Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 18732968538
Mobile: +86 18732968538
Tel: +86 18732968538
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.83480-29-9
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Molecular Formula | C10H21NO7 |
| Molar Mass | 267.28 |
| Density | 1.58±0.1 g/cm3(Predicted) |
| Melting Point | 162-163°C |
| Boling Point | 601.9±55.0 °C(Predicted) |
| Specific Rotation(α) | D25 +26.2° (c = 1 in water) |
| Flash Point | 274.1°C |
| Solubility | H2O : 100 mg/mL (374.14 mM; Need ultrasonic);DMSO : 100 mg/mL (374.14 mM; Need ultraso |
| Vapor Presure | 5.37E-17mmHg at 25°C |
| Appearance | White to off-white crystalline powder |
| Color | White to Off-White |
| Merck | 14,10029 |
| pKa | 13.26±0.70(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.635 |
| MDL | MFCD00865496 |
| Use | For the treatment of diabetes |
| In vitro study | Voglibose can inhibit intestinal alpha-glucosidase enzymes, which are responsible for the digestion of disaccharides such as maltose and sucrose, including maltase and sucrase. The K I value of Voglibose for sucrase and maltase is less than the K m value of sucrose and maltose about 10 |
| In vivo study | Voglibose (0.2 mg/kg) completely inhibited the insulin response to sucrose and reduced the carbohydrate-induced increase in blood glucose in mice. Voglibose (0.2 mg/kg) acts on both normal and neonatal strep tozotocin-induced diabetic rats to reduce the carbohydrate-induced increase in blood glucose without causing persistent hypoglycemia. After 3 weeks of treatment with Voglibose (0.001%) in pre-diabetic db / db mice, there was a GLP-1 increase in secretion (Voglibose alone, 1.6-fold; Alogliptin plus Voglibose,1.5-fold), while reducing plasma insulinotropic polypeptide (GIP)(Voglibose alone, 30%; Alogliptin plus voglibose, 29%). Treatment of pre-diabetic db / db mice with Voglibose (0.001%) increased plasma insulin 1.8-fold, reducing plasma DPP-4 activity by 15% and plasma glucagon by 8%. Voglibose (0.001% and 0.005%) acts on ob/ob mice to stimulate secretion in GLP-1, adding to the standard inactive amidated GLP-1, increasing plasma activity by 1.3 to 1.5 fold. Action of Voglibose (0.001% and 0.005%) on ob/ob mice unexpectedly reduced plasma DPP-4 activity by 40% to 51%, resulting from a decrease in plasma DPP-4 concentration. Voglibose (0.001% and 0.005%) acts on ob/ob mice to increase 1.5-to 1.6-fold the content of GLP-1, decreasing 1.4-to 1.6-fold in the small intestine and large intestine, respectively. |
| Oral hypoglycemic drug | Voglibose is an oral hypoglycemic drug that can improve diabetes Postprandial hyperglycemia, successfully developed by Takeda Company of Japan, belongs to α-glucosidase inhibitor (a drug that delays the absorption of carbohydrates in the intestine to achieve hypoglycemic effect ), the mechanism of action is to inhibit the disaccharide hydrolase (α-glucosidase) that breaks down disaccharides into monosaccharides in the intestine, thus delaying the digestion and absorption of sugar, thereby improving postprandial hyperglycemia. Healthy adults were given after sucrose load, the exhaled hydrogen was measured, and the results confirmed that the drug has an inhibitory effect on blood sugar increase under clinical dosage. When normal rats are given orally, this product inhibits the increase of blood sugar after loading with starch, maltose and sucrose, but has no inhibitory effect on the increase of blood sugar after loading with glucose, fructose and lactose. Studies on the mechanism of action of in vitro experiments show that this product has a strong inhibitory effect on maltase and sucrase obtained from the small intestine of pigs and rats; on the other hand, It has a weak inhibitory effect on α-pancreatic amylase in pigs and rats, but has no inhibitory effect on β-glucosidase. The disaccharide hydrolase of the sucrase-isomaltase complex of the rat small intestine is a competitive inhibition. It is understood that Voglibose has a wide range of applications, not only for middle-aged and elderly diabetic patients, but also for refractory type 2 diabetic patients, patients with secondary failure of sulfonylureas, and diabetic patients with hyperlipidemia, Diabetes patients with heart and brain blood tube disease, and patients with hyperinsulinemia have significant effects. Since this product does not stimulate the secretion of insulin, it can reduce the harmful effects of postprandial hyperinsulinemia, reduce insulin resistance, and is beneficial to the prevention and treatment of metabolic syndrome such as cardiovascular complications. |
