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CAS NO.77591-33-4
medical grade(1-50)Kilogrammedical grade(50-500)Kilogram
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.
Consistent Quality
Our plant has strict quality control in each manufacturing process. Guaranteed.
Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.
Most competitive pricing
Our company is committed to the production and development of titanium dioxide, we always offer the most competitive pricing to customers to help lower their cost in application.
Shortest delivery time
90% of orders are shipped within 7-10 days after receipt of the prepayment or workable L/C.
Respond in 24 hours to inquiry, feedback or other requirements
Our experienced staff is dedicated to answer all of your inquires, feedback or other requirements in 24 hours.
We welcome you to contact us for more information and look forward to working with yoWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements.
Consistent Quality
Our plant has strict quality control in each manufacturing process. Guaranteed.
Meanwhile all the materials are tested before each shipment in our laboratory to double confirm the quality.
Most competitive pricing
Our company is committed to the production and development of titanium dioxide, we always offer the most competitive pricing to customers to help lower their cost in application.
Shortest delivery time
90% of orders are shipped within 7-10 days after receipt of the prepayment or workable L/C.
Respond in 24 hours to inquiry, feedback or other requirements
Our experienced staff is dedicated to answer all of your inquires, feedback or other requirements in 24 hours.
We welcome you to contact us for more information and look forward to working with you
Name | Thymosin beta 4 acetate |
Synonyms | Fx Peptide Thymosin β4 Thymosin beta4 Thymosin Beta 4 Thymosin beta(4) Thymosin β4 Acetate THYMOSIN SS4 ACETATE Thymosin beta 4 acetate thymosin beta 4 acetate Thymosin Beta4 Beta4 Acetate FX (HUMAN, BOVINE, HORSE, RAT) THYMOSIN BETA4 (HUMAN, BOVINE, HORSE, RAT) AC-SER-ASP-LYS-PRO-ASP-MET-ALA-GLU-ILE-GLU-LYS-PHE-ASP-LYS-SER-LYS-LEU-LYS-LYS-THR-GLU-THR-GLN-GLU-LYS-ASN-PRO-LEU-PRO-SER-LYS-GLU-THR-ILE-GLU-GLN-GLU-LYS-GLN-ALA-GLY-GLU-SER-OH |
CAS | 77591-33-4 |
EINECS | 1592732-453-0 |
InChI | InChI=1/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20,42-43,104-112,115-149,166-170,269-275H,16-17,21-41,44-103,213-221H2,1-15H3,(H2,222,277)(H2,223,278)(H2,224,279)(H2,225,280)(H,226,304)(H,227,306)(H,228,307)(H,229,276)(H,230,281)(H,231,305)(H,232,318)(H,233,320)(H,234,319)(H,235,308)(H,236,326)(H,237,328)(H,238,333)(H,239,332)(H,240,309)(H,241,321)(H,242,316)(H,243,317)(H,244,310)(H,245,329)(H,246,337)(H,247,338)(H,248,339)(H,249,340)(H,250,330)(H,251,311)(H,252,312)(H,253,327)(H,254,331)(H,255,334)(H,256,313)(H,257,335)(H,258,314)(H,259,336)(H,260,315)(H,261,323)(H,262,341)(H,263,322)(H,264,325)(H,265,324)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H,300,301)(H,302,303)(H,345,346) |
Molecular Formula | C212H350N56O78S |
Molar Mass | 4963.4408 |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Use | Cornea, skin repair, etc |
Open Data Verified Data
Open Data Verified Data
The fresh or frozen thymus was subjected to fat removal and crushing, and then 3 times the amount of physiological saline was added to prepare a homogenate in a tissue Shaker, followed by high-speed centrifugation to obtain an extract (component 1). The extract was heated at 80 °c for 15min to precipitate heat-labile heteroproteins. The precipitate was removed by centrifugation to obtain a supernatant (component 2). The supernatant was cooled to 4 °c and then 5 volumes of acetone at -10 °c were added and the precipitate was collected by filtration and dried to give Acetone Powder (component 3). Acetone Powder was dissolved in pH 7.O phosphate buffer solution, and ammonium sulfate was added to reach a saturation of 0. 25, the precipitate was removed by centrifugation, the supernatant (component 4) was adjusted to pH 4.0, and ammonium sulfate was added to reach a saturation of 0. 50, the salting out material. The salting-out material was dissolved in a phosphate buffer solution at pH 8, filtered, and then an ultrafiltrate having a molecular weight of 15000 or less was taken. The ultrafiltrate was desalted by Sephadex G-25 column and then freeze-dried to obtain Thymosin.
