Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.5985-28-4
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Molecular Formula | C9H14ClNO2 |
| Molar Mass | 203.67 |
| Melting Point | 147-150°C |
| Boling Point | 341.1 °C at 760 mmHg |
| Solubility | DMSO : ≥ 52 mg/mL (255.31 mM) |
| Appearance | White to off-white (Solid) |
| Color | Off-White to Pale Beige |
| Storage Condition | Refrigerator |
| MDL | MFCD00050566 |
| In vitro study | Synephrine(0.1-30μm) acts on isolated rat aorta and has effective vasoconstrictor effect in a dose-dependent manner. This effect can be affected by Prazosin, brl15572, and Ketanserin but not SB216641 and propranol, indicating that Synephrine acts through its adrenergic alpha(1)-receptor, 5-HT(1D) receptor, and 5-HT(2A) receptor. Although Synephrine, 1R, 2s-norephedrine, and β-phenylethylamine have the same Ki value for all three subtypes, however, only Synephrine is a partial agonist of the α1A-AR subtype stably expressed in HEK 293 cells. EC50 is 4 µm, and 100 µm has the maximum response effect, equivalent to 55.3 % L-phenylephrine maximum response effect. Functional studies on the stable expression of α2A-and α2C-AR subtypes in CHO cells showed that Synephrine acts as presynaptic α(2A)-and α(2C) an antagonist rather than an agonist of the-AR subtype, although the antagonistic activity of Synephrine is less than its partial excitatory potency. Synephrine (~ 100 μm) treatment increased basal glucose consumption by 50% compared with the control group. This effect was dose-dependent and did not affect the viability of L6 skeletal muscle cells. Synephrine significantly stimulated basal and insulin-stimulated lactate production and glucose consumption. Synephrine treatment stimulated phosphorylation of AMPK but not of Akt, and Synephrine-induced glucose consumption and Glut4 translocation from the cytoplasm to the plasma membrane were sensitive to inhibition of AMPK but not to inhibition of PI3K. |
| In vivo study | Rats with Portal hypertension induced by partial portal vein ligation (PVL) or bile duct ligation (BDL) were treated with Synephrine at a dose of 1 mg/kg every 12 h for 8 days, significant improvements in hyperdynamic status, and in PVL and BDL rats, also significant reductions in partial portal pressure, departmental Portal tributary blood flow, and cardiac index. |
| Plant Source: | fructus aurantii immaturus |
| effect | synephrine can be used as a vasopressor for Shock, for heart failure, treatment of bronchial asthma and surgery and anesthesia at the end of the blood pressure, collapse and Shock, body, position hypotension, etc.; Alpha adrenergic receptor agonists, vasoconstrictors, etc. 1. Effects on cardiovascular immaturus aurantii, decoction of fructus aurantii, extract of immaturus aurantii, injection of immaturus aurantii and its active ingredients, can significantly enhance the anesthetic dog a variety of myocardial contractility and pump blood function indicators, with strong heart, contraction of blood vessels, improve the total peripheral resistance, and the left ventricular pressure and arterial blood pressure rise. Modern research has also confirmed that fructus aurantii immaturus can increase the tension of rabbit aorta in a concentration-dependent manner and make the smooth muscle of aorta contract. 2. Effect on weight loss as a weight loss promoting agent, synephrine hydrochloride has an action mechanism of stimulating β-3 adrenoceptor to cause lipid decomposition and subsequent thermogenesis. Most of the dietary supplements containing synephrine hydrochloride also contain different other ingredients, mainly caffeine, salicylic acid and ephedrine. The combination of the various chemical components described above can enhance the efficacy of synephrine hydrochloride for weight loss. Taking rats as the research object, repeated oral administration of commercially available lime water-alcohol extract with standardized content of synephrine hydrochloride was conducted to evaluate its food intake and cardiovascular function, and it was found that lime extract could reduce food intake and weight gain, the electrocardiogram of the animals in the experimental group was abnormal. |
| side effects | severe hypertension, tachyarrhythmia, patients with narrow-angle glaucoma and recipients of monoamine oxidase inhibitors should avoid taking fructus aurantii immaturus extract. Synephrine hydrochloride can cause a cyclic deviation of Head Pain and primary Head Pain. Literature studies have shown that dietary supplements containing synephrine hydrochloride also contain other such as methyl xanthine, ephedrine, taurine. Methylxanthine toxicity is manifested in the cause of tremor, tachycardia, seizures. Ephedrine, which has a stimulating effect on the central nervous system, can cause side effects such as heart failure and stroke. The presence of such substances will increase the side effects of the product and pose a health threat. |
| biological activity | Synephrine HCl is a sympathetic alpha-adreneric receptor (AR)(adrenoceptor) agonist. |
| Target | Value |
| Use | for content determination/identification/pharmacological experiments |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.