Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.625-33-2
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
| Molar Mass | 84.12 |
| Density | 0.862 g/mL at 25 °C (lit.) |
| Melting Point | <2% ethanol |
| Boling Point | 121-124 °C (lit.) |
| Flash Point | 70°F |
| JECFA Number | 1124 |
| Water Solubility | Slightly soluble in Water |
| Vapor Presure | 760 mm Hg ( 121 °C) |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 1633505 |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Stable. Flammable. Incompatible with strong oxidizing and strong reducing agents, strong acids, strong bases. |
| production method | 1. Found in Cranberry, bilberry, fried peanut, potato chips. It is prepared by condensation and dehydration of acetone and acetaldehyde under basic conditions, or reaction of propylene with acetyl chloride in the presence of aluminum trichloride. 2. Note that this reaction must be performed in a fume hood. The 2-liter three-necked flask was fitted with an effective mechanical stirrer, a gas input tube (extending almost to the bottom of the bottle), and a highly efficient reflux condenser with a calcium chloride drying tube. After the apparatus was allowed to dry in an oven, 800 of dry methylene chloride and 157g (142, 2.0 mol) of ethyl phthalate chloride were placed in the bottle. The solution was stirred and 320g of 2.4} mol) powdery anhydrous aluminum trichloride was added in portions over a period of minutes. Once the addition is complete, a stream of propylene is passed through the continuously stirred reaction solution at a rate sufficient to maintain gentle reflux. Gas addition was continued until no further heat evolution and reflux was stopped (10-30 hours). At this point the inside of the bottle is nearly full, and when stirring is stopped, the contents are separated into two layers. The contents of the bottle were carefully poured onto 1.5 of ice. The upper organic layer was separated. The aqueous layer was extracted with 3 parts} 0} ml of dichloromethane. The organic solutions were combined, washed with 50 ml of water and dried over anhydrous magnesium sulfate. The resulting dark brown solution was placed in a national bottom flask equipped with a thermometer, a magnetic stirrer, and a reduced-pressure tin evaporation apparatus, and heated with a heating mantle. While maintaining the mixture at 0 °c, the mixture was distilled under reduced pressure using a water pump. Most of the distilled out of the mixture is dichloromethane and volatile hydrocarbons. After most of the solvent has been distilled off, a 1 liter round bottom flask cooled in a dry ice-isopropanol bath is attached to the tin evaporation unit as a receiver, the pressure was reduced to lmm. The viscous liquid in the steamed radium bottle was slowly heated from 0 °c to 45 °c in 90 minutes using a heating mantle. At this time, the volatile products (containing dichloromethane, low molecular weight hydrocarbons, 4 chloro pentane -2 ketone and 3 pentene 2 ketone) were distilled out. Between 400 and 500g of a pale green distillate are obtained, mixed with 256G (1i mol) of the bite phase, and then heated to boiling. In order to remove residual methylene chloride and other low-boiling substances, the mixture is distilled radium until the temperature of the distillate rises to 110-120 °c. The remaining solution is refluxed for 30 minutes and then cooled, the mixture was diluted with previously distilled distillate and 200 ml of pentane, and the resulting solution was washed with several portions of 250 ml of 10% aqueous hydrochloric acid until the aqueous wash became acidic. The aqueous solutions were combined and acidified. Shake with 3 parts of 100mm pentane. The organic solutions were combined, washed with 50 ml of saturated sodium bicarbonate solution and then dried over anhydrous magnesium sulfate. The obtained organic solution was subjected to a 30cm long pine needle-shaped fractionation column, and a 119-124 ° C. Fraction was collected. The rent product weighed 42-63G (25-37%). The purity was 86-92%. If a higher purity product is desired, a 60cm spinneret column may be used for distillation. Due to distillation may be accompanied by a, beta unsaturated ketone partial isomerization into a lower boiling point of the ISO Beta, Gamma isomer, Fractionation of the resulting product should be subject to acid catalytic equilibrium treatment. A typical method of purification is to mix 79.4G of a mixture of pentene -2-one isomers having a boiling point of 117 to 119 from the fractional distillation with 400 mg of p-toluenesulfonic acid and reflux for 30 minutes. The resulting mixture was diluted with 100 ml of ether, then washed with 50 ml of saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate. 3. Tobacco: FC,40. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.