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Hebei Nengqian Chemical Import and Export Co., LTD

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Hebei Nengqian Chemical Import and Export Co., LTD

Country: China (Mainland)

Business Type:Trading Company

Mr.cui

Tel: 86-139-10575315

Mr.Jacky

Tel: +86 15632961819

Ms.Winnie

Tel: +86 18233902561

Ms.Mandy

Tel: +86 15717685612

Ms.Chris

Tel: +86 16630923639

Ms.Sunny

Tel: +86 18732968538

Ms.Bailey

Tel: +86 18833033983

Ms.Anna

Tel: +86 19831957301

Mobile: +86 19831957301

Tel: 86-139-10575315

Fax: 4001020630

URL: https://www.nengqianchemical.com/

Province/state: Hebei

City: Handan

Street: Congtai District, La Defense North

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Phenylephrine hydrochloride

CAS NO.61-76-7

  • FOB Price: USD: 1,630.00-1,800.00 /Metric Ton Get Latest Price
  • Min.Order: 1 Metric Ton
  • Payment Terms: L/C,D/A,D/P,T/T,Other
  • Available Specifications:

    Industrial Grade(1-10)Metric TonIndustrial Grade(10-101)Metric TonIndustrial Grade(100-300)Metric Ton

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Product Details

Keywords

  • L(-)-Phenylephrine hydrochloride
  • L(-)-PHENYLEPHRINE HCL
  • (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride

Quick Details

  • ProName: Phenylephrine hydrochloride 61-76-7
  • CasNo: 61-76-7
  • Molecular Formula: C9H14ClNO2
  • Appearance: White Crystalline Powder
  • Application: It is used for surgical surgery to pro...
  • DeliveryTime: 7-15 working days
  • PackAge: Bag/compartments
  • Port: tianjin
  • ProductionCapacity: 200 Metric Ton/Month
  • Purity: 99%
  • Storage: Dry, away from light, sealed.
  • Transportation: We will choose the mode of transportat...
  • LimitNum: 1 Metric Ton
  • color: White powder

Superiority

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.

Consistent Quality
Our plant has strict quality control in each manufacturing process. Guaranteed.
Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.

Most competitive pricing
Our company is committed to the production and development of titanium dioxide, we always offer the most competitive pricing to customers to help lower their cost in application.

Shortest delivery time
90% of orders are shipped within 7-10 days after receipt of the prepayment or workable L/C.

Respond in 24 hours to inquiry, feedback or other requirements
Our experienced staff is dedicated to answer all of your inquires, feedback or other requirements in 24 hours.

We welcome you to contact us for more information and look forward to working with yo

Details

Product introduction:

Melting Point 143-145°C(lit.)
Specific Rotation(α) -47 º (c=2, H2O)
Flash Point 9℃
Water Solubility >=10 g/100 mL at 21 ºC
Solubility Freely soluble in water and in ethanol (96 per cent).
Appearance White crystal
Color White to almost white
Merck 14,7286
BRN 4158948
pKa pK1 8.77; pK2 9.84(at 25℃)
PH pH (10g/L, 25℃) : 4.5~5.5
Storage Condition 2-8°C
Stability Hygroscopic
Refractive Index -45.5 ° (C=1, H2O)
MDL MFCD00012605
Physical and Chemical Properties White or off-white crystalline powder. Melting point 140-145 °c. Soluble in water, ethanol, insoluble in chloroform, ether. The melting point of the L-free base is 169-172 °c.
Use Adrenaline-like drugs. It has a contractile effect on local body blood vessels. It is used for surgical surgery to prolong the anesthesia time of local treatment and reduce swelling and inflammation of nasal mucosal congestion.
In vitro study Phenylephrine caused a rapid translocation of PKC-epsilon(EC 50=0.9mm), but the proportion of loss from the soluble fraction was less than ET-1. Phenylephrine caused a dose-dependent increase in the contractile force of hyperpermeable cells at pCa 7, which was reversible upon addition of phentolamine. Phenylephrine also protects cardiomyocytes from hypoxia and serum-deprivation treatment. Phenylephrine prevents down-regulation of Bcl-2 and Bcl-X mRNA/proteins and induction of hypertrophic growth. Phenylephrine-mediated protection is inhibited by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptide inhibitor LEHD-FMK. Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes associated with cardiac hypertrophy [e. G., atrial natriuretic factor (ANF)]. Phenylephrine(1 μm) significantly enhanced HGF-induced hepatocyte DNA synthesis and cell proliferation. Phenylephrine(1 mM) reversibly increased I(Ca,L)(51.3%; N = 40) and the peak I(Ca,L) of the activation voltage at -10 mV. Phenylephrine also increases the release of sarcolemmal SR calcium ions via ip3-dependent signaling. Phenylephrin induces the release of NOi, requiring stimulation by PI-3K/Akt and ip3-dependent calcium ion signals. Phenylephrine induces the release of NOi as 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C inhibition.

Phcnylephrine Hydrochloride Injection

Authoritative Data Verified Data

This product is a sterile aqueous solution of phenylephrine hydrochloride. Containing phenylephrine HCL (C9H13N02 • HC1) shall be between 95.0% and 105.0% of the label amount.

trait

This product is a clear colorless liquid.

identification

  1. taking this product, according to the identification (1) Test under the item of hydrochloric acid and phenylephrine, the same reaction was shown.
  2. a test solution under the item of related substances was taken, an appropriate amount of phenylephrine hydrochloride control was taken, and methanol was added to prepare a solution containing about 20mg per 1 ml as a control solution. Test according to the method under the item of related substances, from the "Thin layer chromatography (General 0502) test", the same method operation. The position and color of the main spot displayed by the test solution should be consistent with the main spot of the control solution.
  3. This product is chloride identification reaction (General 0301).

examination

  • the pH value should be 3.0 to 5.0 (General 0631).
  • the related substances were protected from light. Take this product, dry it on a water bath, and add methanol to make a solution containing about 20mg of phenylephrine hydrochloride per 1 ml, as a test solution; Take appropriate amount with precision, dilute with methanol to make a solution containing about 0502 mg per 1 ml, as a control solution. According to thin layer chromatography (general) test, draw on each of the above two solutions, on the same silica gel G thin layer plate, respectively, with isopropyl alcohol-three gas methane-concentrated ammonia solution (80:5:15) as the developing solvent, expand, dry, spray with diazobenzene sulfonic acid solution to make color development. Test solution such as impurity spots, compared with the control solution of the main spot, the color should not be darker (1.0%).
  • bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg of phenylephrine hydrochloride containing endotoxin should be less than 25EU. For intrathecal injection should be less than 4.0EU.
  • others should comply with the relevant provisions under injection (General 0102).

Content determination

take 5ml of this product accurately, put it in an iodine bottle, add lml of dilute hydrochloric acid, carefully boil it to near dryness, let it cool, add 20ml of water, and add 0.05mol/L of bromine titration solution accurately. 25ml, and then 2ml hydrochloric acid, immediately tamponade, shake, place for 15 minutes and always shake, pay attention to micro-open the stopper, add potassium iodide solution 7ml, immediately tamponade, shake after, with sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of bromine titrant (0.05mol/L) corresponds to 3.395mg of C9H13N02. HCI.

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

 

 

 

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within3-5 working days after full payment.

transport

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.