Keywords

• Ethanol,2,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-(6CI,8CI)
• Dypyridamole
• 2,2',2'',2'''-[[4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl]dinitrilo]tetraethanol

Quick Details

• ProName: Dipyridamole 58-32-2
• CasNo: 58-32-2
• Molecular Formula: C24H40N8O4
• Appearance: Light yellow
• Application: Anti-platelet aggregation drug, corona...
• DeliveryTime: 7-10 working days
• PackAge: In plastic outside weave or according ...
• Port: port of Qingdao、port of Tianjin
• ProductionCapacity: 500 Kilogram/Week
• Purity: >99%
• Storage: -15°C
• Transportation: We ship goods via DHL, Fedex, UPS, TNT...
• LimitNum: 1 Kilogram
• Grade: Industrial Grade,Food Grade,Pharma Gra...
• Shelf Life: Two years

Superiority

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Exam

Authoritative Data Verified Data

chlorine-containing compounds

take about 20mg of this product, according to the oxygen flask combustion method (General rule 0703) for organic damage, 0.4% sodium hydroxide solution 20ml as the absorption liquid, once the combustion is completed, strong shaking for 15 minutes, add 10ml of dilute nitric acid, move to 50ml Nessler's colorimetric tube, check according to the chloride inspection method (General 0801), and operate with the control solution (the same method as the test sample), however, the test article is not contained in the filter paper during combustion, and 4.0 of standard sodium chloride solution is added), and it should not be more concentrated (0.20%).

Related substances

take this product, add methanol to dissolve and dilute to make 1.0 mg of the solution was used as a test solution, and an appropriate amount was quantitatively diluted with methanol to prepare a solution containing 10ug per 1 ml as a control solution. According to the high performance liquid chromatography (General rule 0512) test, with eighteen alkyl silane bonded silica gel as filler; Disodium hydrogen phosphate solution [take disodium hydrogen phosphate 250mg, add water 250ml, dissolve, Dropwise add phosphoric acid solution (1-3) the pH value was adjusted to 4.6]-methanol (25:75) as the mobile phase; The detection wavelength was 288nm, and the number of theoretical plates was not less than 600 based on the dipyridamole peak. The LOLs of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).

residual solvent

take about 0.1g of this product, precision weighing, in the top empty bottle, Precision Add 5ml of N,IV-dimethylformamide to dissolve, seal, as a test solution; Separately take methanol, appropriate amount of acetone and ethyl acetate, precision weighing, quantitative dilution with N,N-dimethylformamide to make solution containing about 50ug in each lml, precision measuring 5ml, in the empty bottle, sealed, as a control solution. Test as residual solvent assay (General 0861 second method). With 6% cyanopropylphenyl-94% dimethylpolysiloxane (or polar similar) as the stationary liquid; The initial temperature is 50°C, maintained for 3 minutes, and the temperature is raised to 160°C at a rate of 40°C per minute, maintained for 3 minutes; the inlet temperature was 200°C; The detector temperature was 250°C; The headspace bottle equilibrium temperature was 80°C and the equilibrium time was 30 minutes. Take the reference solution into the headspace, the separation degree between the peaks of each component shall meet the requirements. Then the sample solution and the reference solution were injected with headspace, and the chromatogram was recorded. According to the external standard method to calculate the peak area, methanol, acetone and ethyl acetate residues should be in accordance with the provisions.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Dipyridamole Tablets

Authoritative Data Verified Data

This product contains dipyridamole (C24H40N304) should be 90.0%-110.0% of the label.

trait

This product is sugar-coated tablet or film-coated tablet, which shows yellow color after removing the coating.

identification

1. take this product, remove the coating, grind, weigh an appropriate amount (about 0.2g equivalent to dipyridamole), add three methane 20ml, stir, dissolve dipyridamole, filter, the solution was evaporated to dryness on a water bath, and the residue was subjected to the identification (1) and item test under the item of dipyridamole, showing the same results.
2. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
3. take an appropriate amount of fine powder of this product (about equivalent to dipyridamole lOOmg), add 10ml of chloroform, grind and dissolve, filter, evaporate the filtrate to dryness, dry the residue under reduced pressure, and determine it according to law. The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 557 figure).

