Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.751-03-1
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Molecular Formula | C26H30O7 |
| Molar Mass | 454.51 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 229～230℃ |
| Boling Point | 626.2±55.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)-50 |
| Flash Point | 361.2°C |
| Solubility | Insoluble in water, soluble in chloroform, acetone, glacial acetic acid, insoluble in ether, slightly soluble in ethanol. |
| Vapor Presure | 4.54E-19mmHg at 25°C |
| Appearance | Colorless crystal |
| Storage Condition | 2-8°C |
| Refractive Index | 1.614 |
| MDL | MFCD00075888 |
| Physical and Chemical Properties | Soluble in ethyl acetate, acetone, DMSO and other solvents, insoluble in water. From Phellodendron chinense, a plant of Rutaceae |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | RR1104200 |
| HS Code | 29322090 |
| Reference
Show more |
1. Zhou Lili, Zuo, Ling, Ma Donglei. Determination and cluster analysis of the content of the content of the white fresh... |
| plant origin | 1. Main source-cortex phellodendri: The original name of Aralia was published in Shen Nong's natural classic of grass, which is listed as top grade. "Chinese Pharmacopoeia" 1963 edition of a collection in Phellodendron. Due to the yellow bark, it is named Phellodendron amurense. Alias guanbai, Aralia, Phellodendron amurense, bark, Sabina vaginalis. cortex phellodendri is the dried bark of the yellow-bark tree, phellodendronchinen schneid. Or Phellodendron phellodronamurenserupr. The former is called "Phellodendron chinense", and the latter is called "Phellodendron chinense". cortex phellodendri is mainly produced in Sichuan, Guizhou and other provinces, Shaanxi, Hubei, Yunnan, Hunan, Gansu, Guangxi and other provinces. Phellodendron amurense is mainly produced in Jilin, Liaoning and other provinces. Inner Mongolia, Hebei, Heilongjiang and other provinces also produced. Remove the coarse skin to yellow, and dry to semi-dry in the sun, overlap into a stack, flatten with a stone plate, and then dry in the sun. Quality specifications to dry, bright yellow, thick skin to clean, skin thickness is better. Figure 2 is the original plant and medicinal materials of cortex phellodendri The main chemical components of cortex phellodendri are: Alkaloids-Berberine (Berber), magnolin (Magnoflorine), Phellodendrine (Phellodendrine) jatrorrhizine, palmar Tetrandrine (Palmatine), etc.; Esters-Phellodendron lactone (Obaculactone), Phellodendron ketone (Obacunone), White fresh lactide (Dictamnolide); Organic acids; Sterols. chemical characterization of Phellodendron chinense: Take 1g of this product powder, Add 10ml of ether, shake and filter, volatilize the filtrate to dryness, add 1mL of glacial acetic acid to dissolve the residue, and add 1 drop of hydrochloric acid, the solution was purple-brown. (Check for flavanone and sterols). 2. Other sources: cortex phellodendrine phellodendri phellodendri cortex phellodendri. Stem bark P.molleNakai stem bark pomelo citrusgranis (L.) osbeck seed C.medicaL. Fruit Coptis chinensis Coptis chinensis (Coptis chinensis) Franch. HarrisoniaabyssinicaOliver, a plant of the bitter Wood family. |
| separation and extraction | the optimum extraction process of Phellodendron amurense ketone from White fresh skin was as follows: Extracting twice with 8 times the amount of 95% ethanol, 1h every time. According to the optimized extraction process, the extraction rate was 4.192mg/g. |
| determination of content | high performance liquid chromatography, column Agilent C18(150nm × 4.6nm,5 μm), the mobile phase was Methanol-Water (60: 40); The flow rate was 0.8ml/min; The column temperature was 25 ℃; The detection wavelength was 212nm. The range of content of Phellodendron amurense in different areas was 2.41-3.01mg/g. Figure 3 is the liquid chromatogram of White fresh skin sample White fresh skin has a wide range of applications in traditional Chinese medicine, in 2010, the Pharmacopoeia of the People's Republic of China added the reference substance for the determination of the content of the chemical constituents of the white fresh bark, and the Pharmacopoeia of the People's Republic of China added the item of [content determination] under the item of "white fresh bark, provisions of the white fresh skin medicinal materials" this product according to the calculation of the dry product, containing not less than 0.15%. there are some differences in the content of Phellodendron amurense in different habitats. The results of content determination and cluster analysis showed that the content of Phellodendron amurense in Inner Mongolia was the highest and was divided into one group separately, anhui was divided in a group; Liaoning, Heilongjiang, Jilin were divided in a group; Shaanxi, Shandong, the lowest, were divided in another group. |
| pharmacological action | 1. Efficacy of cortex phellodendri: cortex phellodendri is bitter and cold. It belongs to kidney, bladder and large intestine. Fire detoxification strong, good governance of damp heat diarrhea, sore, jaundice, bring down, hot shower, beriberi, etc. Spleen and stomach deficiency cold should not be used. 2. Modern pharmacological research 1. Cause the insect to produce the antifeeding behavior 2. Microtubule inhibition potentiation: enhances the cytotoxicity of antineoplastic agents (e. G., vincristine, vinblastine, and paclitaxel) that have a microtubule-inhibiting effect, which itself has no cytotoxicity. However, there is no obvious synergistic effect on other antitumor drugs such as RNA synthesis inhibitors, alkylating agent factors, thymidylate synthase inhibitors and the like. 3. Neuroprotective activity: methanol extract of White fresh root bark has neuroprotective effect. The ethanol extracts, including the one, exhibited strong neuroprotective activity (against glutamate-induced neurotoxicity) against primary cultured rat cortical cells at a concentration of 0.1 μmol/L. 4. Limonin analogs have antitumor, insect Antifeedant, antiviral, analgesic, anti-inflammatory, hypnotic and other biological activities. |
| Microbial transformation | Microbial transformation refers to the use of enzymes produced in the process of microbial metabolism to catalyze a substrate for a chemical reaction. Microbial transformation has been applied to the synthesis of a variety of drugs. In recent years, Microbial transformation of natural products has become an auxiliary means of structural modification, and it is also a method of obtaining new compounds to screen bioactive compounds. In this paper, the transformation experiment of Chrysotile was carried out by Aspergillus Niger and other fungi. The results showed that when the culture temperature was lower than 30 ℃, the Phyllanthus emblica could catalyze the transformation of the structure of phellodendrone, and the C- 11th position was hydroxylated. The fermentation broth containing the conversion product was extracted with ethyl acetate, the compound was separated by silica gel column chromatography to obtain zapoterin. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: with fever, dysentery, and can enhance the cytotoxic effect of antitumor drugs. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.