Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province
MaxCard:
Ms.AnnaCAS NO.53-59-8
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Introduction
Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate nucleotide (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. There are two states of oxidized (NAD) and reduced (NADH) in mammals. The oxidized (NAD) has the maximum ultraviolet absorption spectrum at 260nm. Through various deaminases, it accepts a hydrogen atom and an electron from the substrate., Becomes a reduced type (NADH), has the maximum absorption at 340nm.
β-nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of ADP ribose moiety in ADP ribosylation reactions, and also as a second messenger molecule ring ADP ribose Precursor. β-nicotinamide adenine dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD to remove acetyl groups from proteins.
Physiological functions and effects
Nicotinamide adenine dinucleotide participates in various physiological activities such as cell substance metabolism, energy synthesis, cell DNA repair, and plays an important role in the body's immune ability. In a healthy state, the concentration of nicotinamide adenine dinucleotide in the human body is stable, maintaining the normal function of various cells. The concentration of nicotinamide adenine dinucleotide in the body determines the process and degree of cell senescence, and the decrease of concentration will accelerate the process of cell senescence. Studies have shown that NAD has a protective effect on renal infarction caused by ischemic surgery, and can significantly reduce the levels of urea nitrogen and creatinine in serum. NAD has a protective effect on renal tubular injury caused by ischemic surgery. NAD (nicotinamide adenine dinucleotide, Nicotinamideadeninedinucleotide, referred to as NAD) can effectively protect kidney injury caused by renal ischemia. NAD has important application value in the preparation of drugs for the prevention and treatment of renal ischemic injury. In addition, nicotinamide adenine dinucleotide has certain applications in the preparation of drugs for the treatment of inflammatory pain. NAD participates in the regulation of formalin and complete Freund's adjuvant (CFA) through NAD-dependent deacetylase SIRT1 and SIRT2 participate in the inhibition of inflammatory pain by NAD through different mechanisms, thus achieving an analgesic effect on inflammatory pain.
Preparation
The preparation method of nicotinamide adenine dinucleotide proposed by CN201511022464.3 includes the following steps:
S1, broken cells: yeast cells are added into hydrochloric acid aqueous solution and soaked for 0.5-2.5h. after temperature difference wall breaking treatment, ceramic membrane is used for filtration, and the filtrate is taken to obtain clear liquid a;
S2, concentration: ultrafiltration of clear liquid a obtained from S1, nanofiltration of ultrafiltration to obtain concentrated liquid B, and adjusting the pH = 2-2.5 of concentrated liquid B with hydrochloric acid aqueous solution to obtain concentrated liquid c;
S3, elution: the concentrated solution c obtained in S2 is passed through D152 resin column, eluted with ammonia water, eluent d is collected, pH = 7-8 of eluent d is adjusted with hydrochloric acid aqueous solution, then the concentrated solution c is passed through 717 resin column, eluted with potassium chloride aqueous solution, and comprehensive solution e is collected;
S4, separation: nanofiltration of composite liquid e obtained in S3 to obtain concentrated solution f; Adjust the pH = 1-3 of concentrated solution f with nitric acid aqueous solution, add acetone to precipitate, and centrifuge to obtain solid g;
S5, purification: the solid G obtained in S4 is dissolved in water, subjected to preparative chromatography, desalination, separation, collection of separation liquid, concentration, freeze-drying to obtain nicotinamide adenine dinucleotide.
Production method
yeast is extracted in boiling water, lead acetate is acidified and precipitated to obtain crude product, which is treated with formic acid cation exchange resin column and refined.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.