Hebei Nengqian Chemical Import and Export Co., LTD
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Business Type:Trading Company
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Tel: 86-139-10575315
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Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
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Ms.AnnaCAS NO.60-33-3
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
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Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
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(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Introduction | α-linoleic acid is colorless to pale yellow oily liquid at room temperature, and is easy to oxidize in air. Melting point (°c): -12, boiling point (°c): 230(2.13kPa). Linoleic acid is the body can not be synthesized, or the amount of synthesis can not meet the needs of fatty acids, called essential fatty acids. Linoleic acid and alpha-linolenic acid are clearly defined nutrition essential fatty acids. They are of great significance to human health. But this is not to say that the complement of linoleic acid, increase the intake of linoleic acid, will have a positive effect on human health. On the contrary, when the intake ratio of linoleic acid and alpha-linolenic acid is much higher than 4:1, it will not bring us health, but will make us produce high blood lipids, high blood viscosity and other diseases derived therefrom (such as: Myocardial infarction |
| Use | α-linoleic acid is useful as a nutritional supplement, as a drying oil in paints and varnishes, and also in the manufacture of pharmaceuticals. nutritional supplement, flavoring agent. hypolipidemic drug for the treatment and prevention of atherosclerosis. Generally no side effects. Long-term use can appear Nausea, Vomit, Diarrhea and other gastrointestinal reactions, continue to administration can gradually disappear. linoleic acid is an essential fatty acid in human and animal nutrition. Animals and plants have desaturase, can make saturated fatty acid dehydrogenation, produce oleic acid class of unsaturated fatty acids with a double bond, but only plant cells have the ability to further dehydrogenation of oleic acid into linoleic acid. Linoleic acid is a precursor for the synthesis of animal prostaglandins. Lack of linoleic acid, linolenic acid and other fatty acids, will make the animal dysplasia, skin and kidney damage, infertility and so on. Linoleic acid can be combined with cholesterol into Ester, and can promote the degradation of cholesterol into bile acid, and then excreted in vitro, also reduce the role of triglycerides. In medicine for the prevention and treatment of atherosclerosis drugs (such as yishuning, Mai Tong, etc.) raw materials. In industry, linoleic acid used in paint, ink production and preparation of amide, polyester, polyurea. The sodium or potassium salt of linoleate is one of the components of soap and can be used as a surfactant such as an emulsifier. Linoleic acid is non-toxic. In the human body, metabolites are important nutritional elements of the brain, and have a good role in the prevention and treatment of cardiovascular and cerebrovascular diseases. Biochemical Study |
| range of use | according to national standards, the recommended dosage is 1‰ to 3. |
| Overview | linoleic acid, a fatty acid. The molecular formula CH3(CH2)4CH = CHCH2CH = CH(CH2)7COOH. His name is cis -9,12-octadecadienoic acid. Linoleic acid, together with other fatty acids, is present in animal and vegetable fats and oils in the form of glycerides, and is a main component of drying oils and semi-drying oils such as linseed oil and cottonseed oil, which are formed in the form of glycerides. |
| toxicity | GRAS(FDA § 182.5065;§ 184.1065;2000). |
| usage limit | GMP(FDA § 182.5065,2000). |