examination

• Content uniformity take 1 tablet of this product, remove the coating, grind it, and use 0.Olmol/L hydrochloric acid solution was transferred to a 100ml measuring flask and added 0.Olmol/L hydrochloric acid solution, shaking to dissolve dipyridamole, and 0. Dilute Olmol/L hydrochloric acid solution to the scale, shake well, filter, take the continuous filtrate accurately, use 0.Olmol/L hydrochloric acid solution is diluted quantitatively to prepare a solution containing about 10ug of dipyridamole per 1 ml, and the absorbance is measured at the wavelength of 283nm by ultraviolet-visible spectrophotometry (General rule 0401), the content, calculated as the absorption coefficient of C24H40N804 is 625, shall be in accordance with the provisions (General 0941).
• dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (9-100) as the dissolution medium, the speed is rpm, operate according to law, after 30 minutes, take 10ml of solution, filter, take the appropriate amount of filtrate with precision, dilute quantitatively with dissolution medium to prepare 10ug of dipyridamole solution per lml, according to UV-visible spectrophotometry (General rule 0401), the absorbance was measured at the wavelength of 283nm, and the appropriate amount of dipyridamole control was taken, the dissolution medium was added to dissolve and quantitatively dilute to prepare a solution containing about 10ug of dipyridamole per 1 ml. The absorbance was measured by the same method, and the dissolution amount of each tablet was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
• others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; With disodium hydrogen phosphate solution [take disodium hydrogen phosphate l. After dissolving in 1000ml of water, add Dropwise phosphoric acid solution (1-3) To adjust the p H value to 4. 6]-methanol (25 : 75) is the mobile phase; The detection wavelength is 288nm, and the number of theoretical plates is not less than 1000 according to the dipyridamole peak. The resolution of dipyridamole peak and adjacent impurity peaks should meet the requirements.
• determination of this product 20 tablets, remove the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to dipyridamole 50mg), 100ml flask, add water 10ml, sonicate for about 15 minutes, add 75ml veratryl alcohol, shake for about 30 minutes to dissolve dipyridamole, dilute with methanol to scale, shake, filter, take 2ml continuous filtrate with precision, put it in 25ml measuring flask, dilute to the scale with mobile phase, shake well, as a test solution, take 20 u1 with precision, inject into liquid chromatograph, record chromatogram; Take an appropriate amount of dipyridamole reference, weigh accurately, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 40ug per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.

Dipyridamole injection

Authoritative Data Verified Data

This product is a sterile aqueous solution of Dipyridamole. Dipyridamole-containing (C24H40N604) shall be between 90.0% and 110.0% of the labeled amount.

trait

This product is yellow clear liquid, with fluorescence.

identification

1. take 2ml of this product, add 2ml of dilute hydrochloric acid, drop add 1% potassium chromate solution, that is, red-purple, after shaking, red-purple fading, add an excess of 1% potassium chromate solution, red-purple color was not reproduced.
2. take 1ml of this product and dilute it with 20ml of water to show green fluorescence. After adding acid
3. fluorescence disappeared.
4. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.

examination

• the pH value should be 2.5 to 4.5 (General 0631).
• Related Substances: dilute the product with mobile phase to prepare a solution containing about 1 mg of dipyridamole per 1 ml as a test solution, A solution containing 10ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 2 times (2.0%) the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 4.5 times (4.5%) of the main peak area of the control solution.
• bacterial endotoxin this product is taken and checked according to law (General rule 1143). The amount of endotoxin per 1 mg dipyridamole should be less than 8.8EU.
• others should comply with the relevant provisions under injection (General 0102).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; With acetate buffer (sodium acetate 6.8g, dissolved in water and diluted to 1000ml, the pH was adjusted to 5.1±0.1 with acetic acid-methanol (35:65) as the mobile phase; The detection wavelength was 276mn. The number of theoretical plates shall not be less than 2000 calculated by the peak of dipyridamole, and the degree of separation of the peak of dipyridamole from the adjacent impurity peaks shall meet the requirements.
• determination of precision: take an appropriate amount of this product (about 10mg equivalent to dipyridamole), put it in a 50ml measuring flask, dilute it to the scale with mobile phase, shake it well, and use it as a test solution, l0ul was accurately measured and injected into human liquid chromatograph, and the chromatogram was recorded. The appropriate amount of dipyridamole reference substance was accurately weighed, dissolved and diluted with mobile phase to prepare a solution containing about 0.2mg per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.