Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.520-18-3
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| color index | 75640 |
| (IARC) carcinogen classification | 3 (Vol. 31, Sup 7) 1987 |
| overview | flavone is a natural polyphenol compound, which exists in a large number of fruits and vegetables eaten by human daily. it has many biological activities such as antioxidant, anticancer and anti-inflammatory, and has always been a hot research topic at home and abroad. kaempferol (kaempferol) is a kind of flavonoid compound, also known as kaempferol -3, kaempferol, kaempferol, thyphene III, widely exists in fruits, vegetables and Chinese herbal medicine and other natural plants. |
| effect | kaempferol has antioxidant, anti-inflammatory, anti-cancer, prevention and treatment of diabetes, atherosclerosis and osteoporosis, as well as protection of nerve, liver and myocardium, inhibition of protein kinase and other nutritional and health effects. As a health food and medicine, kaempferol has a very broad market. |
| preparation | 1) hydrolysis to prepare hydroxyacetophenone intermediate 1.1) put 30g of dihydromyricetin with a content of more than 98% into the reactor, then add 400g of sodium hydroxide solution with a mass fraction of 15%, stir and mix evenly, raise the temperature and reflux, and carry out hydrolysis reaction; High performance liquid chromatography monitoring, with the hydroxyacetophenone intermediate no longer increasing as the reaction control end point, after 2 hours, stop the reaction. Cooling to 30 ℃, slowly dropping 50% hydrochloric acid solution into the reaction solution, adjusting pH to about 6.2, stirring for 2 hours, standing for 1 hour, filtering to obtain light yellow viscous solid. 1.2) 150g of 95% ethanol is added to the light yellow viscous solid obtained in step 1.1), heated and refluxed for 1h, then filtered to obtain a solid while hot, then 90g of 95% ethanol is added to the solid, heated and refluxed for 1h again, beaten to room temperature, let stand for 2h, then filtered and dried to obtain a light yellow solid, I .e. hydroxyacetophenone intermediate (2-hydroxy -1-(2,4, 6-trihydroxyphenyl) acetyl) 17.8g. 2) Catalytic closed-loop preparation of crude dihydrokaempferol 2.1) Put 17.8g of hydroxyacetophenone intermediate obtained by the reaction in step 1.2) into the reaction bottle, add DMF92g, and stir to completely dissolve the hydroxyacetophenone intermediate. 2.2) Add 3.55g of proline to the solution in step 2.1), raise the temperature to 65 ℃ and keep the temperature unchanged, dissolve 13.9g of p-hydroxybenzaldehyde with 20gDMF and slowly drop it into the reaction bottle for about 2 hours. After dropping, the temperature was raised to 70 ℃ for heat preservation, and the catalytic closed-loop reaction was carried out. High performance liquid chromatography monitoring was carried out. The dihydrokaempferol intermediate was no longer increased as the reaction control end point, and the reaction ended after about 7 hours. 2.3) The solution obtained in step 2.2) is reduced to room temperature, 350g of 5% glacial acetic acid solution is added, stirred for 2 hours, and solid is slowly precipitated. Filter, wash the filter cake with water until neutral and dry to obtain 27.6g of crude dihydrokaempferol. 3) Oxidation Preparation of kaempferol 27.6g of crude dihydrokaempferol obtained in step 2.3) is put into a reaction bottle, 275ml of 65% ethanol is added, stirred evenly, 6g of anhydrous potassium carbonate is added, oxygen is introduced, then the temperature is raised and refluxed, the oxidation reaction is carried out, high performance liquid chromatography monitoring is carried out, the reaction control endpoint is no longer increased with kaempferol, and the reaction is over after about 8 hours. Drop to room temperature and leave overnight, filter to obtain yellow solid, add 200g of water, filter after reflux for 2h, wash and dry the filter cake to obtain 22.3g of kaempferol with 98% content (HPLC). |
| traits | kaempferol is brown to light yellow crystalline powder; The gas is slight and the taste is pungent. |
| pharmacological effects | kaempferol has anti-cancer, anti-fertility, anti-epilepsy, anti-inflammatory, antioxidant, antispasmodic, anti-ulcer, choleretic diuretic, antitussive and other effects. |
| use | an effective osteoclast bone resorption inhibitor. It has anti-cancer, anti-fertility, anti-epilepsy, anti-inflammatory, antioxidant, antispasmodic, anti-ulcer, choleretic and diuretic, and cough. a flavonol. It can restore the deformation of mouse fibroblasts treated with phorbol ester or v-H-ras-transformed NIH 3T3 cells. It can significantly induce nuclear DNA degradation, accompanied by lipid peroxidation. Inhibition of DNA reattachment catalyzed by topoisomerase I. |
| production method | after the plant material is crushed, the plant material is extracted with water or ethanol; then polyamide (polyamide) is used for adsorption, and after elution, it is separated from other flavonoids by chromatography or purified by high pressure liquid chromatography (HPLC). |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.