Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.62-31-7
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Density | 1.4 g/cm3 |
| Melting Point | 248-250°C(lit.) |
| Boling Point | 337.7 °C at 760 mmHg |
| Flash Point | 11℃ |
| Water Solubility | soluble |
| Solubility | Soluble in water, soluble in methanol and hot 95% ethanol, soluble in sodium hydroxide solution, insoluble in ether, chloroform and benzene. |
| Appearance | White-like crystal |
| Color | light tan |
| Merck | 14,8462 |
| BRN | 3656720 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Sensitive | Air & Light Sensitive |
| MDL | MFCD00012898 |
| Physical and Chemical Properties |
Melting Point: 241 - 243
|
| Use | Dopamine agonist, excites the heart, increases renal blood flow, for hemorrhagic, cardiac and Infective Shock |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | UX1092000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29222900 |
| Hazard Note | Irritant |
| Toxicity | LD50 orally in Rabbit: 2859 mg/kg |
| Introduction | the neurotransmitter dopamine is widely distributed in the mammalian central nervous system, brain tissue and body fluids, its trace determination is of great significance in neurophysiology, exercise physiology, pathology, clinical medicine and disease diagnosis. Dopamine (DA) is one of the most important catecholamines, which plays a key role in the central nervous system and renal system. Disorders such as heart disease, schizophrenia, and Parkinson's disease can result from an imbalance in dopamine production. Dopamine Hydrochloride water soluble, can enhance myocardial contractility, increase blood output, and a large number of used in myocardial infarction, trauma, endotoxin sepsis, cardiac surgery, renal failure, congestive heart failure caused by Shock syndrome. |
| Application | dopamine hydrochloride can be used for various types of Shock, hypotension. Including toxic Shock, cardiac Shock, hemorrhagic Shock, central Shock, especially for patients with renal insufficiency, decreased cardiac output, increased peripheral vascular resistance and has made up the blood volume. Also can treat cardiac insufficiency, acute renal insufficiency. |
| pharmacological effects | This product is a precursor for the synthesis of epinephrine in vivo, with beta (mainly beta 1 receptor) receptor agonist effect, it also has an alpha receptor agonistic effect and can also promote the release of norepinephrine. It can enhance myocardial contractility, increase cardiac output, and accelerate heart rate slightly (not as obvious as isoproterenol). It excites alpha receptors of blood vessels in tissues such as skin and muscle, and reduces blood flow supply; exciting visceral blood vessels (kidney, mesentery, heart) of dopamine receptors, then make the expansion, increase blood flow. The change of total peripheral resistance was not obvious, but it was beneficial to improve the blood supply of important organs by Shock. |
| effect | dopamine is a precursor of norepinephrine biosynthesis, one of the central transmitters, with the ability of stimulating β-receptor, action of a-receptors and dopamine receptors, exciting the heart beta-receptors can increase myocardial contractility, increase cardiac output. Stimulating dopamine receptors and α-receptors dilates the kidney, mesentery, coronary artery and cerebral vessels, and increases blood flow. It has mild contractile effect on peripheral blood vessels and increases arterial blood pressure. The prominent effect of this drug is to increase renal blood flow and glomerular filtration rate, thus promoting the increase of urine volume and urinary sodium excretion. Clinical for various types of Shock, especially for Shock with reduced cardiac contractility, renal insufficiency. |
| adverse reactions | the common ones are chest pain, Dyspnea, palpitations, arrhythmia (especially in large doses), rapid and potent heart beat, weakness and weakness of the whole body; Slow heartbeat, vomiting in Head Pain and Nausea were rare. Long-term use of large or small doses in patients with peripheral vascular disease, the reaction of hand foot pain or cold hands and feet; Peripheral vascular contraction for a long period of time, may lead to local necrosis or gangrene. |
| purpose | This product is a vasopressor and a Biochemical reagent. Dopamine receptor agonist, can stimulate the heart, increase renal blood flow, for hemorrhagic, cardiac and Infective Shock. Neurotransmitter |
| production method | is obtained by ring-opening piperonyl ethylamine. Piperonyl ethylamine and phenol were added to the reaction Pan, cooled, hydrochloric acid was slowly added, and the temperature was raised to 110 ° C. And refluxed for 12-44H. After the reaction reached the end point, it was slightly cooled, and water was added and stirred evenly. The patient was allowed to stand in layers, and phenol layer was removed. The aqueous layer was extracted with isopropyl acetate, and the extracted aqueous layer was evaporated to dryness under reduced pressure (8.0kPa). Then, a 1/2 amount of ethanol and hydrochloric acid were added and dissolved by heating. The product was obtained by cooling, crystallization, filtration, washing of the filter cake with ethanol, and drying. The yield was 74%. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50 2859 mg/kg; Oral-mouse LD50: 4361 mg/kg |
| flammability hazard characteristics | flammable, combustion decomposition of toxic nitrogen oxides, chloride gas |
| storage and transportation characteristics | warehouse low temperature, ventilation, dry |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.