou Wenbin, Xiong Chengqi, Zhao Yang, ma Baiping. Research Progress on Preparation Methods of Diosgenin [J]. Chinese Herbal Medicine, 2013,44(13):1860-1866. [2017-09-09]. |
| Biological activity | Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes liver X receptor (LXR) activation in luciferase ligand determination. Yamogenin (Neodiosgenin) inhibits triglyceride (TG) accumulation by inhibiting gene expression of fatty acid synthesis in HepG2 hepatocytes. |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.