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.201 ml | 1.007 ml | 2.015 ml |
5 mM | 0.04 ml | 0.201 ml | 0.403 ml |
10 mM | 0.02 ml | 0.101 ml | 0.201 ml |
5 mM | 0.004 ml | 0.02 ml | 0.04 ml |
Open Data Verified Data
usage and dose of immune enhancer. Treatment of immunodeficiency diseases, such as thymic hypoplasia syndrome, ataxia telangiectasia. With thrombocytopenia eczema multiple infection syndrome and chronic mucocutaneous mycosis. For children with thymic hypoplasia, may be long
Thymosin (1 mg/kg body weight) was used as replacement therapy. Try in AIDS patients. For the treatment of recurrent aphthae, leprosy, severe infection and other patients with low immune function, 20-60mg bovine Thymosin intramuscular injection or subcutaneous injection every time, 1-3 times a week for several months; Porcine Thymosin, 2-lOmg daily or every other day.
Open Data Verified Data
A few people appeared urticaria, rash and other local allergic reactions, occasional dizziness Fever and other systemic allergic reactions. Skin test should be done before injection (including before re-injection after drug withdrawal).
Overview | thymic β4 is a member of the Thymosin β family. Thymic β4 is composed of 43 amino acids and is hydrophilic. |
Application prospect | The latest research shows that the expression level of β4 gene in thymus acetate is positively correlated with cancer cell metastasis, it is closely related to tumor apoptosis. This provides a new way to find a new method for the treatment of cancer, so it has a broad prospect for the development of new drugs. |
biological function and mechanism of action | Tβ4 is one of the main actin regulatory molecules in human body, which has multiple biological functions, in tissue regeneration, remodeling, wound healing, maintaining the balance of actin, tumor pathogenesis and metastasis, apoptosis, inflammation, angiogenesis, hair follicle development and other physiological, pathological process plays a very important role. 1. Actin regulatory factors actin accounts for about 10% of the total protein in non-muscle cells and is an important component of cell structure, cell movement and wound healing. Tβ4 in the cell is sufficient to block all actin and may be involved in the regulation of actin polymerization and depolymerization. Tβ4 can bind to actin monomer in a ratio of 1:1 to prevent the formation of F-actin aggregates, its C- terminus binds to actin His-40, resulting in a change in actin monomer conformation. Tβ4 molecular structure contains an actin binding domain (LKKTET), which is the main electrostatic contact site, and its N-terminal fragment can inhibit actin polymerization through steric hindrance, when acting alone, Tβ4 can inhibit actin polymerization and actin nucleoside exchange, which is contrary to the role of another actin binding protein Profiling, the latter can promote the exchange of ADP and ATP, accelerate the assembly of actin, Tβ4 and Profiling can coordinate the regulation of actin assembly. Tβ4 can regulate the transformation between G-actin and F-actin. It has been reported that in highly mobile blood cells, the concentration of Tβ4 reaches 300pmol, while the concentration required for binding of Tβ4 to G-actin is less than 20pmol; When the concentration is increased, tβ4 reduces the depolymerization ability of F-actin, which may be the reason why Tβ4 has the function of regulating the intracellular microfilament system. |
Use | thymus acetate β4 has the following uses: 1. Thymic β4 and tumor studies have shown that thymic β4 acetate is associated with a variety of tumors, including colon cancer, melanoma, fibrosarcoma, breast cancer, pancreatic cancer and lung cancer, it can cooperate with a variety of factors to promote tumor invasion and metastasis. 2. The role of thymic β4 in the repair of cardiac injury in the acute phase of myocardial infarction, a large number of myocardial cell ischemic necrosis, resulting in impaired cardiac function, and ultimately progress to heart failure. Studies have confirmed that thymic acetate β4 can protect myocardial cells. |
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages:
1, High quality with competitive price:
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product photo
Product Packaging:
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage:
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery:
Usually within3-5 working days after full payment.
transport:
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
FAQ:
1.Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3.How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5.Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6.How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9.How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.