| indications | voglibose, as a second-generation α-glycosidase inhibitor, mainly selectively inhibits sucrase and maltase, and its inhibitory activity on these two enzymes is much higher than that of acarbose. Because it does not affect amylase, the starch in food is converted into disaccharide in the small intestine, and the starch entering the large intestine is very small, so there are fewer gastrointestinal reactions such as abdominal distension and increased exhaust. Voglibose is rarely absorbed by prototype drugs, and more than 98% are metabolized in the intestine and excreted in feces, so it can be used in patients with mild to moderate liver dysfunction. Voglibose tablets are the first choice and first-line medication for diabetic patients with high blood sugar after meals. They are suitable for all age groups and can be arbitrarily matched with other non-similar hypoglycemic drugs, such as insulin, secretagogues, etc. It is more suitable for patients with difficult diet control. Single-quality sugar control. Any dose will not cause hypoglycemia due to drug factors. When combined with insulin and secretagogues, attention should be paid to the risk of hypoglycemia. It is recommended to start taking it at a small dose. |
| side effects | the mechanism of side effects of oral hypoglycemic drugs is generally that after unabsorbed sugar enters the large intestine, under the action of bacteria, it is fermented to produce carbon dioxide, hydrogen and organic acids. At the same time, due to increased intestinal osmotic pressure and water retention, there is increased exhaust, abdominal distension and diarrhea. Since voglibose can selectively inhibit disaccharide hydrolase in the intestine, delay the rapid digestion and absorption of sugars in the upper part of the small intestine, and reduce the amount of sugar entering the large intestine, the incidence of adverse reactions is low . It is known to have the following adverse reactions: 1) digestive system: diarrhea, soft stools, abdominal ringing, abdominal pain, constipation, loss of appetite, nausea, vomiting, heartburn (incidence rate below 0.1-5%), stomatitis, thirst, abnormal taste, intestinal wall cystic pneumocytosis (0.1% below ) 2) allergic symptoms: rash, pruritus, photosensitivity (incidence below 0.1%) 3) Liver: GOT, GPT, LDH, γ-GTP, ALP (incidence below 0.1%) 4) Mental nervous system: headache, dizziness, faltering, drowsiness (incidence below 0.1%) 5) Blood system: anemia (incidence rate below 0.1-5%), thrombocytopenia (below 0.1%) 6) others: paralysis, facial edema, hazy eyes, fever, tiredness, fatigue, hyperkalemia, increased serum amylase, decreased high density lipoprotein, sweating, hair removal (incidence rate below 0.1%). |
| biological activity | Voglibose (AO 128) is an N-substituted Jinglianolamine derivative, which has excellent inhibitory activity against α glucosidase, and also has anti-hyperglycemia and various diseases caused by hyperglycemia. |
| target | TargetValue α-glucosidases |
| Target | Value |
| in vitro studies | Voglibose can inhibit intestinal α-glucosidase, which is responsible for the digestion of disaccharides, such as maltose and sucrose, including maltase and sucrase. The K I values of Voglibose for sucrase and maltase are respectively less than the K m values of sucrose and maltose by about 10 |
| in vivo studies | Voglibose (0.2 mg/kg) acts on mice to completely inhibit the insulin response of sucrose and reduce the increase of carbohydrate-induced blood sugar. Voglibose (0.2 mg/kg) acts on normal and newborn streptozotocin-induced diabetic rats to reduce carbohydrate-induced increase in blood sugar without causing persistent hypoglycemia. After 3 weeks of Voglibose (0.001%) treatment of prediabetic db / db mice, it increased GLP-1 secretion (Voglibose alone, 1.6 times; Alogliptin plus Voglibose,1.5 times), while reducing plasma insulinotropic polypeptide (GIP)(Voglibose alone, 30%; Alogliptin plus voglibose, 29%). Voglibose (0.001%) treatment of prediabetic db / db mice increased plasma insulin by 1.8 times, decreased plasma DPP-4 activity by 15% and plasma glucagon by 8%. Voglibose (0.001% and 0.005%) acted on ob/ob mice to stimulate the secretion of GLP-1. When added to the standard inactive amidation GLP-1, the activity in plasma increased by 1.3 to 1.5 times. Voglibose (0.001% and 0.005%) acts on ob/ob mice to accidentally reduce the activity of plasma DPP-4 40% to 51%, which is caused by reducing the concentration of plasma DPP-4. Voglibose (0.001% and 0.005%) acted on ob/ob mice to increase the GLP-1 content by 1.5-to 1.6-fold, and decreased by 1.4 to 1.6-fold in the small intestine and large intestine respectively. |
| use | used to treat diabetes antidiabetic drugs |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.