| method of production | linoleic acid is present in animal fat in the form of glycerides together with other fatty acids. The content of animal fat is generally low, such as butter 1.8%, lard for 6%; Several kinds of vegetable oil content is higher, such as peanut oil for 26%, rapeseed oil for 15.8%, the fatty acids in soybean are mainly linoleic acid. Soybean oil fatty acids are generally composed as follows: oleic acid 15-33% linoleic acid 53-56% linolenic acid 5-9% palmitic acid 7-11% stearic acid 2-6%C20 above acid 0.3-3% soybean oil in the refining process about 5-10% oil and soap foot. Half of the soybean oil soap stock is a useful fatty acid, and the fatty acids in the soap stock are essentially identical to the fatty acid composition of soybean oil. Therefore, the extraction of linoleic acid from soybean oil is an important way for the comprehensive utilization of soybean oil. method 1. Preparation of crude linoleic acid with corn oil as raw material the amount of clear corn oil is taken, 200g/L sodium hydroxide solution is gradually added, stirring is added, and stirring is continued for 15min after adding, the mixture was placed at 25-40 ℃ for 48h for saponification. The saponified material was removed, milled into fragments with a wood spatula, slowly added with 45%-50% sulfuric acid, and acidified at 30-40 ℃ for 7H to obtain crude linoleic acid. Corn germ oil [NaOH, 25-40 ℃]→ saponified product [H2SO4, 30-40 ℃]→ preparation of crude linoleic acid linoleic acid product crude product was placed in a separatory funnel, and 2 times the volume of 30 ℃ tap water was added, shaking, removing the water layer, repeating this for 5-6 times, then washing with warm distilled water until sulfate-free, to obtain linoleic acid solution. Add 100g/L anhydrous sodium sulfate, shake, at 25-30 ℃, stand for 48-96H to obtain refined product. The refined product is suction filtered, and the filtrate is the finished linoleic acid. Linoleic acid crude product [H2O, 30 ℃]→ linoleic acid solution [anhydrous Na2SO4, 25 ℃]→ linoleic acid refined product [suction filter] → linoleic acid finished product method 2, preparation of soap pulp with soybean oil foot as raw material soybean oil foot was taken, heated to about 90 ℃, a small amount of 1/10-1/7 times of sodium hydroxide solution was added, and heating was continued for 15min, the remaining alkali solution was added to the phenolphthalein indicator, and then heated and boiled for 2-3H to obtain a saponified product. Add 1/20-1/10 times the amount of industrial sodium chloride into the saponified material twice, and heat until the soap slurry does not stick to the knife when the knife is sampled. When there is obvious black water precipitation, heat it for 1-2H, keep still for 3H, draw out the lower layer of black water, soap slurry. Refined oil lower foot [NaOH, >90 ℃]→ saponification liquid [NaCl]→ preparation of soap pulp black fatty acid the waste acid water extracted from the first batch of acidification is added to the soap pulp, and the steam is heated for 30min, let stand for 1H, draw out the waste water, slowly add 1/10-1/7 times the amount of concentrated sulfuric acid until stratification occurs, let stand for 1H, draw out the lower waste acid water, and reserve it for the next batch of acidification, acidification fluid was obtained. Add 3 times the amount of water in the acidification liquid, steam heating to 80 ℃ above 20min, standing for 30min, pumping waste water, repeat the operation for 3-4 times, until the wastewater pH value is 6-7, black acid is obtained. Soap slurry [H2SO4]→ acidizing solution [H2O, >80 ℃]→ preparation of crude oleic acid linoleic acid black fatty acid was heated to about 105 ℃, fed into a distillation column in batches and distilled under reduced pressure, the temperature of the biphenyl furnace is 270-290 ℃, the pressure is 49-117.68kPa, the vacuum degree of the distillation column is above 99.75kPa, and the gas phase temperature is 190-200 ℃. 1.5h each time, steamed out of mixed fatty acids, and put black feet 1 times. Freeze the mixed fatty acid to about 0-2 ℃, take it out and load it into a wet bag, press it with an oil press, gradually increase the pressure to 14.71MPa, press it for 10-12H, and the extract is crude linoleic acid, the solid left in the bag was stearic acid. Preparation of linoleic acid product the crude linoleic acid was heated to 100 ℃ and sucked into the distillation tower, feeding 90kg each time, biphenyl furnace temperature 265-275 ℃, pressure 19.6-49kPa, distillation tower vacuum degree above 99.75kPa, gas phase temperature 185-200 ℃, the distillate was linoleic acid. Linoleic acid crude product [185-200 ℃,100kpa]→ linoleic acid finished product. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.